country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-P12013

Copy Link Print Information

PEG12KL4

PEG12KL4 is a PEG-modified amphipathic cell-penetrating peptide. PEG12KL4 promotes the transfection and delivery of mRNA into lung cells, maintains mRNA stability, and forms mRNA complexes that retain integrity and translatability. PEG12KL4 endows lipid nanoparticles (LNPs) with anti-nebulization properties, enhances transfection efficiency in artificial mucus when used in combination with LNPs, and enables the formation of dry powder formulations with low toxicity and mild inflammatory responses. PEG12KL4 can be used in studies related to drug delivery for pulmonary diseases (cystic fibrosis, chronic obstructive pulmonary disease).

For research use only. We do not sell to patients.

Formula: C₁₅₃H₂₉₁N₂₇O₃₅
Molecular Weight:3069.11

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PEG12KL4 Chemical Structure

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

PEG12KL4 (1.5-40 mol%; at least 30 min)-containing LNPs with 10 mol% PEG12KL4 (P10NP3) maintain stable hydrodynamic size, polydispersity index, zeta potential, and encapsulation efficiency following nebulisation^[1].
PEG12KL4-containing LNPs with 10 mol% PEG12KL4 (P10NP3) maintain consistent mRNA transfection efficiency in A549 cells following nebulisation^[1].
PEG12KL4 forms stable mRNA complexes that can be processed into dry powder aerosols via spray drying and spray freeze drying while preserving mRNA integrity and translational capability^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 3069.11
Formula C₁₅₃H₂₉₁N₂₇O₃₅
SMILES

O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)=O
Sequence

PEG12-Lys-Leu-Leu-Leu-Leu-Lys-Leu-Leu-Leu-Leu-Lys-Leu-Leu-Leu-Leu-Lys-Leu-Leu-Leu-Leu-Lys-NH2
Sequence Shortening

PEG12-KLLLLKLLLLKLLLLKLLLLK-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ma C. The combination of PEG12KL4 peptide and lipid nanoparticles (LNPs) for pulmonary mRNA delivery via nebulisation. DDL2025, 2025.

[2]. Yokoo H, et al. Cell-Penetrating Peptides: Emerging Tools for mRNA Delivery. Pharmaceutics. 2021 Dec 29;14(1):78. [Content Brief]

[3]. He X, et al. Nonviral targeted mRNA delivery: principles, progresses, and challenges. MedComm. 2025 Jan;6(1):e70035. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote