639 Results for "

R2

" in MedChemExpress (MCE) Product Catalog:
Products (639)

639 Results for "R2" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-P1349A
Synonyms: Rat orexin B TFA; Orexin B (mouse) TFA
Orexin B, rat, mouse (Rat orexin B) TFA is an endogenous orexin receptor agonist. Orexin B, rat, mouse TFA binds and activates two closely related orphan G protein-coupled receptors OX1-R and OX2-R. Orexin B, rat, mouse TFA stimulates food intake and energy expenditure and plays a significant role in sleep-wakefulness regulation [2] .
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1 Cited Publications
Cat. No.: HY-N0909
CAS No.: 80418-25-3
Synonyms: 20(S)-Notoginsenoside R2; Ginsenoside Ng-R2
Notoginsenoside R2 (20(S)-Notoginsenoside R2; Ginsenoside Ng-R2) is an orally active notoginsenoside . Notoginsenoside R2 activates P90RSK and Nrf2 via the MEK1/2-ERK1/2 pathway to inhibit 6-OHDA-induced apoptotic damage in nerve cells. Notoginsenoside R2 upregulates SOX8/β-catenin by reducing miR-27a, thereby suppressing Aβ25-35-induced neuronal apoptosis and inflammatory responses . Notoginsenoside R2 alleviates lipid accumulation and mitochondrial dysfunction in diabetic nephropathy by inhibiting c-Src. Notoginsenoside R2 alleviates hepatic fibrosis by inducing hepatic stellate cell senescence and inhibiting the inflammatory microenvironment via JAK/STAT3 suppression . Notoginsenoside R2 can be used in research related to Parkinson's disease, Alzheimer's disease, diabetic nephropathy and hepatic fibrosis [2] .
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1 Cited Publications
Cat. No.: HY-132934
CAS No.: 2760674-72-2
Purity:  99.50%
Target:  

BCRP

Research Areas:  

Cancer

Ac32Az19 is a potent, nontoxic, and highly selective BCRP inhibitor with an EC50 value of 13 nM in the BCRP-overexpressed HEK293/R2 cells.
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1 Cited Publications
Cat. No.: HY-P72613
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IFNAR2; IFN-R-2; Prev. IFNABR; Interferon-Alpha/Beta Receptor Beta Chain; Interferon Alpha/Beta Receptor 2; Human Interferon Alpha/Beta Receptor; Type I Interferon Receptor 2; IFN-Alpha Binding Protein; Interferon (Alpha, Beta And Omega) Receptor 2; Inter
Species:  
Human
Source:  
HEK293
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1 Cited Publications
Cat. No.: HY-100013A1
CAS No.: 1609563-71-4
Purity:  98.08%
Target:  

GPR88

Research Areas:  

Neurological Disease

(1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC50 of 3 nM in cell-free assay, and 603 nM in cell assay.
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1 Cited Publications
Cat. No.: HY-124962
CAS No.: 35922-06-6
Purity:  99.74%
Synonyms: (1R,2R)-B13
Target:  

iGluR

Research Areas:  

Neurological Disease Cancer

D-NMAPPD ((1R,2R)-B13) is an acid ceramidase inhibitor. D-NMAPPD regulates NMDA receptor properties by enhancing endogenous production of ceramides. D-NMAPPD has anticancer effecs [2].
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1 Cited Publications
Cat. No.: HY-W021425
CAS No.: 5505-63-5
Synonyms: (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride
D-Mannosamine ((2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal) hydrochloride is a six-carbon amino sugar and an amino derivative of D-mannose. D-Mannosamine hydrochloride can block mannose receptors .
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1 Cited Publications
Cat. No.: HY-P76736
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ASGR2; HBXBP; Asialoglycoprotein Receptor 2; HL-2; CLEC4H2; ASGP-R 2; C-Type Lectin Domain Family 4 Member H2; ASGP-R2; HBxAg-Binding Protein; ASGPR 2; Hepatic Lectin H2; ASGPR2
Species:  
Human
Source:  
HEK293
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1 Cited Publications
Cat. No.: HY-15997
CAS No.: 114528-79-9
Synonyms: (-)-Trans-(1S,2S)-U-50488 hydrochloride
Target:  

Opioid Receptor

Research Areas:  

Infection Cancer

(-)-U-50488 hydrochloride ((-)-Trans-(1S,2S)-U-50488 hydrochloride) is a selective kappa-opioid receptor (KOR) agonist (Kd=2.2 nM) over μ-opioid receptor (MOR) (Kd=430 nM). (-)-U-50488 hydrochloride is a more active enantiomer than (+) trans-(1R,2R) U-50488 (HY-15997A) or the (±) trans-racemic mixture U-50488 (HY-15997B). (-)-U-50488 hydrochloride has a potent and sustained anti-HIV effect in fected blood monocyte-derived macrophages (MDM) .
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1 Cited Publications
Cat. No.: HY-103558
CAS No.: 191471-52-0
Purity:  99.84%
Target:  

mGluR

Research Areas:  

Neurological Disease

LY379268 is a potent, selective and brain-penetrant mGlu2/3R agonist with EC50 values of 2.69 nM (mGlu2) and 4.48 nM (mGlu3). LY379268 has no activity on human mGlu 1a, 4a, 5a or 7a receptors. LY379268 has antioxidant and neuroprotective effects [2].
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1 Cited Publications
Cat. No.: HY-P2221
CAS No.: 914009-86-2
Synonyms: ZP1848
Target:  

GCGR

Research Areas:  

Inflammation/Immunology

Glepaglutide (ZP1848), a long-acting GLP-2 analogue, is a potent GLP-2R agonist. Glepaglutide reduces faecal output and increases intestinal absorption. Glepaglutide alleviates small intestinal inflammation. Glepaglutide can be used in the research of inflammatory bowel disease (IBD) and Crohn’s disease [2] .
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1 Cited Publications
Cat. No.: HY-P2221B
Synonyms: ZP1848 acetate
Target:  

GCGR

Research Areas:  

Inflammation/Immunology

Glepaglutide (ZP1848) acetate, a long-acting GLP-2 analogue, is a potent GLP-2R agonist. Glepaglutide acetate reduces faecal output and increases intestinal absorption. Glepaglutide acetate alleviates small intestinal inflammation. Glepaglutide acetate can be used in the research of inflammatory bowel disease (IBD) and Crohn’s disease [2] .
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1 Cited Publications
Cat. No.: HY-100360
CAS No.: 1502816-23-0
Purity:  ≥98.0%
Research Areas:  

Cancer

MS049, a chemical probe, is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively. MS049 reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 is not toxic and does not affect the growth of HEK293 cells .
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1 Cited Publications
Cat. No.: HY-P3291
CAS No.: 2296814-85-0
Synonyms: ZP7570
Target:  

GCGR

Research Areas:  

Metabolic Disease

Dapiglutide (ZP7570) is a long-acting glucagon-like peptide-1 receptor 1R (GLP-1R)/Glucagon-like peptide-2 receptor (GLP-2R) dual agonist. Dapiglutide alleviates intestinal dysfunction in a mouse short bowel model and has anti-obesity effects [2] .
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1 Cited Publications
Cat. No.: HY-N2541
CAS No.: 122168-40-5
Gymnemic acid I is a bioactive triterpene saponin found in Gymnema sylvestre. Gymnemic acid I is an antisweetness inhibitor via human sweet receptor type 1 receptor 2 (T1R2) and T1R3. Gymnemic acid I is a ribosomal protein biosynthesis inhibitor. Gymnemic acid I has antidiabetic effects. Gymnema acid I induces autophagy-protected MIN-6 cells from apoptosis under high glucose stress by inhibiting the phosphorylation activity of mTOR [2].
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1 Cited Publications
Cat. No.: HY-P72831
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SERPINC1; Signal Peptide Antithrombin Part 1; Prev. AT3; Antithrombin III; ATIII; SERPINC1 Protein; Antithrombin-III; Antithrombin; Serine (Or Cysteine) Proteinase Inhibitor, Clade C (Antithrombin), Member 1; ATIII-R2; Serpin Peptidase Inhibitor, Clade C
Species:  
Human
Source:  
HEK293
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1 Cited Publications
Cat. No.: HY-P1205
CAS No.: 128315-56-0
Synonyms: Melanin-concentrating hormone(human, mouse, rat)
Target:  

MCHR1 (GPR24)

MCH (human, mouse, rat) is a cyclic neuropeptide mainly synthesized by neurons in the lateral hypothalamic area. MCH (human, mouse, rat) also serves as an endogenous ligand for the melanin-concentrating hormone receptor (MHC receptor), with a binding IC50 of 0.3 nM and 1.5 nM for human MCH-1R and MCH-2R, respectively; its functional EC50 values are 3.9 nM and 88.7 nM. MCH (human, mouse, rat) acts not only as an orexigenic signal but also as a key integrating and regulatory hormone for energy homeostasis and sleep-wake cycles. MCH (human, mouse, rat) can be used in studies related to obesity, sleep disorders, and other associated conditions [2] .
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1 Cited Publications
Cat. No.: HY-P1205A
Synonyms: Melanin-concentrating hormone(human, mouse, rat) TFA
Target:  

MCHR1 (GPR24)

MCH (human, mouse, rat) TFA is a cyclic neuropeptide mainly synthesized by neurons in the lateral hypothalamic area. MCH (human, mouse, rat) TFA also serves as an endogenous ligand for the melanin-concentrating hormone receptor (MHC receptor), with a binding IC50 of 0.3 nM and 1.5 nM for human MCH-1R and MCH-2R, respectively; its functional EC50 values are 3.9 nM and 88.7 nM. MCH (human, mouse, rat) TFA acts not only as an orexigenic signal but also as a key integrating and regulatory hormone for energy homeostasis and sleep-wake cycles. MCH (human, mouse, rat) TFA can be used in studies related to obesity, sleep disorders, and other associated conditions [2] .
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1 Cited Publications
Cat. No.: HY-P72025
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1B; TNF-R2; Prev. TNFR2; Tumor Necrosis Factor Receptor Superfamily, Member 1B; TNFBR; Tumor Necrosis Factor Receptor Superfamily, Member 1b; P75; Tumor Necrosis Factor Binding Protein 2; TNF-R-II; Tumor Necrosis Factor Beta Receptor; TNF-R75; Solub
Species:  
Human
Source:  
HEK293
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1 Cited Publications
Cat. No.: HY-P72599
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL10RB; CDW210B; Prev. D21S58; IL-10 Receptor Subunit Beta; Prev. D21S66; IL-10R Subunit Beta; Prev. CRFB4; IL-10R Subunit 2; IL-10R2; IL-10RB; CRF2-4; Cytokine Receptor Family II, Member 4; Interleukin-10 Receptor Subunit Beta; Cytokine Receptor Class-II
Species:  
Human
Source:  
HEK293
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