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Cat. No.: HY-105193

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E 3040

E 3040 is an orally active dual inhibitor of 5-lipoxygenase and thromboxane synthase. E 3040 exhibits anti-inflammatory effect.

For research use only. We do not sell to patients.

CAS No.: 145096-30-6
Formula: C₁₆H₁₇N₃OS
Molecular Weight:299.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

E 3040 Chemical Structure

CAS No.: 145096-30-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

E 3040 is an orally active dual inhibitor of 5-lipoxygenase and thromboxane synthase. E 3040 exhibits anti-inflammatory effect^[1].

IC₅₀ & Target^[1]

5-Lipoxygenase

All Lipoxygenase Isoforms :

All Prostaglandin Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
RBL-1	IC₅₀	0.23 μM Compound: 26a	Tested for inhibitory activity against 5-lipoxygenase in microsome of RBL-1 cells Tested for inhibitory activity against 5-lipoxygenase in microsome of RBL-1 cells	[PMID: 7932529]

In Vivo

E 3040 (30-100 mg/kg, p.o.) shows anti-inflammation effect in LPS (HY-D1056)-treated rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

LPS (HY-D1056)-treated rats^[1]
Dosage:

30 and 100 mg/kg
Administration:

Orally administration
Result:

Inhibited the increase in vascular permeability.
Inhibited the production of leukotriene B(4) and thromboxane B(2).
Increased the production of prostaglandin E(2).

Chemical Information

CAS No. 145096-30-6
Molecular Weight 299.39
Formula C₁₆H₁₇N₃OS
SMILES

OC1=C(C)C(CC2=CC=CN=C2)=C3N=C(NC)SC3=C1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Oketani K, et al. Effect of E3040, an inhibitor of 5-lipoxygenase and thromboxane synthase, on rat bowel damage induced by lipopolysaccharide. Eur J Pharmacol. 2001 Sep 14;427(2):159-66. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References

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E 3040

All Lipoxygenase Isoforms

All Prostaglandin Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

E 3040 Related Classifications

HY-105193 Related Classifications