549-21-3
549-21-3
Chemical Structure
Oxyberberine
Synonym(s): Oxyberberin; Berlambine; 8-Oxoberberine
- CAS No.: 549-21-3
- Formula:C20H17NO5
- Molecular Weight:351.35
IUPAC Name: 9,10-dimethoxy-5,6-dihydro-8H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-8-one
InChIKey: ZHYQCBCBTQWPLC-UHFFFAOYSA-N
SMILES: O=C(C1=C(OC)C(OC)=CC=C1C=C23)N2CCC(C3=C4)=CC5=C4OCO5
Biological Activity: Oxyberberine (Oxyberberin; Berlambine) is an orally effective heme oxygenase HO-1 agonist that can activate antioxidant mechanisms by regulating the PI3K/Akt/AMPK signaling pathway. Oxyberberine induces HO-1 expression, increases SOD and GSH-Px activity, inhibits NF-κB-mediated inflammatory responses, and improves insulin sensitivity and glucose metabolism. Oxyberberine has anti-diabetic, neuroprotective, anti-inflammatory and antioxidant effects, and can be used to study type 2 diabetes, traumatic brain injury (TBI) and inflammatory bowel disease[1][2][3].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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Oxyberberine | 99.37% | Oxyberberine (Oxyberberin; Berlambine) is an orally effective heme oxygenase HO-1 agonist that can activate antioxidant mechanisms by regulating the PI3K/Akt/AMPK signaling pathway. Oxyberberine induces HO-1 expression, increases SOD and GSH-Px activity, inhibits NF-κB-mediated inflammatory responses, and improves insulin sensitivity and glucose metabolism. Oxyberberine has anti-diabetic, neuroprotective, anti-inflammatory and antioxidant effects, and can be used to study type 2 diabetes, traumatic brain injury (TBI) and inflammatory bowel disease. | ||||||||||||||||||||
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KRN5 | 98.58% | KRN5, a derivative of KRN2, is an oral active Nuclear factor of activated T cells 5 (NFAT5) suppressor, with an IC50 of 750 nM. KRN5 has potential to treat NFAT5-mediated Chronic Arthritis. | ||||||||||||||||||||
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13-Methylberberine chloride | 99.16% | 13-Methylberberine chloride (13-Methylberberinium chloride), a berberine analogue, has anti-adipogenic and antitumor activities. 13-Methylberberine chloride (13-Methylberberinium chloride) increases production of IL-12 and inhibits the expression of iNOS at posttranscriptional level in macrophages activated with LPS. | ||||||||||||||||||||
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Berberine chloride hydrate | 99.69% | Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties. | ||||||||||||||||||||
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Berberine chloride (Standard) | 99.78% | Berberine (chloride) (Standard) is the analytical standard of Berberine (chloride). This product is intended for research and analytical applications. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties. | ||||||||||||||||||||
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Berberine | Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties. The sulfate form (HY-N0716B) improves bioavailability. | |||||||||||||||||||||
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Berberine sulfate | 99.23% | Berberine sulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine sulfate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine sulfate has antineoplastic properties. The sulfate form improves bioavailability. | ||||||||||||||||||||
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8-Oxoepiberberine (Standard) | ≥98% | 8-Oxoepiberberine (Standard) is the analytical standard of 8-Oxoepiberberine (HY-N4173). This product is intended for research and analytical applications. 8-Oxoepiberberine is an alkaloid metabolite in serum after oral administration of Zuojin formula. Zuojin formula is a traditional Chinese medicine used for the study of gastrointestinal diseases and consists of Coptis chinensis and Evodia rutaecarpa. 8-Oxoepiberberine is predicted to be a potential active alkaloid of Heiguteng Zhuifeng Huoluo Capsule. 8-Oxoepiberberine can be used in studies related to rheumatoid arthritis. | ||||||||||||||||||||
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8-Keto-berberine | 8-Keto-berberine (compound 29) is a non-naturally occurring 11, 12-oxygenated protoberberine derived from naturally occurring 9, 10-oxygenated protoberberine. | |||||||||||||||||||||
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Oxypalmatine | 99.73% | Oxypalmatine is isolated from Phellodendron amurense. | ||||||||||||||||||||
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8-Oxocoptisine | 99.73% | 8-Oxocoptisine is a natural protoberberine alkaloid with anti-cancer activity. | ||||||||||||||||||||
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References
- [1]. Dou Y, et al. In vitro and in vivo hypoglycemia effect of oxyberberine, a novel HO-1 agonist: A renewed evidence linking HO-1 to diabetes mellitus. Phytomedicine. 2022 Jul;101:154135. [Content Brief]
- [2]. Li C, et al. Oxyberberine ameliorates TNBS-induced colitis in rats through suppressing inflammation and oxidative stress via Keap1/Nrf2/NF-κB signaling pathways. Phytomedicine. 2023 Jul 25;116:154899. [Content Brief]
- [3]. Tentu PM, et al. Oxyberberine an oxoderivative of berberine confers neuroprotective effects in controlled-cortical impact mouse model of traumatic brain injury. Int J Neurosci. 2025 Jan;135(1):80-95. [Content Brief]
