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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
67 Results for "
Cryptococcus
" in MedChemExpress (MCE) Product Catalog:
Products (67)
67 Results for "Cryptococcus" in MCE Product Catalog:
Cat. No.: HY-169919
CAS No.: 3020690-76-7
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HDM-IN-1 (Compound A4) is an inhibitor for fungal histone demethylase (HDM), that inhibits the H3K27me3 in Cryptococcus neoformans and in Candida auris with IC50s of 134 and 12 nM. HDM-IN-1 exhibits inhibitory efficacy against C. neoformans and C. auris with MIC80 of 0.5-2 μg/mL, through inhibition of the biofilm and capsule formation. HDM-IN-1 exhibits antifungal activity in ICR mouse model .
Cat. No.: HY-169119
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Antifungal agent 114 (Compound 19g) is an inhibitor for Cytochrome P450, that inhibits CYP1A2, CYP2C9, CYP2C19 CYP2D6 and CYP3A4 at 10 μM. Antifungal agent 114 exhibits antifungal activity against Cryptococcus neoformans, Candida and Aspergillus, with MIC <0.0625 μg/mL. Antifungal agent 114 exhibits good metabolic stability in human liver microsomes with a half-time of 107 minutes .
Cat. No.: HY-173428
Antifungal agent 130 (Compound A7) is an orally active antifungal agent. Antifungal agent 130 has good antifungal activity against Candida albicans (MIC = 0.12 ng/mL) and Cryptococcus neoformans (MIC = 0.12 ng/mL) and has excellent antivirulence effect. Antifungal agent 130 exerts its antifungal effect by disrupting the iron homeostasis of fungal cells and inducing oxidative stress damage. Antifungal agent 130 can inhibit the formation of fungal virulence factors (such as biofilm, capsule, urease and melanin). Antifungal agent 130 has good antifungal effect and can be used in the study of drug-resistant fungal infections .
Cat. No.: HY-181101
CAS No.: 3097563-43-1
Antifungal agent 151 is a Prp8 intein inhibitor that inhibits the self-splicing process of the Prp8 intein, preventing maturation of the Prp8 protein. Antifungal agent 151 exerts in vitro antifungal activity against Cryptococcus neoformans and Cryptococcus gattii. Antifungal agent 151 can be used for the research of cryptococcus pneumonia .
Cat. No.: HY-184981
CAS No.: 2243516-99-4
Urease-IN-24 is a cryptococcal urease inhibitor with a IC50 of 89.96 nM and a Ki of 64.3 nM. Urease-IN-24 acts as a competitive nickel-coordinating inhibitor that coordinates with the nickel center at the catalytic site of the enzyme via its carbonyl group. Urease-IN-24 reduces the capsule thickness of Cryptococcus neoformans and Cryptococcus gattii, increases cell membrane permeability, and inhibits melanin production. Urease-IN-24 exhibits fungicidal activity against Cryptococcus species. Urease-IN-24 can be used in the research of cryptococcosis .
Cat. No.: HY-DY2048
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India Ink is a negative staining agent. India Ink creates contrast against the polysaccharide capsule of Cryptococcus neoformans to enable visualization. India Ink enables automated measurement of Cryptococcus neoformans capsule diameter using computational image analysis. India Ink can be used for the research of cryptococcosis .
Cat. No.: HY-181784
Ac-CoA-IN-1 is an acyl-AMP phosphate analog and weak inhibitor of Candida albicans acetyl-CoA synthetase 2, with no activity against Cryptococcus neoformans acetyl-CoA synthetase 1. Ac-CoA-IN-1 crystallizes with Cryptococcus neoformans ACS1 enzyme to yield structural insight for inhibitor design. Ac-CoA-IN-1 can be used for the research of fungal infections .
Cat. No.: HY-N14012
CAS No.: 363624-70-8
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Cat. No.: HY-N14547
CAS No.: 21284-11-7
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Cat. No.: HY-N19644
CAS No.: 884604-98-2
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Cat. No.: HY-184735
CAS No.: 2924270-62-0
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Antifungal agent-170 is an Antifungal agent. Antifungal agent-170 potently inhibits the growth of recombinant Saccharomyces cerevisiae strains expressing wild-type and mutant fungal CYP51 enzymes. Antifungal agent-170 potently inhibits the growth of Candida albicans, Candida glabrata, Candida krusei, Cryptococcus neoformans and Cryptococcus gattii. Antifungal agent-170 provides survival benefits in the Galleria mellonella (greater wax moth) infection model. Antifungal agent-170 can be used for the research of invasive fungal infections .
Cat. No.: HY-124384
CAS No.: 1159392-22-9
Synonyms: Soudanone A
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Cat. No.: HY-179704
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Antifungal agent 141, a Phenoxazine (HY-34463) derivative, is an antifungal agent. Antifungal agent shows potent antifungal activity in Cryptococcus neoformans and Candida albicans with MIC values of 2 and 4 µg/mL. Antifungal agent 141 can be used for the research of cryptococcal meningitis .
Cat. No.: HY-184980
CAS No.: 2180967-88-6
Urease-IN-23 is a cryptococcal urease inhibitor with antifungal activity. AF55 exhibits mixed-type inhibition against cryptococcal urease, binds to both the nickel ion site at the enzyme's catalytic center and the allosteric site, impairs urease catalytic efficiency, simultaneously disrupts fungal virulence structures and damages cell membrane integrity. The IC50 and Ki values of Urease-IN-23 against cryptococcal urease are 54.92 nM and 149.1 nM, respectively. Urease-IN-23 significantly reduces the capsule thickness of Cryptococcus neoformans and Cryptococcus gattii, increases fungal cell membrane permeability, and completely blocks melanin synthesis. Urease-IN-23 shows no toxicity in the Galleria mellonella larval model. Urease-IN-23 can be used in studies related to fungal infections .
Cat. No.: HY-N18222
CAS No.: 34490-82-9
Cat. No.: HY-N9869
CAS No.: 1197343-17-1
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Platanus occidentalis L. Phenols Polyphenols Plants Platanaceae Extract Saccharides Monosaccharides
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Cat. No.: HY-119726B
Fosmanogepix TFA (APX001 TFA) is an orally active APX001A (HY-18233) prodrug and antifungal agent. Fosmanogepix TFA is effective against Cryptococcus neoformans, Fluconazole (HY-B0101)-resistant C. auris. Fosmanogepix TFA is effective in the treatment of invasive pulmonary aspergillosis and pulmonary murine mucormycosis .
Cat. No.: HY-136755
CAS No.: 1155361-03-7
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CYP51-IN-5 is a cytochrome P450 14α-demethylase (CYP51) inhibitor and an antifungal (fungal) agent belonging to the triazole derivative class. CYP51-IN-5 is applicable to the research of Candida albicans, Cryptococcus neoformans, Candida parapsilosis, Candida tropicalis, Trichophyton rubrum, Candida krusei and Microsporum gypseum .
Cat. No.: HY-W069116
CAS No.: 174671-88-6
Antifungal agent 146 (Compound 19l) is a broad-spectrum antifungal agent. Antifungal agent 146 has inhibitory effects on the main dermatophytes that cause onychomycosis (Trichophyton rubrum, Trichophyton mentagrophytes) and other fungi (Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus) with MIC values of 16, 16, 64, 32, and 32 μg/mL. Antifungal agent 146 can be used for the research of infection .
Cat. No.: HY-136753
CAS No.: 1155361-01-5
Antifungal agent-162 (Compound 1c) is an Antifungal agent. Antifungal agent-162 exhibits potent in vitro antifungal activity against Candida albicans, Cryptococcus neoformans, Candida parapsilosis, Candida tropicalis, Candida krusei, and Microsporum gypseum (with MIC80 values ranging from 0.0156 to 0.25 μg/mL), while shows no activity against Aspergillus fumigatus .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
