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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
54 Results for "
ES
" in MedChemExpress (MCE) Product Catalog:
Products (54)
54 Results for "ES" in MCE Product Catalog:
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7 Publications Verification
QX77 is a chaperone-mediated autophagy (CMA) activator and upregulates LAMP2A expression in vitro. QX77 induces Rab11 upregulation, rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells . QX77 can impede self-renewal and promote differentiation of ES cells .
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Glycine max (L.) merr Coumarins Phenols Polyphenols Leguminosae Extract Phenylpropanoids Plants Disease Research Fields Cancer
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Endosidin-2 (ES2) is a selective inhibitor targeting the conserved exosome subunit EXO70. Endosidin-2 binds to the C-terminal domain of EXO70, inhibiting exocytosis and endosomal recycling, while promoting vacuolar trafficking in plant cells. Endosidin-2 interferes with the EXO70-mediated vesicle-to-plasma membrane anchoring process, leading to abnormal aggregation of auxin transporters (such as PIN2) in the cytoplasm and redirected to vacuolar degradation, while causing abnormal Golgi structure (such as cup-shaped or ring-shaped vesicles cisternae formation). Endosidin-2 can inhibit exocytosis in plant and mammalian cells and is mainly used to study the dynamic regulation of membrane trafficking (such as polar growth, vesicle sorting) .
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1 Cited Publications
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ES 936 is a potent and specific NQO1 inhibitor. ES 936 inhibits the growth of MIA PaCa-2 and BxPC-3 cells, with IC50 values of 108 nM and 365 nM, respectively. ES936 significantly inhitbits the growth rate of MIA PaCa-2 xenograft tumors in mice. ES 936 can be used for the study of pancreatic cancer .
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1 Cited Publications
ES9-17 is an analog of ES9 (endosidin9), which is an inhibitor of clathrin heavy chain (CHC). ES9-17 is an inhibitor of clathrin-mediated endocytosis (CME), a major route for internalization of plasma membrane proteins and molecules from the extracellular environment in plants. ES9-17 inhibits the uptake of transferrin and FM4-64. ES9-17 also inhibits root growth of Arabidopsis seedings .
Synonyms: ES-285
Cat. No.: HY-P991336
CAS No.: 2708115-83-5
Synonyms: INBRX-106; ES-102
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Cat. No.: HY-160715
CAS No.: 2296821-50-4
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BNT411 is a selective TLR7 agonist that can induce the release of IFNa both in vivo and in vitro. BNT411 has anticancer activity and can be used in cancer research, including non-small cell lung cancer, pancreatic cancer, and untreated extensive-stage small cell lung cancer (ES-SCLC) .
Cat. No.: HY-P990738
CAS No.: 2539845-73-1
Synonyms: ES-101; INBRX-105
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Cat. No.: HY-159621
CAS No.: 364361-68-2
Synonyms: ES5
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Endosidine 5 (ES5) inhibits EPS (extracellular polymeric substance) secretion and cell wall expansion. Endosidine 5 alters secretion of ECM (extracellular matrix) material in Penium margaritaceum by affecting the Golgi apparatus. Endosidine 5 interferes with recycling endosomes through Annexin A6, thereby promoting the release and expression of mRNA into the cytoplasm .
Cat. No.: HY-U00112
CAS No.: 172377-52-5
Synonyms: BLE 00084; E2MATE; ES-J 995
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Estradiol 3-sulfamate (BLE 00084; E2MATE; ES-J 995) is a potent, long-acting, and orally active steroid sulfatase inhibitor; inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM.
Cat. No.: HY-164373
CAS No.: 1898232-70-6
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SC428 is an androgen receptor (AR) inhibitor that targets the N-terminal domain. SC428 potently decrease the transactivation of (AR)-V7, (AR)v567es, as well as full-length ( AR ) (AR-FL) and its LBD mutants, substantially. SC428 inhibits androgen-stimulated (AR)-FL nuclear translocation, chromatin binding, and (AR) -regulated gene transcription. SC428 inhibits the proliferation of tumor cells in vitro. SC428 inhibits tumor cell growth by inducing apoptosis in mice transplanted with 22RV1 .
Cat. No.: HY-164476
CAS No.: 2089721-94-6
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ES-072 is an orally effective selective EGFR mutant (EGFR-T790M) inhibitor. ES-072 activates GSK3α by inhibiting EGFR-T790M activity, which promotes phosphorylation of PD-L1 at Ser279 and Ser283. The phosphorylated PD-L1 recruits the E3 ubiquitin ligase ARIH1, leading to ubiquitination and proteasomal degradation of PD-L1. This mechanism not only reduces cancer cell growth but also enhances anti-tumor immune response by lowering PD-L1 levels. ES-072 can be used to inhibit proliferation in non-small cell lung cancer (NSCLC) cells .
Cat. No.: HY-137007
CAS No.: 1496553-39-9
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SMA-12b is a small molecule analogue of the parasitic worm compound ES-62. SMA-12b has immunomodulatory activity, acting by regulating the expression of multiple inflammatory response genes, especially those associated with inflammatory bodies. SMA-12b significantly reduces the expression of cytokine IL-1β associated with inflammatory bodies and inhibites the production of IL-1β through a mechanism mediated by NRF2. SMA-12b can be used in the study of rheumatoid arthritis (RA) and other autoimmune diseases .
Cat. No.: HY-125625
CAS No.: 116326-39-7
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ES 6864 is an orally active, competitive inhibitor for human renin, with an IC50 of 6.9 nM and a Ki of 7.3 nM. ES 6864 exhibits high species-specific and enzyme-specific properties. ES 6864 exhibits metabolic stability in rat tissue homogenates. ES 6864 reduces blood pressure in rats and sodium-depleted awake marmosets .
Cat. No.: HY-117913
CAS No.: 129445-88-1
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ES-8891 is a renin inhibitor. Oral administration of ES-8891 to normotensive sodium-depleted macaques for one week significantly reduced plasma renin activity, immunoreactive renin concentrations, and plasma angiotensin I concentrations, while mean blood pressure decreased significantly, without significant changes in heart rate. ES-8891 regulates blood pressure by inhibiting plasma renin levels and renal renin synthesis .
Cat. No.: HY-16906
CAS No.: 1351927-00-8
T338C Src-IN-2 is a mutant c-Src kinase inhibitor, with an IC50 of 317 nM against T338C c-Src, 57 nM against T338C/V323A c-Src, and 19 nM against T338C/V323S c-Src. T338C Src-IN-2 inhibits the kinase activity of endogenous cysteine gatekeeper MOK. T338C Src-IN-2 reduces global phosphotyrosine levels in v-Src-ES1-transformed NIH-3T3 cells .
Cat. No.: HY-P991367
Cat. No.: HY-158709
CAS No.: 1356250-80-0
Cho-es-Lys is a cationic lipid synthesized by coupling natural cholesterol and amino acids, which has high gene transfection efficiency. Cho-es-Lys can be used in drug delivery research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
