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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3466 Results for "
Prothrombin complex concentrate
" in MedChemExpress (MCE) Product Catalog:
Products (3466)
3466 Results for "Prothrombin complex concentrate" in MCE Product Catalog:
Cat. No.: HY-W611371
CAS No.: 61694-81-3
Target:
Research Areas:
FP802 is an orally active potent TwinF interface inhibitor that disrupts and detoxifies the NMDAR/TRPM4 death complex. FP802 exerts powerful neuroprotective effects in the 5xFAD mouse model of Alzheimer’s disease (AD) by preventing cognitive decline, preserving neuronal structural integrity, reducing amyloid-β plaque formation, and mitigating mitochondrial pathology . FP802 stops loss of motor neurons, reduces serum neurofilament light chain (NfL) levels, improves motor performance, and extends life in a mouse model of amyotrophic lateral sclerosis (ALS). FP802 can be used for AD and ALS research .
Cat. No.: HY-147099
Purity: 97.8%
dTAG-47-NEG is an inactive bifunctional negative control PROTAC and also the diastereomer of dTAGV-1 (HY-145514D). dTAG-47-NEG does not reduce the level of BCL11A-FKBP12 F36V, nor does it induce the degradation of BCL11A-FKBP12 F36V, proteins tagged with FKBP12 F36V, wild-type FKBP12, FKBP12 F36V-KRAS G12V or FKBP12 F36V-EWS/FLI. dTAG-47-NEG exerts no antiproliferative effect in cancer cells .
Cat. No.: HY-156084
CAS No.: 2809353-52-2
LL-K9-3 is a selective CDK9-cyclin T1 HyT degrader, with DC50 values of 0.662 μM and 0.589 μM for CDK9 and Cyclin T1, respectively. LL-K9-3 lacks an E3 ligand moiety and induces polyubiquitination and proteasome-mediated synchronous degradation of CDK9 and cyclin T1 via a hydrophobic tag-mediated mechanism. LL-K9-3 downregulates the protein levels of androgen receptor (AR) and c-Myc, and exhibits antiproliferative and pro-apoptotic (apoptosis) activity in prostate cancer cells. LL-K9-3 can be used in studies related to prostate cancer .
Cat. No.: HY-161162
CAS No.: 2387510-81-6
Synonyms: CFT-2139
Target:
Research Areas:
aTAG 2139 (CFT-2139) is a bifunctional tag-targeted PROTAC-class degrader that induces the degradation of the MTH1 aTAG fusion protein by recruiting cereblon, with a DC50 of 1.1 nM (in Jurkat T cells). aTAG 2139 is applicable to the research of CD19-positive cancers .
Cat. No.: HY-174920
CAS No.: 1797406-70-2
Target:
Research Areas:
PROTAC BRD4 Degrader-34 (1797406-70-2) is a VHL-recruiting PROTAC BRD4 degrader. PROTAC BRD4 Degrader-34 induces degradation of the short isoform of BRD4 and can be used in studies of BRD4-related diseases and targeted protein degradation .
Cat. No.: HY-181305
CAS No.: 2653338-60-2
Target:
Research Areas:
PROTAC EZH2 Degrader-10 is a selective PROTAC protein degrader targeting EZH2. PROTAC EZH2 Degrader-10 can be used for the research of cancer .
Cat. No.: HY-181606
Research Areas:
Cyclo (phg-isoDGR-k)-PEG4-non-cleavable-SAR405838 is a dual MDM2 and α5β1 integrin modulator. Cyclo (phg-isoDGR-k)-PEG4-non-cleavable-SAR405838 acts as an antiproliferative agent, apoptosis inducer and cell cycle regulator, induces reactivation of p53 and upregulation of p21, redistributes glioblastoma cells from the G0/G1 phase to the G2/M phase, and enhances apoptosis. Cyclo (phg-isoDGR-k)-PEG4-non-cleavable-SAR405838 is applicable to the research of glioblastoma .
Cat. No.: HY-183854
CAS No.: 223784-75-6
AG-12286 is a pan-CDK inhibitor with an IC50 value of 2 nM against cdk1/cyclin B, 6 nM against cdk2/cyclin E, and 12 nM against cdk4/cyclin D. AG-12286 is 1000-fold more selective for the CDK family than for PKC. AG-12286 can be used in cancer research .
Cat. No.: HY-N11913
CAS No.: 53377-54-1
Target:
Cat. No.: HY-P1958
CAS No.: 667899-73-2
Target:
Research Areas:
Cat. No.: HY-W509797
CAS No.: 21618-92-8
Target:
Drug Metabolite TNF Receptor IKK NF-κB Autophagy NOD-like Receptor (NLR) NADPH Oxidase Keap1-Nrf2
Research Areas:
5-(3',4'-Dihydroxyphenyl)-γ-valerolactone is an intestinal microbiota metabolite of (-)-Epicatechin (HY-N0001). 5-(3',4'-Dihydroxyphenyl)-γ-valerolactone downregulates TNF-α-stimulated phosphorylation of IKK and IκBα, inhibits the transcriptional activation of NF-κB, and suppresses the expression of adhesion molecules and chemokines. 5-(3',4'-Dihydroxyphenyl)-γ-valerolactone promotes autophagy, alleviates oxidative stress, maintains osteoblast differentiation, induces G1 phase arrest, inhibits adipogenesis, and scavenges ABTS free radicals. 5-(3',4'-Dihydroxyphenyl)-γ-valerolactone inhibits the adhesion of uropathogenic Escherichia coli to bladder epithelial cells; when used in combination with Curcumin (HY-N0005), it downregulates the NLRP3 and NOX2/Nrf2 signaling pathways, thereby reducing microglial activation. 5-(3',4'-Dihydroxyphenyl)-γ-valerolactone can be used in research related to diabetes, atherosclerosis, osteoporosis, obesity, neurodegenerative diseases involving microglial activation, and urinary tract infections .
Cat. No.: HY-P70656
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FCGRT; Major Histocompatibility complex Class I-Like Fc Receptor; Fc Gamma Receptor And Transporter; Neonatal Crystallizable Fc Receptor FcRn Splice Variant 6; Neonatal Fc Receptor; Neonatal Crystallizable Fc Receptor FcRn Splice Variant 5; FcRn; Neonatal
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P72710
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD74; Ia-Associated Invariant Chain; Prev. DHLAG; HLA-DR-Gamma; CLIP; Ia Antigen-Associated Invariant Chain; CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility complex, Class II Antigen-Associated); CD74 Antigen; CD74 Molecule, Major Histocom
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P73522
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FCGRT; Major Histocompatibility complex Class I-Like Fc Receptor; Fc Gamma Receptor And Transporter; Neonatal Crystallizable Fc Receptor FcRn Splice Variant 6; Neonatal Fc Receptor; Neonatal Crystallizable Fc Receptor FcRn Splice Variant 5; FcRn; Neonatal
Species:
Human
Source:
HEK293
Cat. No.: HY-P74841
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NFKBIA; MAD-3; Prev. NFKBI; Major Histocompatibility complex Enhancer-Binding Protein MAD3; NF-Kappa-B Inhibitor Alpha; IkB-Alpha; IkappaBalpha; Nuclear Factor Of Kappa Light Chain Gene Enhancer In B-Cells; IKBA; EDAID2; I-Kappa-B-Alpha; MAD3; NFKB Inhibi
Species:
Human
Source:
E. coli
Cat. No.: HY-P75989
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PSMB6; Macropain Delta Chain; Proteasome 20S Subunit Beta 6; Proteasome Subunit Y; DELTA; Beta-1; Y; LMPY; Proteasome (Prosome, Macropain) Subunit, Beta Type, 6; PSY Large Multifunctional Protease Y; Multicatalytic Endopeptidase complex Delta Chain; Prote
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P76920
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FCGRT; Major Histocompatibility complex Class I-Like Fc Receptor; Fc Gamma Receptor And Transporter; Neonatal Crystallizable Fc Receptor FcRn Splice Variant 6; Neonatal Fc Receptor; Neonatal Crystallizable Fc Receptor FcRn Splice Variant 5; FcRn; Neonatal
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P78262
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CD74; Ia-Associated Invariant Chain; Prev. DHLAG; HLA-DR-Gamma; CLIP; Ia Antigen-Associated Invariant Chain; CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility complex, Class II Antigen-Associated); CD74 Antigen; CD74 Molecule, Major Histocom
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P75760A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FCGRT; Major Histocompatibility complex Class I-Like Fc Receptor; Fc Gamma Receptor And Transporter; Neonatal Crystallizable Fc Receptor FcRn Splice Variant 6; Neonatal Fc Receptor; Neonatal Crystallizable Fc Receptor FcRn Splice Variant 5; FcRn; Neonatal
Species:
Rat
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
