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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
225 Results for "
beta-lactam
" in MedChemExpress (MCE) Product Catalog:
Products (225)
225 Results for "beta-lactam" in MCE Product Catalog:
Cat. No.: HY-L914
3,211 compounds
In the research of covalent inhibitors targeting serine and threonine, scientists have found that the nucleophilicity of these hydroxyl groups is significantly enhanced due to the influence of their surrounding environment. This results in higher activity during catalytic reactions. Aspirin, which targets the non-catalytic domain serine (Ser529 in human COX1) of cyclooxygenase, exerts its anti-inflammatory effect through covalent binding. β-lactam antibiotics, which targets the catalytic domain serine of penicillin-binding proteins, interferes with bacterial cell wall synthesis.
Through careful selection, we constructed a structural filter containing over 110 electrophilic groups. By analyzing the electrophilic fragments selected by the structural filter, we removed any molecules with trivial or undesirable structural features. Ultimately, we obtained 3,300 fragment molecules which can target serine and threonine residues and can be used for fragment-based covalent drug discovery.
Cat. No.: HY-P0267A
CAS No.: 1036322-26-5
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Cat. No.: HY-P3100
CAS No.: 939960-34-6
Cat. No.: HY-P1193
CAS No.: 129623-01-4
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Cat. No.: HY-P1208A
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Cat. No.: HY-P2123A
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Cat. No.: HY-P5189A
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Cat. No.: HY-P1208
CAS No.: 667430-81-1
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Cat. No.: HY-P1209
CAS No.: 944111-22-2
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Cat. No.: HY-P1209A
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Cat. No.: HY-P2123S
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Cat. No.: HY-P5568
CAS No.: 152835-17-1
Synonyms: RP 71955
Cat. No.: HY-P11596
CAS No.: 3107808-75-0
Cat. No.: HY-P2202
CAS No.: 140198-04-5
Cat. No.: HY-P11232
CAS No.: 1969250-99-4
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Cat. No.: HY-P11290
CAS No.: 1228015-10-8
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Cat. No.: HY-P11607
Cat. No.: HY-P11676
CAS No.: 1814918-91-6
Synonyms: BRII-693; QPX9003
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Cat. No.: HY-P2120
CAS No.: 79438-64-5
Cat. No.: HY-145632
CAS No.: 2538014-94-5
Synonyms: ALT-801
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
