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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
257 Results for "
HO-1
" in MedChemExpress (MCE) Product Catalog:
Products (257)
257 Results for "HO-1" in MCE Product Catalog:
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4
Category:
Monophenols Simple Phenylpropanols Phenols Dicerothamnus rhinocerotis Phenylpropanoids Plants Umbelliferae
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Category:
Cardiovascular Disease Flavonols other families Flavonoids Phenols Polyphenols Plants Disease Research Fields
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3 Cited Publications
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AM-1638 is an orally active full agonist of GPR40 (EC50: 0.16 μM). AM-1638 increases the expression of antioxidant molecules (HO-1 and NQO-1). AM1638 blocks Palmitate (HY-N0830)-mediated superoxide production and ER stress. AM-1638 has antidiabetic activity and improves glycemic control in BDF mice with diet-induced obesity (DIO). AM-1638 demonstrates excellent oral bioavailability (mouse, >100%; rat, 72%; and cyno, 71%) [1] .
3
3 Cited Publications
Synonyms: Oxyberberin; Berlambine; 8-Oxoberberine
Category:
Infection Alkaloids Phellodendron amurense Rupr. Rutaceae Plants Disease Research Fields Isoquinoline Alkaloids
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3
3
3 Cited Publications
Synonyms: Creatine pHOsphate; CreatinepHOspHOric acid
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3
3 Cited Publications
Cat. No.: HY-D0885D
CAS No.: 19333-65-4
3
3 Cited Publications
Cat. No.: HY-N0651
CAS No.: 72063-39-9
Category:
Flavonoids Flavones Phenols Polyphenols Plants Actaea dahurica Turcz. ex Fisch. & C. A. Mey. Rhamnaceae
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3
3 Cited Publications
Cat. No.: HY-N0385
CAS No.: 66280-25-9
Category:
Cardiovascular Disease Monophenols Lignans Phenols Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill.
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2
2 Cited Publications
Cat. No.: HY-N0576
CAS No.: 13190-97-1
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2
2 Cited Publications
Cat. No.: HY-B2184
CAS No.: 64506-49-6
Research Areas:
Sofalcone, a gastric antiulcer agent, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
2
2 Cited Publications
Cat. No.: HY-N1970
CAS No.: 31721-94-5
Category:
other families Flavonoids Phenols Polyphenols Plants Isoflavones
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2
2 Cited Publications
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OB-24 is a selective small-molecule HO-1 inhibitor (IC50 = 1.9 μM for HO-1 and IC50 for HO-2 >100 μM). OB-24 possesses anti-tumor and anti-metastatic properties. OB-24 can be studies in research such as prostate cancer, melanoma, ovarian carcinoma and lung metastasis [1] .
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2 Cited Publications
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DI-1859 is a DCN1 and cullin 3 inhibitor with a Ki of <1 nM against human DCN1. DI-1859 forms a covalent bond with Cys115 of DCN1, cleaves its dimethylamino group, disrupts the DCN1-UBC12 interaction, and selectively inhibits the neddylation modification of cullin 3 relative to other cullins. DI-1859 inactivates CRL3, promotes the accumulation of NRF2 and SLC7A11, upregulates the expression of HO-1 and NQO1, reduces reactive oxygen species (ROS) levels, enhances insulin signaling, promotes insulin secretion, activates RhoA, regulates the phosphorylation of AKT, without completely blocking the neddylation modification of cullin 3 or restoring the expression of IRS-1. DI-1859 can be used in the research of Acetaminophen (HY-66005)-induced hepatotoxicity, hyperglycemia, metabolic dysfunction-associated steatotic liver disease, insulin resistance, breast cancer and lung cancer [1] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
