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Cat. No.: HY-187706

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CDL36

CDL36 is a BAX inhibitor with an EC₅₀ of 23.6 µM. CDL36 inhibits pro-apoptotic peptide-induced mitochondrial outer membrane permeabilization (MOMP). CDL36 exerts cytoprotective effects against Doxorubicin (HY-15142A)-induced cell death.

For research use only. We do not sell to patients.

CAS No.: 951529-42-3
Formula: C₂₉H₃₂N₆O₂
Molecular Weight:496.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDL36 Chemical Structure

CAS No.: 951529-42-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target^[1]

Bax

23.6 μM (EC₅₀)

All Bcl-2 Family Isoforms :

In Vitro

CDL36 (39-5000 nM; 60 min) binds directly to recombinant BAX in a dose-dependent manner, disrupts the interaction between BAX and BAK-BH3 peptide, and produces detectable effects across the concentration range of 39 nM to 5000 nM^[1].
CDL36 binds to recombinant BAX protein as determined by microscale thermophoresis, with an EC₅₀ of 23.6 µM^[1].
CDL36 (1-100 µM) inhibits BIM peptide-induced mitochondrial outer membrane permeabilization (MOMP) in permeabilized lymphoma U937 cells^[1].
CDL36 (12.5-25 µM; 72 h) specifically protects intact CRISPR control cells and BAX knockout (KO) A549 cells against 5 µM Doxorubicin (HY-15142A)-induced cell death over a 72-hour treatment period^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 951529-42-3
Molecular Weight 496.60
Formula C₂₉H₃₂N₆O₂
SMILES

CN(C1=C2C=CC=C1)C=C2C3=NN(CCC4=O)C(N4CC(N(CC5)CCN5C6=CC=CC(C)=C6C)=O)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Inde Z, et al. A peptide-based screen for cell death inhibitors identifies the cytoprotective compound CDL36. bioRxiv [Preprint]. 2026 Jul 10:2026.07.09.737573.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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CDL36

All Bcl-2 Family Isoforms