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Cat. No.: HY-128576

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DS21360717

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

DS21360717 is a potent and orally active FER tyrosine kinase inhibitor, with an IC₅₀ of 0.49 nM. Anti-cancer activity.

For research use only. We do not sell to patients.

Purity: 99.80%
CAS No.: 2304654-43-9
Formula: C₂₁H₂₃N₇O
Molecular Weight:389.45

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

DS21360717 Chemical Structure

CAS No.: 2304654-43-9

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Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- Cellular Effect
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

DS21360717 is a potent and orally active FER tyrosine kinase inhibitor, with an IC₅₀ of 0.49 nM. Anti-cancer activity^[1].

All EGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	GI₅₀	220 nM Compound: 21; DS21360717	Growth inhibition of mouse mock transfected BA/F3 cells assessed as decrease in cell viability after 3 days by luminescence based CellTiter-Glo assay Growth inhibition of mouse mock transfected BA/F3 cells assessed as decrease in cell viability after 3 days by luminescence based CellTiter-Glo assay	[PMID: 31097992]

Chemical Information

CAS No. 2304654-43-9
Appearance Solid
Molecular Weight 389.45
Formula C₂₁H₂₃N₇O
Color White to light yellow
SMILES

N[C@H]1CCCC[C@H]1NC2=NC(NC3=CC(C)=CC=C3)=C4C(C=NNC4=O)=C2C#N
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

Nat Commun

Molecular landscape, subtypes, and therapeutic vulnerabilities of central nervous system solitary fibrous tumors. [Abstract]

2025 Aug 23;16(1):7870. PMID: 40849425
Heliyon

Decorin impeded the advancement of thyroid papillary carcinoma by thwarting the EGFR/ FER/ SHP2 signaling-induced sustenance of early endosomes. [Abstract]

2024 Jun 20;10(13):e33358. PMID: 39035505

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (513.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5677 mL

12.8386 mL

25.6772 mL

5 mM

0.5135 mL

2.5677 mL

5.1354 mL

10 mM

0.2568 mL

1.2839 mL

2.5677 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Taniguchi T, et al. Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity. ACS Med Chem Lett. 2019 Mar 15;10(5):737-742. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5677 mL	12.8386 mL	25.6772 mL	64.1931 mL
	5 mM	0.5135 mL	2.5677 mL	5.1354 mL	12.8386 mL
	10 mM	0.2568 mL	1.2839 mL	2.5677 mL	6.4193 mL
	15 mM	0.1712 mL	0.8559 mL	1.7118 mL	4.2795 mL
	20 mM	0.1284 mL	0.6419 mL	1.2839 mL	3.2097 mL
	25 mM	0.1027 mL	0.5135 mL	1.0271 mL	2.5677 mL
	30 mM	0.0856 mL	0.4280 mL	0.8559 mL	2.1398 mL
	40 mM	0.0642 mL	0.3210 mL	0.6419 mL	1.6048 mL
	50 mM	0.0514 mL	0.2568 mL	0.5135 mL	1.2839 mL
	60 mM	0.0428 mL	0.2140 mL	0.4280 mL	1.0699 mL
	80 mM	0.0321 mL	0.1605 mL	0.3210 mL	0.8024 mL
	100 mM	0.0257 mL	0.1284 mL	0.2568 mL	0.6419 mL

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100 mg

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DS21360717

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Anti-Hepatitis C Virus Compound Library

Anti-Pancreatic Cancer Compound Library

Angiogenesis-Related Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cysteine Targeted Covalent Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Publications Citing Use of MedChemExpress (MCE) DS21360717

All EGFR Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

DS21360717

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Anti-Hepatitis C Virus Compound Library

Anti-Pancreatic Cancer Compound Library

Angiogenesis-Related Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cysteine Targeted Covalent Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Publications Citing Use of MedChemExpress (MCE) DS21360717

All EGFR Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

DS21360717 Related Classifications

HY-128576 Related Classifications