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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
123 Results for "
MBP
" in MedChemExpress (MCE) Product Catalog:
Products (123)
123 Results for "MBP" in MCE Product Catalog:
30
30 Publications Verification
Cat. No.: HY-B0713
CAS No.: 68302-57-8
Synonyms: AA673; Amoxanox; CHX3673
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Amlexanox (AA673; Amoxanox; CHX3673) is a specific inhibitor of IKKε and TBK1, and inhibits the IKKε and TBK1 activity determined by MBP phosphorylation with an IC50 of approximately 1-2 μM.
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ZYF0033 is an orally active inhibitor of the hematopoietic progenitor cell kinase HPK1 with an IC50 of less than 10 nM based on the phosphorylation inhibition of MBP protein. ZYF0033 promotes anti-cancer immune responses and reduces phosphorylation of SLP76 (serine 376). ZYF0033 inhibits tumor growth in the 4T-1 syngeneic mouse model and leads to increased intratumoral infiltration of DCs, NK cells, and CD107a +CD8 + T cells, but not T cells, PD-1 +CD8 + T cells, TIM-3 +CD8 + Infiltration of T cells and LAG3 +CD8 + T cells was reduced .
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2 Cited Publications
Cat. No.: HY-P2456
CAS No.: 138028-00-9
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PD 174265 is a highly selective, reversible EGFR/ErbB2 tyrosine kinase inhibitor (IC50=0.45 nM) and cell differentiation inducer. By blocking receptor autophosphorylation and the downstream ERK signaling pathway (with an IC50 of 0.45 μM for full-length ERK), PD 174265 effectively inhibits tumor growth and exhibits antitumor activity without obvious toxicity in in vivo models. PD 174265 drives oligodendrocyte precursor cells to switch from a proliferative state to a differentiated state, significantly upregulates the expression of myelin proteins such as CNP, PLP and MBP, and induces neurite branching. PD 174265 shows no inhibitory effect on other kinases including insulin, PDGF and basic FGF receptors, and serves as a crucial tool molecule for investigating the treatment of human epidermoid carcinoma and the mechanism of myelin repair in multiple sclerosis .
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NCGC00249987 is a highly selective and allosteric Tyr phosphatase activity of Eya2 inhibitor with IC50s of 3 μM and 6.9 μM for Eya2 ED and MBP-Eya2 FL. NCGC00249987 specifically targets migration, invadopodia formation, and invasion of lung cancer cells .
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3-Bromocarbazole is an inhibitor of the aryl hydrocarbon receptor (AHR). 3-Bromocarbazole induces the mRNA expression of CYP1A1 and CYP1B1, with EC50 values of 2500 nM and 1100 nM, respectively. 3-Bromocarbazole inhibits motor neuron axon length by downregulating the mRNA transcription levels of α1-tubulin, Gap43, Syn2a and shha in zebrafish larvae. 3-Bromocarbazole reduces central nervous system neurogenesis by downregulating the mRNA transcription levels of elavl3, nrd, mbp and gfap in zebrafish larvae. 3-Bromocarbazole induces developmental neurotoxicity and decreases body length in zebrafish larvae or embryos; at high concentrations, it also reduces hatching rate, and increases mortality and malformation rate. 3-Bromocarbazole can be used in studies related to developmental neurotoxicity and breast cancer .
Cat. No.: HY-P10532
CAS No.: 121196-80-3
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Synonyms: Calcium D-glucarate tetrahydrate
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Cat. No.: HY-P3723
CAS No.: 178823-45-5
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Cat. No.: HY-P1048
CAS No.: 98474-59-0
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Cat. No.: HY-P3073
CAS No.: 106128-98-7
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Cat. No.: HY-P3724
CAS No.: 604803-17-0
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Cat. No.: HY-P3940
CAS No.: 138250-62-1
Cat. No.: HY-W130541
CAS No.: 118-82-1
Synonyms: 4,4-MBP
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4,4'-Methylenebis(2,6-di-tert-butylphenol) (4,4-MBP) is a bisphenol compound. 4,4'-Methylenebis(2,6-di-tert-butylphenol) acts as an inhibitor of sarco/endoplasmic reticulum calcium ATPase (SERCA) with an IC50 value of 17 μM. 4,4'-Methylenebis(2,6-di-tert-butylphenol) can be used in the research of diseases related to calcium homeostasis .
Cat. No.: HY-P991450
Synonyms: ADI-15742; MBP-134 AF
Cat. No.: HY-P3739
CAS No.: 136132-68-8
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Cat. No.: HY-P1996
CAS No.: 178823-49-9
Synonyms: NBI-5788
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Cat. No.: HY-P3248
CAS No.: 444305-16-2
Synonyms: Myelin basic protein (85-99) antagonist
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Cat. No.: HY-P10428
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
