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Cat. No.: HY-149101

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Inosine-5'-diphosphate

Name: Inosine-5'-diphosphate
Brand: MedChemExpress
SKU: HY-149101
Price: 25.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: IDP; Inosine-5'-diphosphoric acid)

Inosine-5'-diphosphate (IDP) is a decoy substrate of NM23-H2. Inosine-5'-diphosphate has a superior bond capacity on GDP-binding pocket of NM23-H2 (K_D: 5.0 μM). Inosine-5'-diphosphate abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphate has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Inosine-5'-diphosphate disodium) that retains the same biological activity.

For research use only. We do not sell to patients.

CAS No.: 86-04-4
Formula: C₁₀H₁₄N₄O₁₁P₂
Molecular Weight:428.19

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

Inosine-5'-diphosphate Chemical Structure

CAS No.: 86-04-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-W013724
Inosine-5'-diphosphate disodium

NM23-H2 Decoy Substrate

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vivo

Inosine-5'-diphosphate (250 mg/kg; p.o.; single dose) increases the swimming duration of the mice, with no significant influence on the strength endurance. At the same condition, Inosine-5'-diphosphate increases the rate of survival of the experimental animals in the thermal chamber^[1].
Inosine-5'-diphosphate (50 mg/kg; p.o.; once daily for 6 days) increases the hanging duration of the mice, while has no significant effect on the duration of swimming and running^[1].
Inosine-5'-diphosphate (100 mg/kg; p.o.; 1 h befor test) has appreciable radio protective effect against γ-irradiation for mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 86-04-4
Molecular Weight 428.19
Formula C₁₀H₁₄N₄O₁₁P₂
SMILES

O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O3)C=N2)NC=N1
Synonyms

IDP; Inosine-5'-diphosphoric acid
Structure Classification
- Others
Initial Source
- Animal
Penaeus joyneri (miers)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sengupta P, et al. Inosine 5'-diphosphate, a molecular decoy rescues Nucleoside diphosphate kinase from c-MYC G-Quadruplex unfolding. Biochim Biophys Acta Gen Subj. 2020 Sep;1864(9):129649.

[2]. Sokolov I K, et al. Adaptogenic effect of riboxin[J]. Pharmaceutical Chemistry Journal, 1980, 14(1): 34-39.

[3]. Veveris M, et al. Experimental study of the antiarrhythmic effect of riboxin. Farmakol. Neirotropnykh Sredstv (1978), 119-24.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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