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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
35 Results for "
outer mitochondrial membrane
" in MedChemExpress (MCE) Product Catalog:
Products (35)
35 Results for "outer mitochondrial membrane" in MCE Product Catalog:
Cat. No.: HY-17662
CAS No.: 512800-53-2
Synonyms: AK-918/41759663
Target:
Research Areas:
Mol4 (AK-918/41759663) is a highly selective BCL-2 protein inhibitor (IC50=153.3 μM). Mol4 induces mitochondrial outer membrane permeabilization (MOMP) and cytochrome c release, showing significant antiproliferative activity against glioblastoma (U87-MG) cell lines. Mol4 is promising for research of BCL-2-dependent tumors (e.g., chronic lymphocytic leukemia) .
Cat. No.: HY-P87115
Synonyms: FLJ9047 antibody; mitochondrial import receptor subunit TOM70 antibody; mitochondrial precursor proteins import receptor antibody; TOM70 antibody; TOM70_HUMAN antibody; Tomm70a antibody; Translocase of outer membrane 70 kDa subunit antibody; Translocase of outer membrane TOM70 antibody; Translocase of outer mitochondrial membrane 70 homolog A antibody;
Cat. No.: HY-P70136
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CYB5B; Cytochrome B5 outer mitochondrial membrane Isoform; Cytochrome B5 Type B; outer mitochondrial membrane Cytochrome B5; CYB5-M; Type 2 Cyt-B5; Cytochrome B5 Type B (outer mitochondrial membrane); CYPB5M; OMB5; CYB5M
Species:
Human
Source:
HEK293
Cat. No.: HY-P70941
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FIS1; mitochondrial Fission Molecule; Prev. TTC11; FIS1 Homolog; H_NH0132A01.6; HFis1; CGI-135; Fission 1 (mitochondrial outer membrane) Homolog (S. Cerevisiae); Tetratricopeptide Repeat Protein 11; Fission 1 (mitochondrial outer membrane) Homolog (Yeast)
Species:
Human
Source:
E. coli
Cat. No.: HY-L144
1,112 compounds
Normal mitochondrial function is critical for maintaining cellular homeostasis because mitochondria produce ATP and are the major intracellular source of free radicals. Cellular dysfunctions induced by intracellular or extracellular insults converge on mitochondria and induce a sudden increase in permeability on the inner mitochondrial membrane, the so-called mitochondrial membrane permeability transition (MMPT). MMPT is caused by the opening of pores in the inner mitochondrial membrane, matrix swelling, and outer membrane rupture. The MMPT is an endpoint to initiate cell death because the pore opening together with the release of mitochondrial cytochrome c activates the apoptotic pathway of caspases.
The normal operation of mitochondrial function is important for maintaining normal cell death and treatment of mitochondrial diseases. MCE offers a unique collection of 1,112 compounds with identified and potential mitochondrial protective activity. MCE Mitochondrial Protection Compound Library is critical for drug discovery and development.
Cat. No.: HY-P12011
Target:
Research Areas:
Cat. No.: HY-P87116
Synonyms: C19orf1 antibody; D19S1177E antibody; Haymaker protein antibody; mitochondrial import receptor subunit TOM40 homolog antibody; mitochondrial outer membrane protein antibody; mitochondrial outer membrane protein TOM40 antibody; p38.5 antibody; PER EC1 antibody; PEREC1 antibody; Probable mitochondrial import receptor subunit TOM40 homolog antibody; C19orf1 antibody; D19S1177E antibody; Haymaker protein antibody; mitochondrial import receptor subunit TOM40 homolog antibody
Cat. No.: HY-187706
CAS No.: 951529-42-3
Target:
Research Areas:
CDL36 is a BAX inhibitor with an EC50 of 23.6 µM. CDL36 inhibits pro-apoptotic peptide-induced mitochondrial outer membrane permeabilization (MOMP). CDL36 exerts cytoprotective effects against Doxorubicin (HY-15142A)-induced cell death .
Cat. No.: HY-103661R
CAS No.: 791835-21-7
Research Areas:
BI-6C9 (Standard) is the analytical standard of BI-6C9 (HY-103661). This product is intended for research and analytical applications. BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons .
Cat. No.: HY-P10614A
Target:
Research Areas:
Cat. No.: HY-100395R
CAS No.: 36098-33-6
Target:
Reference Standards Mitochondrial Metabolism Reactive Oxygen Species (ROS) Akt p38 MAPK Bcl-2 Family Apoptosis
Research Areas:
F16 (Standard) is the analytical standard of F16 (HY-100395). This product is intended for research and analytical applications. F16 is a mitochondrial permeability transition pore (PTP) modulator with an EC50 of 30 μM in mice. F16 promotes PTP opening, accumulates in cancer cell mitochondria, and induces mitochondrial depolarization, swelling, cristae disruption, outer membrane rupture, ATP depletion, reactive oxygen species (ROS) production, cytochrome c release and mitochondrial uncoupling. F16 induces cell cycle arrest at the G1 (occasionally G2) phase, reduces the phosphotyrosine content of Neu, as well as the levels of phosphorylated PKB/Akt and phosphorylated MAP kinase, downregulates the protein expression levels of Neu and PKB, triggers apoptosis in cells with moderate Bcl-2 expression, and induces necrosis in cells with overexpressed Bcl-2. F16 can be used in research related to breast cancer and gastric cancer .
Cat. No.: HY-P87278
Synonyms: hVDAC1 antibody; MGC111064 antibody; Mithocondrial porin antibody; OPM2, yeast, human complement of antibody; outer mitochondrial membrane protein porin 1 antibody; Plasmalemmal porin antibody; Porin 31 HL antibody; Porin 31 HM antibody; Porin 31HL antibody; Porin 31HM antibody
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
