55 Results for "

FMK

" in MedChemExpress (MCE) Product Catalog:
Products (55)

55 Results for "FMK" in MCE Product Catalog:

Cat. No.: HY-P1007
CAS No.: 210344-96-0
Synonyms: Z-VE(OMe)ID(OMe)-FMK
Target:  

Caspase Apoptosis

Research Areas:  

Cancer

Z-VEID-FMK (Z-VE(OMe)ID(OMe)-FMK) is a selective and irreversible caspase-6 peptide inhibitor. Z-VEID-FMK alleviates the drug-induced augmentation of caspase-6 activity, DNA fragmentation, and cell apoptosis .
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Cat. No.: HY-141867
CAS No.: 105608-85-3
Purity:  98.71%
Synonyms: Z-Phe-Phe-FMK
Z-FF-FMK (Z-Phe-Phe-FMK) is a cell-permeable, irreversible, and cysteine protease inhibitor targeting cathepsin-L. Z-FF-FMK inhibits angiotensin II-induced MEK activation in vascular walls, aortic medial remodeling, blood pressure elevation, and upregulation of cystatin C in aortic walls. Z-FF-FMK prevents β-amyloid-mediated caspase-3 activation, poly (ADP-ribose) polymerase cleavage, DNA fragmentation, and apoptosis of cortical neurons (apoptosis). Z-FF-FMK can be used in research related to hypertension and Alzheimer's disease .
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Cat. No.: HY-P10244F
Target:  

Inhibitory Antibodies

Research Areas:  

Infection

Biotin-YVAD-FMK is an inhibitor for vacuolar processing enzyme (VPE), with a 64% inhibition at 5 μM. Biotin-YVAD-FMK is an irreversible substrate for caspase 1 .
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Cat. No.: HY-136750
CAS No.: 133410-84-1
Purity:  98.65%
Synonyms: Calpain Inhibitor IV
Research Areas:  

Cancer

Z-LLY-FMK (Calpain Inhibitor IV) is a calpain inhibitor, involved in apoptosis of many cell systems. Z-LLY-FMK inhibits the intestine apoptosis after common bile duct ligation. Z-LLY-FMK reduces parasite burden in mice challenged with Taenia crassiceps cysts. Z-LLY-FMK can be used for the study of cysticercosis .
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Cat. No.: HY-125305
CAS No.: 1135688-47-9
Purity:  ≥95.0%
Target:  

Caspase Apoptosis

Research Areas:  

Cancer

Z-AEVD-FMK is a caspase-10 inhibitor. Z-AEVD-FMK can inhibit the activation of Bid and the release of apoptosis-inducing factor (AIF) in mitochondria in cells, resulting in a significant decrease in the number of apoptotic cells .
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Cat. No.: HY-P5975
CAS No.: 371167-61-2
Synonyms: Z-LLL-FMK
Target:  

Cathepsin SARS-CoV

Research Areas:  

Infection

Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge .
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Cat. No.: HY-52101C
CAS No.: 1414811-15-6
Research Areas:  

Cancer

FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor.
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Cat. No.: HY-D1432
FITC-C6-DEVD-FMK, a fluorescently labeled caspase-3 inhibitor, can be used for detection of active caspase-3 in mammalian cells undergoing apoptosis. FITC-C6-DEVD-FMK provides a convenient means for sensitive detection of activated caspase-3 in living cells. Z-DEVD-FMK is a specific caspase-3 inhibitor .
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Cat. No.: HY-138203
CAS No.: 210344-93-7
Target:  

Caspase Apoptosis

Research Areas:  

Cancer

Z-LE(OMe)TD(OMe)-FMK is a selective caspase-8 inhibitor. Z-LE(OMe)TD(OMe)-FMK can inhibit cell apoptosis .
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Cat. No.: HY-P1010A
CAS No.: 524746-03-0
Target:  

Caspase Apoptosis

Research Areas:  

Neurological Disease Cancer

Z-LEHD-FMK TFA is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK TFA exhibits the neuroprotective effect in a rat model of spinal cord trauma .
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Cat. No.: HY-153613
CAS No.: 2679825-26-2
Purity:  ≥98.0%
Synonyms: Ac-Pro-Leu-Val-Glu(OMe)-CH2F
Target:  

Cathepsin

Research Areas:  

Cancer

Ac-PLVE-FMK (Ac-Pro-Leu-Val-Glu(OMe)-CH2F), a tetrapeptidyl m-FMKs, is a Cats inhibitor. Ac-PLVE-FMK can be used for the research of cancer .
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Cat. No.: HY-P1008A
CAS No.: 1926163-61-2
Synonyms: Z-VD(OMe)VAD(OMe)-(DL-Asp)-FMK
Target:  

Caspase

Research Areas:  

Cancer

Z-VDVA-(DL-Asp)-FMK is a Z-VDVAD-FMK derivative. Z-VDVAD-FMK (HY-P1008) is a special inhibitor of caspase-2 .
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Cat. No.: HY-16658C
CAS No.: 220644-02-0
Synonyms: Z-VA-DL-D(OH)-FMK
Target:  

Caspase

Research Areas:  

Infection

Z-VA-DL-D-FMK (Z-VA-DL-D(OH)-FMK) is an inhibitor for caspase . Z-VA-DL-D-FMK binds irreversibly to caspases, increases the sensitivity of TNF-α, and activates HIV replication in infected T cell ACH-2 .
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Cat. No.: HY-P10326
CAS No.: 1416658-51-9
Target:  

Caspase Apoptosis

Research Areas:  

Cancer

Z-ATAD-FMK is an inhibitor of caspase-12. Z-ATAD-FMK is an inhibitor of caspase-12. Z-ATAD-FMK prevents endoplasmic reticulum stress-mediated apoptosis by inhibiting the activity of caspase-12 and reducing the activity of caspase-9 .
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Cat. No.: HY-123185
CAS No.: 96922-64-4
Research Areas:  

Infection

(Rac)-Z-FA-FMK is the racemate of Z-FA-FMK. (Rac)-Z-FA-FMK is an inhibitor of cathepsin B with a Ki of 1.5 μM. (Rac)-Z-FA-FMK inhibits caspase-2, -3, -6, -7, and -9 with IC50s of 6.147, 15.41, 32.45, 9.077, and 110.7 μM. (Rac)-Z-FA-FMK inhibits the main protease of SARS-CoV-2 replication with an IC50 of 11.39 μM. (Rac)-Z-FA-FMK inhibits the increased IL-1β level induced by LPS and NF-κB transactivation in macrophages .
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Cat. No.: HY-P5122
CAS No.: 1135688-38-8
Target:  

Caspase

Research Areas:  

Inflammation/Immunology

Z-LEED-FMK is a caspase-13 and caspase-4 inhibitor. Z-LEED-FMK also inhibits caspase-1 processing in S. typhimurium-infected macrophages .
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Cat. No.: HY-16658BG
CAS No.: 161401-82-7
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .
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Cat. No.: HY-P5989
CAS No.: 912476-54-1
Synonyms: Mu-Val-HPh-FMK
Target:  

Antibiotic

Research Areas:  

Infection

Calpain inhibitor V (Mu-Val-HPh-FMK) is a cell-permeable and irreversible inhibitor of calpain that has anti-chlamydial activity .
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Cat. No.: HY-P10244
CAS No.: 350021-87-3
Target:  

Caspase

Research Areas:  

Others

Ac-YVAD-FMK is an inhibitor for caspase 1-like protease .
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Cat. No.: HY-P0110
CAS No.: 634911-81-2
Synonyms: (Iso)-Z-Val-Ala-Asp(OMe)-FMK
Target:  

Caspase

Research Areas:  

Cancer

(Iso)-Z-VAD(OMe)-FMK ((Iso)-Z-Val-Ala-Asp(OMe)-FMK) is an isomer of the caspase and UCHL1 inhibitor Z-VAD(OMe)-FMK (HY-16658) .
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