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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
38 Results for "
MALT1
" in MedChemExpress (MCE) Product Catalog:
Products (38)
38 Results for "MALT1" in MCE Product Catalog:
Cat. No.: HY-143423
CAS No.: 2434602-73-8
MALT1-IN-5 (compound 1) is a potent MALT1 protease inhibitor. MALT1-IN-5 can be used for cancer research [1].
Cat. No.: HY-143425
CAS No.: 2178993-11-6
MALT1-IN-7 (compound 142b) is a potent MALT1 protease inhibitor. MALT1-IN-7 has the potential for cancer research [1].
Cat. No.: HY-143423A
CAS No.: 2434602-25-0
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(S)-MALT1-IN-5 is a potent inhibitor of MALT1 protease. (S)-MALT1-IN-5 inhibits the activity of MALT1 is expected to be able to correct the enhancement of MALT1 activity due to abnormality of T cell receptor signal or B cell receptor signal, and cancer or inflammatory disease caused by MALT1 activity is expected. (S)-MALT1-IN-5 has the potential for the research of MALT1-related diseases (extracted from patent WO2020111087A1, compound 1) [1].
Cat. No.: HY-143424
CAS No.: 2254669-07-1
MALT1-IN-6 is a potent MALT1 protease inhibitor with a Ki of 9 nM. MALT1-IN-6 has anticancer effects (WO2018226150A1; Compound 4) [1].
Cat. No.: HY-150232
CAS No.: 2812352-99-9
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MALT1-IN-11 (Example 151 in reference Patent) is a MALT1 protease inhibitor (IC50 < 10 nM). MALT1-IN-11 inhibits IL10 secretion with an IC50 of 10-100 nM. MALT1-IN-11 can be used for the research of cancer, autoimmune and inflammatory disorders [1].
Cat. No.: HY-162268
CAS No.: 3032823-58-5
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MALT1-IN-13 (compound 10m) is inhibitor for mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), which to binds MALT1 protease covalently and irreversibly, inhibits MALT1 with the IC50 of 1.7 μM. MALT1-IN-13 inhibits proliferation against ABC-DLBCL and induces apoptosis in ABC-DLBCL HBL1. MALT1-IN-13 regulates mTOR and PI3K-Akt pathways [1].
Cat. No.: HY-143426
CAS No.: 2244109-29-1
MALT1-IN-8 is a potent MALT1 protease inhibitor with a IC50 of 2 nM. MALT1-IN-8 inhibits the growth of OCI-LY3 lymphoma cells with an IC50 of 1.16 μM. MALT1-IN-8 has anticancer effects (WO2018165385A1; Compound 8) [1].
Cat. No.: HY-164560
CAS No.: 3047242-55-4
MALT1-IN-14 (comp 2) is a MALT1 inhibitor, with an IC50 of 0.081 μM [1].
Cat. No.: HY-143425A
CAS No.: 2178993-10-5
(R)-MALT1-IN-7 (compound 142a) is a potent MALT1 protease inhibitor. (R)-MALT1-IN-7 has the potential for cancer research [1].
Cat. No.: HY-143422
CAS No.: 2504229-63-2
MALT1-IN-3 (compound 122) is a potent MALT1 protease inhibitor, with an IC50 of 0.06 μM. MALT1-IN-3 has IC50 of 0.14 and 0.13 μM for human IL6/IL10 in OCI-LY3 cells, respectively [1].
Cat. No.: HY-143422A
CAS No.: 2504229-61-0
(R)-MALT1-IN-3 (compound 121) is a potent MALT1 protease inhibitor with an IC50 of 20 nM. (R)-MALT1-IN-3 has IC50 of 60 nM, 40 nM for human IL6/IL10 in OCI-LY3 cells, respectively [1].
MLT-231 is a potent, highly selective allosteric MALT1 Inhibitor with an IC50 of 9 nM. MLT-231 specifically prevents endogenous BCL10 cleavage with IC50 of 160 nM. MLT-231 shows antitumor activity in an ABC-DLBCL type xenograft model in mouse [1].
Cat. No.: HY-186187
CAS No.: 3047242-56-5
MALT1-IN-15 is a MALT1 inhibitor with an IC50 of 0.014 μM. MALT1-IN-15 inhibits MALT1-mediated cleavage in MALT1 GloSensor reporter cells. MALT1-IN-15 inhibits the secretion of IL-6 and IL-10 in lymphoma cells. MALT1-IN-15 can be used for research on MALT1-related diseases [1].
Cat. No.: HY-P4544
CAS No.: 1926163-57-6
Cat. No.: HY-142648A
CAS No.: 1832577-07-7
(R)-MLT-985 is the R configuration of MLT-985 (HY-142648). MLT-985 is a selective allosteric and orally active MALT1 inhibitor with an IC50 value of 3 nM. MLT-985 can suppress cell growth and aberrant CARD11/BCL10/MALT1 complex signaling. MLT-985 can be used for the research of cancer, such as B cell malignancies [1] .
Cat. No.: HY-P11427
CAS No.: 259176-74-4
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
