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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
60 Results for "
feces
" in MedChemExpress (MCE) Product Catalog:
Products (60)
60 Results for "feces" in MCE Product Catalog:
Cat. No.: HY-133813S
Arsthinenol (Arsthinol; Balarsen) is an orally active small organic arsenic molecule. Arsthinenol exhibits anti-amoebic activity by eliminating cysts and trophozoites of Entamoeba histolytica in feces and promoting the healing of amoebic rectal ulcers. Arsthinenol forms the hydroxypropyl-β-cyclodextrin inclusion complex STB-HPβCD, which has an IC50 of 31.6 μM against U87 MG cells and possesses anti-tumor activity. Arsthinenol can be used in the research of intestinal amoebiasis and glioblastoma .
Cat. No.: HY-W399297R
CAS No.: 566-17-6
Synonyms: 7α,12α-Dihydroxycholanoic acid (Standard)
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Cat. No.: HY-W004305R
CAS No.: 629-80-1
Synonyms: Palmitaldehyde (Standard)
Cat. No.: HY-137263
CAS No.: 35775-65-6
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Propionylmaridomycin is a macrolide antibiotic with antibacterial activity. Propionylmaridomycin is rapidly absorbed from the gastrointestinal tract and rapidly distributed to tissues. Propionylmaridomycin radioactivity levels in the liver, kidneys, and lungs were significantly higher than in plasma, while distribution to the brain was less. Propionylmaridomycin is excreted primarily through the feces, and the high fecal recovery rate is due to unabsorbed compounds and biliary excretion of compounds and their metabolites. Propionylmaridomycin exhibits the highest antibacterial activity in the lungs. Propionylmaridomycin is completely converted to several metabolites in rats, of which 4''-depropionyl-9-propionylmaridomycin was identified as the major metabolite .
Cat. No.: HY-W004305S
CAS No.: 2703602-66-6
Synonyms: Palmitaldehyde-d5
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Hexadecanal-d5 (Palmitaldehyde-d5) is deuterium labeled Hexadecanal. Hexadecanal (Palmitaldehyde) , a volatile long-chain aliphatic aldehyde, is emitted from human feces, skin, and breath. The receptor for hexadecanal(OR37B) is highly conserved across mammals. Hexadecanal may exert its effects by modulating functional connectivity between the brain substrates of social appraisal and the brain substrates of aggressive execution. Also, Hexadecanal is confirmed to be highly deterrent to the ant Lasius niger. Hexadecanal is promising for the research of startle responses and aggression
Cat. No.: HY-W782193
CAS No.: 55320-91-7
Synonyms: 6-Methyl-5-hepten-2-one-d5
Cat. No.: HY-W010516R
CAS No.: 97-61-0
Synonyms: 2-Methylpentanoic acid (Standard)
Cat. No.: HY-B0937S
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Amprolium-d7 (bromide hydrobromide) is the deuterated-labeled Amprolium (HY-B0937). Amprolium is a thiamine transporter inhibitor and antiparasitic agent with oral activity and blood-brain barrier penetration. Amprolium blocks thiamine transport at the blood-brain barrier and intestine, and competitively inhibits thiamine pyrophosphokinase, inducing thiamine pyrophosphate deficiency and impairing carbohydrate synthesis. Amprolium induces oxidative stress, alters antioxidant enzyme activity, and inhibits acetylcholinesterase (AchE) activity. Amprolium disrupts reproductive organs and gametogenesis, and causes histopathological and ultrastructural damage to multiple organs. Amprolium induces thiamine deficiency, reduces body weight gain in mice, and causes psychomotor behavioral changes and nephropathy. Amprolium exhibits molluscicidal activity against the terrestrial snail Eobania vermiculata, and reduces the shedding of Eimeria meleagrimitis oocysts in feces and litter. Amprolium can be used for research on thiamine deficiency and coccidiosis .
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Temephos (Standard) is the analytical standard of Temephos. This product is intended for research and analytical applications. Temephos (Temefos) is an orally active, blood-brain barrier-permeable organophosphate insecticide and AChE inhibitor. By irreversibly inhibiting AChE to induce cholinergic overactivation, Temephos effectively blocks larval development of Aedes aegypti (yellow fever mosquito) and Aedes albopictus (Asian tiger mosquito), and is commonly used in studies related to Dengue Virus, Zika Virus and other relevant pathogens. Temephos exhibits genotoxicity and neurodevelopmental toxicity, and may also cause liver injury, reproductive system abnormalities and cholinergic poisoning symptoms in mammals. Temephos tends to accumulate in adipose tissues and aquatic organisms, and is excreted via feces after metabolism through oxidation and hydrolysis. Note that CYP-mediated metabolic detoxification may reduce the actual larvicidal efficacy of Temephos against some mosquito species. Temephos can be used in research related to dengue fever, Zika virus disease, chikungunya and dracunculiasis .
Cat. No.: HY-B1120S
CAS No.: 1219795-39-7
Synonyms: Temefos-d12
Cat. No.: HY-W740426
CAS No.: 190710-79-3
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N-Desmethyltopotecan is a metabolite of Topotecan (HY-13768), and it can be detected in plasma, urine and feces .
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Cat. No.: HY-120422
CAS No.: 1343498-72-5
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N-Desmethyl Regorafenib is a demethylated metabolite of Regorafenib (HY-10331), formed by N-demethylation, and is found in feces and occasionally in plasma as a trace component. N-Desmethyl Regorafenib is a substrate for amide hydrolysis .
Cat. No.: HY-156126
CAS No.: 1808096-68-5
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Cat. No.: HY-133813
CAS No.: 27773-65-5
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Apovincaminic acid is the major metabolite of Vinpocetine (HY-13295), with blood-brain barrier permeability and oral activity. Apovincaminic acid is detectable in the plasma of pregnant rabbits after oral administration of Vinpocetine. Apovincaminic acid is absorbable from all segments of the gastrointestinal tract of Norway rat, with the stomach as the primary absorption site, and is excreted via urine and feces. Apovincaminic acid is used in the research of cerebrovascular diseases .
Stilbazium iodide is an orally effective pyridinium quaternary ammonium repellent. Stilbazium (iodide) exhibits broad-spectrum activity against a variety of human and animal intestinal parasites. Stilbazium iodide eliminates both mature and immature worms, reduces egg counts, reddens feces, and causes mild gastrointestinal irritation. Stilbazium iodide can be used in research related to intestinal parasitic infections including pinworm, whipworm, and strongyloidiasis .
Cat. No.: HY-W007355S2
Synonyms: 3-Methylindole-13C6; 3-Methyl-1H-indole-13C6
Cat. No.: HY-138135
CAS No.: 1030825-28-5
Synonyms: Fidaxomicin metabolite OP-1118
OP-1118 (Fidaxomicin metabolite OP-1118) is an orally active dual inhibitor of NF-κB and ERK1/2, with low systemic plasma exposure, no accumulation, and primary excretion via feces. By inhibiting the phosphorylation of NF-κB and ERK1/2 and reducing the expression of pro-inflammatory cytokines, OP-1118 exerts significant anti-inflammatory, cytoprotective, anti-apoptotic and antibacterial activities. In Clostridium difficile infection models, OP-1118 effectively blocks toxin-mediated intestinal inflammation, cell rounding, histological damage and apoptosis, and its protective effect can be reversed by PMA (HY-18739) .
Cat. No.: HY-16265A
CAS No.: 2514957-81-2
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JI-101 hydrochloride is an orally active angiogenesis inhibitor and anticancer agent with 55% oral bioavailability in Sprague Dawley rats, high permeability, and no P-gp substrate activity .JI-101 hydrochloride modulates angiogenesis signaling pathways in tumor vessel beds, downregulates EphB4, targets EphB4, VEGFR-2, and PDGFR-β, and inhibits multiple stages of tumor angiogenesis .JI-101 hydrochloride exerts activity against cancer cells and xenografts, exhibits mild to moderate inhibition of CYP3A4, and shows stability in pre-clinical and human liver microsomes .JI-101 hydrochloride undergoes rapid oral absorption in Sprague Dawley rats, has extensive tissue distribution with preferred lung uptake, and is excreted via bile with mono- and di-hydroxy metabolites, with feces as the primary elimination route .JI-101 hydrochloride can be used for the research of ovarian cancer and solid tumors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
