Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
48 Results for "
gamma-Secretase Modulators
" in MedChemExpress (MCE) Product Catalog:
Products (48)
48 Results for "gamma-Secretase Modulators" in MCE Product Catalog:
Target:
Forschungsgebiete:
FRM-024 is a central nervous system-penetrant, orally active γ-secretase modulator and Aβ42 lowering agent. FRM-024 is used for the research of familial Alzheimer's disease .
Art. -Nr.: HY-50889
CAS. Nr.: 1431697-84-5
Target:
Forschungsgebiete:
Gamma-secretase modulator 3 is a γ-secretase modulator. Gamma-secretase modulator 3 has the potential for use in research on neurological diseases such as Alzheimer's disease.
Art. -Nr.: HY-117957
CAS. Nr.: 1263871-36-8
Target:
Forschungsgebiete:
BMS-932481 is an orally active modulator for γ-secretase, selectively reduce Aβ1-42 and Aβ1-40 production, with IC50s of 6.6 and 25.3 nM, respectively .
Art. -Nr.: HY-103537A
CAS. Nr.: 1257396-73-8
Target:
Forschungsgebiete:
BIIB042 is a potent, orally active, brain-penetrant, and selective γ-secretase modulator (GSM). BIIB042 reduces Aβ42 and increases Aβ38 levels in cells. BIIB042 significantly reduces brain Aβ42 levels in CF-1 mice and Fischer rats, as well as plasma Aβ42 levels in cynomolgus monkeys. BIIB042 reduces Aβ42 levels and Aβ plaque burden in Tg2576 mice. BIIB042 can be used for alzheimer's disease (AD) research .
Art. -Nr.: HY-150050
CAS. Nr.: 1353570-53-2
Target:
Forschungsgebiete:
gamma-secretase modulator 5 (compound 22d) is a brain-penetrant gamma-secretase modulator (GSMs) that inhibits the production of the aggregated amyloid β-peptide Aβ42 with an IC50 value of 60 nM. gamma-secretase modulator 5 can be used in the study of Alzheimer's disease .
Art. -Nr.: HY-145372
CAS. Nr.: 2694817-84-8
Target:
Forschungsgebiete:
γ-Secretase modulator 10 is a novel γ-secretase modulator.
Art. -Nr.: HY-148306
CAS. Nr.: 1420200-85-6
Target:
Forschungsgebiete:
γ-Secretase modulator 14 is a γ-secretase modulator. γ-Secretase modulator 14 has the potenial for Alzheimer's disease (AD) research (WO2013010904A1; compound 42) .
Art. -Nr.: HY-147720A
CAS. Nr.: 2434630-30-3
Target:
Forschungsgebiete:
γ-Secretase modulator 11 hydrochloride (compound 1o) is a potent and orally active γ-secretase modulator with an IC50 of 0.029 µM. γ-Secretase modulator 11 hydrochloride induces a robust reduction in brain Aβ42 levels. γ-Secretase modulator 11 hydrochloride rescues cognitive deficits exhibited by AD model mice. γ-Secretase modulator 11 hydrochloride has the potential for the research of alzheimer's disease .
Art. -Nr.: HY-146151
CAS. Nr.: 2204249-82-9
Target:
Forschungsgebiete:
γ-Secretase modulator 12 (Compound 1a) is a γ-secretase modulator that can selectively decrease amyloid-β42 (Aβ42) levels (IC50 of 0.39 µM). γ-Secretase modulator 12 can be used for Alzheimer’s disease research. γ-Secretase modulator 12 has a good brain/plasma ratio (Kp, brain = 0.72) in mice .
Target:
Forschungsgebiete:
γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.014 μM and 0.017 μM in human and mouse, respectively .
Art. -Nr.: HY-112282
CAS. Nr.: 2231075-94-6
Target:
Forschungsgebiete:
BI-1408 is a potent γ secretase modulator with an IC50 of 0.04 μM for Aβ42 .
Target:
Forschungsgebiete:
(-)-FRM-024 is the (-)-isomer of FRM-024, a potent CNS-penetrant gamma secretase modulator that can be utilized in Alzheimer’s disease research .
Art. -Nr.: HY-19550
CAS. Nr.: 1402002-76-9
Target:
Forschungsgebiete:
PF-06442609 is an orally active γ secretase modulator, with an IC50 of 6 nM for Aβ42. PF-06442609 possesses brain good penetration .
Art. -Nr.: HY-103537
CAS. Nr.: 1257395-14-4
Target:
Forschungsgebiete:
(Rac)-BIIB042 (Compound 10) is an modulator of γ-Secretase. (Rac)-BIIB042 reduces Amyloid-β 42 level with an EC50 value of 0.39 µM. (Rac)-BIIB042 can be used for the study of Alzheimer's disease .
Target:
Forschungsgebiete:
Aβ42-IN-2 (compound example 36) is a γ-secretase modulator. Aβ42-IN-2 has an IC50 of 6.5 nM for Αβ42. Aβ42-IN-2 can be used for the research of Alzheimer's disease .
Art. -Nr.: HY-147720
CAS. Nr.: 2434630-29-0
Target:
Forschungsgebiete:
γ-Secretase modulator 11 (1o) showed high potency in vitro and brain exposure, inducing brain a β 42 levels were significantly reduced and showed undetectable inhibition of cytochrome P450 enzymes. In addition, compound 1o showed excellent anti cognitive deficit effect in AD model mice.
Art. -Nr.: HY-130609
CAS. Nr.: 2582757-69-3
Target:
Forschungsgebiete:
Aβ42-IN-1, compound 1v, is a novel, potent and orally active?γ-secretase modulator (GSM). Aβ42-IN-1 potently reduced Aβ42 levels with an IC50?value of 0.091?μM without CYP3A4 inhibition. Aβ42-IN-1 shows a sustained pharmacokinetic profile.
Art. -Nr.: HY-117482A
CAS. Nr.: 2436239-00-6
Target:
Forschungsgebiete:
BPN-15606 besylate is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 besylate lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice. BPN-15606 besylate has acceptable PK/PD properties, including bioavailability, half-life, and clearance .
Art. -Nr.: HY-14399R
CAS. Nr.: 749269-83-8
Synonyms: CHF5074 (Standard); CSP-1103 (Standard)
Target:
Forschungsgebiete:
Itanapraced (Standard) is the analytical standard of Itanapraced. This product is intended for research and analytical applications. Itanapraced (CHF5074) is an orally active γ-secretase modulator and a non-steroidal anti-inflammatory derivative. Itanapraced reduces Aβ42 and Aβ40 secretion with IC50 values of 3.6 and 18.4 μM, respectively. Itanapraced inhibits cell apoptosis of hippocampal neurons induced by oxygen and glucose deprivation (OGD). Itanapraced can be used for the research of Alzheimer's disease .
Art. -Nr.: HY-130609A
CAS. Nr.: 2434633-17-5
Target:
Forschungsgebiete:
Aβ42-IN-1 free base (compound 1v) is an orally active, high brain exposure γ-secretase modulator. Aβ42-IN-1 free base potently reduces Aβ42 levels with an IC50 value of 0.091 μM, and significantly reduces brain Aβ42 levels in mice. Aβ42-IN-1 free base is a promising compound for the treatment of Alzheimer’s disease .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
