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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
157 Results for "
duration
" in MedChemExpress (MCE) Product Catalog:
Products (157)
157 Results for "duration" in MCE Product Catalog:
Cat. No.: HY-B0615AS
CAS No.: 2300178-76-9
Synonyms: EN 313-d8; Ethmozin-d8; Moracizine-d8
Cat. No.: HY-12532S
CAS No.: 1189961-39-4
Synonyms: SCV 07; Gamma-D-glutamyl-L-tryptophan
Research Areas:
Cat. No.: HY-10419
CAS No.: 81443-73-4
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AH23848 (compound 6) is a competitive blocker of the thromboxane A2 receptor and an orally effective agent, with an IC50 value of 50 nM against human targets and a long duration of action.
Cat. No.: HY-A0225B
CAS No.: 38029-10-6
Synonyms: (±)-Pirbuteroldihydrochloride; ARA 211dihydrochloride
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Pirbuterol ((±)-Pirbuterol) dihydrochloride is a beta 2 adrenergic agonist with bronchodilator activity. Pirbuterol dihydrochloride is comparable in duration of action to albuterol when administered by inhalation. Pirbuterol dihydrochloride demonstrates similar beta 2 selectivity to albuterol in humans.
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L-3373 is a voltage-dependent potassium channel inhibitor with activity that reduces the effective refractory period and the dispersion of monophasic action potential duration, while significantly reducing susceptibility to ventricular fibrillation in a cat model of left ventricular hypertrophy.
Cat. No.: HY-B1470S
CAS No.: 1173021-72-1
Synonyms: R-1929-d4
Cat. No.: HY-19097
CAS No.: 125030-71-9
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Ro 24-4736 is a potent, selective, p.o.-active platelet-activating factor (PAF) antagonist with a long duration of action. Ro-24-4736 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-177311
CAS No.: 1080018-61-6
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NVP-QBE170 is a selective Epithelial sodium channel (ENaC) inhibitor with an IC50 of 57.5 nM. NVP-QBE170 potently inhibits ENaC function in HBECs and shows a longer duration of action. NVP-QBE170 significantly attenuates ENaC activity in the airways of guinea pig models. NVP-QBE170 can be used for hyperkalaemia research .
Synonyms: NLX-112 hydrochloride; F 13640 hydrochloride
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Befiradol (NLX-112) hydrochloride is a highly selective 5-HT1A receptor agonist that acts on both presynaptic and postsynaptic sites. Befiradol hydrochloride attenuates sedative agent-induced respiratory depression in neonatal and adult rats. Befiradol reduces the duration of sedative agent-induced analgesia and sedation in adult rats. Befiradol hydrochloride can be used in studies related to opioid-induced respiratory depression .
Cat. No.: HY-P99913
CAS No.: 1384099-30-2
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Cat. No.: HY-12532R
CAS No.: 68844-77-9
Synonyms: R 43512 (Standard)
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Astemizole (Standard) is the analytical standard of Astemizole. This product is intended for research and analytical applications. Astemizole (R 43512), a second-generation antihistamine agent to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC50 of 4 nM. Astemizole also shows potent hERG K + channel blocking activity with an IC50 of 0.9 nM. Astemizole has antipruritic effects .
Cat. No.: HY-17504C
CAS No.: 1094100-06-7
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(3R,5R)-Rosuvastatin is a hERG potassium channel blocker and HMG-CoA reductase inhibitor that prolongs the action potential duration and QT interval by accelerating channel inactivation, impairing channel folding, reducing hERG mRNA transcription, and promoting the degradation of mature and immature hERG channels. (3R,5R)-Rosuvastatin can be used for research on long QT syndrome .
Cat. No.: HY-12909
CAS No.: 1207745-58-1
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MK-4409 is an orally active and blood-brain barrier-penetrant fatty acid amide hydrolase (FAAH) inhibitor (human IC50 = 11 nM; rat IC50 = 11 nM) that reversibly and non-covalently inhibits this serine hydrolase, elevating endogenous fatty acid ethanolamides. MK-4409 alleviates inflammatory and neuropathic pain, with a long duration of action, and reduces edema. MK-4409 can be used for research on inflammatory and neuropathic pain .
Synonyms: MG-13054
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Fenquizone (MG-13054) is an orally active diuretic. Fenquizone acts primarily on the diluting segment of the nephron cortex, similar to thiazide diuretics. Fenquizone demonstrates diuretic and natriuretic potency and duration of action comparable to thiazide diuretics but weaker than loop diuretics. Fenquizone reduces CH₂O without affecting TCH₂O, does not increase calcium/phosphate excretion, and has no loop or collecting duct effects. Fenquizone is used in the study of edema and hypertension .
Cat. No.: HY-164519
CAS No.: 2771955-09-8
PF-7006 is an Mps1 kinase inhibitor with a Ki value of 0.27 nM and an IC50 value of 2.5 nM. PF-7006 interferes with cell cycle checkpoints by inhibiting the catalytic activity of Mps1, reducing histone H3 levels, and shortening the duration of mitosis, leading to apoptosis in cancer cells. Combined use of PF-7006 with Palbociclib (HY-50767) increases cancer cell tolerance to PF-7006. PF-7006 can be used for breast cancer research .
Cat. No.: HY-120926
CAS No.: 118587-22-7
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BBR 2160 is a compound with cardiac electrophysiological effects and is a dihydropyridine calcium antagonist that can reduce myocardial contractility and action potential duration and has calcium antagonist properties.
Cat. No.: HY-106682
CAS No.: 77862-92-1
Synonyms: AQ-A 39
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Falipamil (AQ-A 39), a calcium channel blocker, is a bradycardic agent. The bradycardic effect results from a reduction in the diastolic depolarization rate and a prolongation of the action potential duration .
Cat. No.: HY-B0546AS
Cat. No.: HY-165524
CAS No.: 178894-81-0
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AM 92016 is a potassium channel blocker. AM 92016 can increase the duration of action potentials in isolated ventricular cells from guinea pigs and rabbits. AM 92016 has proarrhythmic activity in guinea pigs and pigs .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
