257 Results for "

HO-1

" in MedChemExpress (MCE) Product Catalog:
Products (257)

257 Results for "HO-1" in MCE Product Catalog:

4
Hemoglobin
Hemoglobin
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4 Cited Publications
Referencia número: HY-P2995
No. CAS: 9008-02-0
Hemoglobin is a iron-containing protein in red blood cells with oxygen binding properties. Hemoglobin is an inducer of HO-1. Hemoglobin consits of heme, which binds to oxygen. Hemoglobin also transports other gases, such as carbon dioxide, nitric oxide, hydrogen sulfide and sulfide. Hemoglobin absorbs unneeded oxygen in tissues, as an antioxidant [1].
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Ethyl ferulate
Ethyl ferulate
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4 Cited Publications
Referencia número: HY-N0061
No. CAS: 4046-02-0
Category:  

Monophenols Simple Phenylpropanols Phenols Dicerothamnus rhinocerotis Phenylpropanoids Plants Umbelliferae

Target:  

Reactive Oxygen Species (ROS)

Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from Rhizoma Chuanxiong, induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress [1]. Ethyl ferulate also protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity .
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Rhamnocitrin
Rhamnocitrin
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4 Cited Publications
Referencia número: HY-N1353
No. CAS: 569-92-6
Category:  

Cardiovascular Disease Flavonols other families Flavonoids Phenols Polyphenols Plants Disease Research Fields

Target:  

Free Radical Scavengers p38 MAPK

Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3 and MAPK pathways and can scavenge DPPH (IC50=28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6, IL-8) and adhesion molecules (such as ICAM-1, VCAM-1). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells) [1] .
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3
AM-1638
AM-1638
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3 Cited Publications
Referencia número: HY-13467
No. CAS: 1142214-62-7
Pureza:  99.65%
Target:  

Free Fatty Acid Receptor

Áreas de investigación:  

Metabolic Disease

AM-1638 is an orally active full agonist of GPR40 (EC50: 0.16 μM). AM-1638 increases the expression of antioxidant molecules (HO-1 and NQO-1). AM1638 blocks Palmitate (HY-N0830)-mediated superoxide production and ER stress. AM-1638 has antidiabetic activity and improves glycemic control in BDF mice with diet-induced obesity (DIO). AM-1638 demonstrates excellent oral bioavailability (mouse, >100%; rat, 72%; and cyno, 71%) [1] .
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3
Oxyberberine
Oxyberberine
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3 Cited Publications
Referencia número: HY-N5027
No. CAS: 549-21-3
Synonyms: Oxyberberin; Berlambine; 8-Oxoberberine
Category:  

Infection Alkaloids Phellodendron amurense Rupr. Rutaceae Plants Disease Research Fields Isoquinoline Alkaloids

Target:  

Others

Oxyberberine (Oxyberberin; Berlambine) is an orally effective heme oxygenase HO-1 agonist that can activate antioxidant mechanisms by regulating the PI3K/Akt/AMPK signaling pathway. Oxyberberine induces HO-1 expression, increases SOD and GSH-Px activity, inhibits NF-κB-mediated inflammatory responses, and improves insulin sensitivity and glucose metabolism. Oxyberberine has anti-diabetic, neuroprotective, anti-inflammatory and antioxidant effects, and can be used to study type 2 diabetes, traumatic brain injury (TBI) and inflammatory bowel disease [1] .
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HO-1 Protein, Human
HO-1 Protein, Human
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3 Cited Publications
Referencia número: HY-P70276
Pureza:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HMOX1; Heme Oxygenase; Heme Oxygenase 1; HMOX1D; HO-1; HSP32; BK286B10; HO1; Heme Oxygenase (Decycling) 1; HO; Heat SHOck Protein, 32-KD
Species:  
Human
Source:  
E. coli
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Phosphocreatine
Phosphocreatine
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3 Cited Publications
Referencia número: HY-D0885
No. CAS: 67-07-2
Synonyms: Creatine pHOsphate; CreatinepHOspHOric acid
Category:  

Animals Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite MAP3K Akt Mitochondrial Metabolism ERK Apoptosis ROS Kinase

Phosphocreatine (creatine phosphate) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway. [1] .
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Phosphocreatine disodium
Phosphocreatine disodium
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3 Cited Publications
Referencia número: HY-D0885B
No. CAS: 922-32-7
Synonyms: Disodium creatine pHOsphate
Category:  

Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite MAP3K Akt Mitochondrial Metabolism ERK Apoptosis ROS Kinase

Phosphocreatine (disodium) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine (disodium) enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine (disodium) normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine (disodium) provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway. [1] .
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3
Phosphocreatine disodium hydrate
Phosphocreatine disodium hydrate
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3 Cited Publications
Referencia número: HY-D0885D
No. CAS: 19333-65-4
Category:  

Animals Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite MAP3K Akt Mitochondrial Metabolism ERK Apoptosis ROS Kinase

Phosphocreatine (disodium hydrate) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine (disodium hydrate) enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine (disodium hydrate) normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine (disodium hydrate) Phosphocreatine (disodium hydrate) provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway. [1] .
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3
Spinosin
Spinosin
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3 Cited Publications
Referencia número: HY-N0651
No. CAS: 72063-39-9
Category:  

Flavonoids Flavones Phenols Polyphenols Plants Actaea dahurica Turcz. ex Fisch. & C. A. Mey. Rhamnaceae

Target:  

Amyloid-β

Spinosyn is a kind of effective C-saccharide, which has a protective effect. Spinosyn is active through Nrf2/HO-1 pathway inhibition Aβ1-42's production and combination [1] [3 ].
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3
Gomisin J
Gomisin J
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3 Cited Publications
Referencia número: HY-N0385
No. CAS: 66280-25-9
Category:  

Cardiovascular Disease Monophenols Lignans Phenols Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill.

Target:  

NO Synthase AMPK CaMK NF-κB Keap1-Nrf2

Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIβ), fetuin-A, NF-κB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc [1] .
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3
Monotropein
Monotropein
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3 Cited Publications
Referencia número: HY-N0648
No. CAS: 5945-50-6
Category:  

Iridoids Pyrola calliantha H. Andr. Terpenoids Pyrolaceae Rubiaceae Plants Morinda officinalis How Disease Research Fields Inflammation/Immunology

Target:  

Interleukin Related Keap1-Nrf2 Heme Oxygenase (HO) NF-κB Apoptosis

Monotropein is an iridoid glycoside that can be isolated from the roots of Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS)-induced colitis mouse model. Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes. Monotropein has cartilage protective activity. Monotropein can alleviate Cisplatin (HY-17394)-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis through activation of Nrf2/HO-1 pathway and inhibition of NF-κB signaling. Monotropein can be studied in research for osteoarthritis, acute kidney injury and acute lung injury [1] .
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2
Solanesol
Solanesol
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2 Cited Publications
Referencia número: HY-N0576
No. CAS: 13190-97-1
Category:  

Other Terpenoids other families Neurological Disease Terpenoids Plants Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite Heme Oxygenase (HO) HSP p38 MAPK Akt Apoptosis Caspase PARP

Solanesol is an orally active aliphatic terpene alcohol. Solanesol is mainly found in tobacco and other Solanaceae plants. Solanesol induces HO-1 and Hsp70 expression, activates p38 and Akt signaling pathways, and inhibits Apoptosis (reduces caspase-3 and PARP cleavage). Solanesol has antioxidant, anti-inflammatory, and neuroprotective activities. Solanesol can be used in the research of Huntington's disease, alcoholic liver disease, chronic inflammatory pain, anxiety, Alzheimer's disease, and bipolar disorder [1] .
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2
Coenzyme Q0
Coenzyme Q0
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2 Cited Publications
Referencia número: HY-W016412
No. CAS: 605-94-7
Synonyms: CoQ0
Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling [1] .
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2
4-Hydroxyphenyl acetate
4-Hydroxyphenyl acetate
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2 Cited Publications
Referencia número: HY-30267
No. CAS: 3233-32-7
Synonyms: 4-HPA; 4-Acetoxyphenol
Category:  

Monophenols Other Diseases Phenols Endogenous metabolite Disease Research Fields

Target:  

Quinone Reductase Endogenous Metabolite

4-Hydroxyphenyl acetate (4-HPA) is a natural antioxidant and protects cells from oxidative stress-induced necrosis. 4-Hydroxyphenyl acetate blocks the increase of cellular ROS induced by oxidative stress, and up-regulates NQO1 and HO-1 genes by stabilizing and inducing the nuclear translocation of NRF2 transcription factor [1].
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2
Sofalcone
Sofalcone
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2 Cited Publications
Referencia número: HY-B2184
No. CAS: 64506-49-6
Target:  

Autophagy Bacterial

Áreas de investigación:  

Infection Inflammation/Immunology

Sofalcone, a gastric antiulcer agent, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
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5,7-Dihydroxychromone
5,7-Dihydroxychromone
0 Images
2 Cited Publications
Referencia número: HY-N1970
No. CAS: 31721-94-5
Category:  

other families Flavonoids Phenols Polyphenols Plants Isoflavones

Target:  

Keap1-Nrf2 Caspase PARP Fungal

5,7-Dihydroxychromone is a flavonoid compound with antioxidant properties. 5,7-Dihydroxychromone induces Nrf2 nuclear translocation, increases Nrf2/ARE binding activity, and up-regulates Nrf2-dependent antioxidant genes HO-1, NQO1, GCLc. 5,7-Dihydroxychromone attenuates excessive ROS generation, inhibits activated caspase-3, caspase-9, cleaved PARP expression, and prevents neuronal apoptosis and cell death. 5,7-Dihydroxychromone increases LXRα and PPARγ mRNA expression, induces preadipocyte differentiation, and regulates blood glucose levels. 5,7-Dihydroxychromone inhibits radial growth of soil pathogenic fungi, radicle elongation of select seedlings, and transiently inhibits Bradyrhizobium sp. growth in high mannitol medium. 5,7-Dihydroxychromone can be used for the research of Parkinson’s disease, type 2 diabetes mellitus and pathogenic fungal infection [1] .
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OB-24
OB-24
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2 Cited Publications
Referencia número: HY-118487
No. CAS: 939825-12-4
Pureza:  98.03%
Target:  

Heme Oxygenase (HO) Reactive Oxygen Species (ROS)

Áreas de investigación:  

Cancer

OB-24 is a selective small-molecule HO-1 inhibitor (IC50 = 1.9 μM for HO-1 and IC50 for HO-2 >100 μM). OB-24 possesses anti-tumor and anti-metastatic properties. OB-24 can be studies in research such as prostate cancer, melanoma, ovarian carcinoma and lung metastasis [1] .
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DI-1859
DI-1859
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2 Cited Publications
Referencia número: HY-145733
No. CAS: 2247061-09-0
Pureza:  99.62%
Target:  

E1/E2/E3 Enzyme Keap1-Nrf2 Reactive Oxygen Species (ROS) Insulin Receptor Akt

Áreas de investigación:  

Metabolic Disease Cancer

DI-1859 is a DCN1 and cullin 3 inhibitor with a Ki of <1 nM against human DCN1. DI-1859 forms a covalent bond with Cys115 of DCN1, cleaves its dimethylamino group, disrupts the DCN1-UBC12 interaction, and selectively inhibits the neddylation modification of cullin 3 relative to other cullins. DI-1859 inactivates CRL3, promotes the accumulation of NRF2 and SLC7A11, upregulates the expression of HO-1 and NQO1, reduces reactive oxygen species (ROS) levels, enhances insulin signaling, promotes insulin secretion, activates RhoA, regulates the phosphorylation of AKT, without completely blocking the neddylation modification of cullin 3 or restoring the expression of IRS-1. DI-1859 can be used in the research of Acetaminophen (HY-66005)-induced hepatotoxicity, hyperglycemia, metabolic dysfunction-associated steatotic liver disease, insulin resistance, breast cancer and lung cancer [1] .
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Dihydrolipoic Acid
Dihydrolipoic Acid
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2 Cited Publications
Referencia número: HY-116807
No. CAS: 462-20-4
Pureza:  99.95%
Synonyms: DHLA
Category:  

Microorganisms Ketones, Aldehydes, Acids

Target:  

Reactive Oxygen Species (ROS)

Dihydrolipoic Acid (DHLA) is an excellent antioxidant capable of scavenging almost any oxygen-centered radical [1]. Dihydrolipoic acid exhibits anti-inflammatory properties in various diseases. Dihydrolipoic Acid exerts a preventive effect via ERK/Nrf2/HO-1/ROS/NLRP3 pathway in LPS-induced sickness behavior rats. Dihydrolipoic Acid can be used for the reaserch of depression .
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