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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
167 Results for "
intercalation
" in MedChemExpress (MCE) Product Catalog:
Products (167)
167 Results for "intercalation" in MCE Product Catalog:
1
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Crisnatol (BWA770U) is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts .
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1 Cited Publications
Synonyms: Methoxymorpholinyl doxorubicin; FCE 23762; PNU 152243
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Nemorubicin (Methoxymorpholinyl doxorubicin) is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity .
1
1 Cited Publications
Cat. No.: HY-D0163
CAS No.: 14855-76-6
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10-Methoxy-canthin-6-one (Mtx-C) is analkaloid derivative. 10-Methoxy-canthin-6-one can induce DNA damage by intercalating into DNA. 10-Methoxy-canthin-6-one can inhibit cancer cells proliferation, cause G2/M phase arrest and induce myeloid differentiation. T10-Methoxy-canthin-6-one can upregulate the expression of myeloperoxidase, CD15, CD11b, and CD14, as well as activation of p38 MAPK. 10-Methoxy-canthin-6-one also exhibits anti-bacterial activity. 10-Methoxy-canthin-6-one can be used for the researches of cancer and infection, such as acute myeloid leukemias (AML) .
1
1 Cited Publications
Cat. No.: HY-137265
CAS No.: 62442-61-9
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Aminomethyltrioxsalen hydrochloride is a psoralen derivative. Aminomethyltrioxsalen hydrochloride can penetrate intact cells and react with nucleic acid secondary structures in vivo without disrupting the tissue structure of natural nucleoproteins. Aminomethyltrioxsalen hydrochloride inactivates viruses by crosslinking nucleic acid pyrimidine residues after exposure to UV-A radiation. Aminomethyltrioxsalen hydrochloride can be used in research related to dengue virus infection .
Cat. No.: HY-W013967
CAS No.: 1720-32-7
Synonyms: Methyl docosahexaenoate; all cis-DHA methyl ester
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Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed.
Cat. No.: HY-U00248A
CAS No.: 308246-57-3
Synonyms: MJ-III65 hydrochloride; NSC706744 hydrochloride
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LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity .
Cat. No.: HY-W040198
CAS No.: 81-93-6
Cat. No.: HY-U00248
CAS No.: 308246-52-8
Synonyms: MJ-III65; NSC706744
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LMP744 (MJ-III65) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity .
Category:
Infection Quinones Anthraquinones Phenols Polyphenols Plants Solanaceae Disease Research Fields Rhizophora mucronata Lam
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Cat. No.: HY-D1322
CAS No.: 2375105-86-3
Cat. No.: HY-D1773
CAS No.: 156312-20-8
Synonyms: BQQ
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Benzoquinoquinoxaline (BQQ) is a heterocyclic compound with an aminoalkyl side chain. Benzoquinoquinoxaline preferentially binds to DNA triplex structures, intercalates between the bases, thus, stabilising the triplex conformation. Conjugation of Benzoquinoquinoxaline to 1,10-phenanthroline specifically binds and cleaves double strand DNA at the site of formation of a triplex structure .
Cat. No.: HY-13550
CAS No.: 64862-96-0
Synonyms: NSC 196473; NSC 290813
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Ametantrone (NSC 196473) is an antitumor agent that intercalates into DNA and induces topoisomerase II (TOP2)-mediated DNA break .
Synonyms: NSC 366140; PD 115934
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Pyrazoloacridine (NSC 366140), an intercalating agent with anti-cancer activity, inhibits the activity of topoisomerases 1 and 2. Pyrazoloacridine (NSC 366140) exhibits an IC50 of 1.25 μM in K562 myeloid leukemia cells for 24 h treatment .
Cat. No.: HY-167545
CAS No.: 10015-88-0
Synonyms: POPE
Cat. No.: HY-W111005
CAS No.: 1086-00-6
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1-Chloromethylpyrene is an alkylating agent that enters the DNA double helix structure through intercalation, forms covalent bonds with electrophilic groups, resulting in DNA cross-linking, thereby inhibiting the proliferation of tumor cells .
Cat. No.: HY-W110980
CAS No.: 613-13-8
Synonyms: Anthracen-2-amine; 2-Anthramine
Cat. No.: HY-13727
CAS No.: 144510-96-3
Synonyms: BBR 2778 free base
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Pixantrone (BBR 2778 (free base)), a mitoxantrone analog, is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
