Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
400 Results for "
thyroid
" in MedChemExpress (MCE) Product Catalog:
Products (400)
400 Results for "thyroid" in MCE Product Catalog:
1
Target:
Forschungsgebiete:
3,5-Diiodothyropropionic acid is a thyroid hormone analog, induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (TR), with Ka of 2.40 and 4.06 M -1 for TRα1 and TRβ1, respectively. 3,5-Diiodothyropropionic acid promotes angiogenesis in 3-D human dermal microvascular endothelial cell sprouting assay. 3,5-Diiodothyropropionic acid prevents myocardial arteriolar loss in thyroidectomized rats and enhances cardiac energy-generating capacity in postinfarction heart failure rats. 3,5-Diiodothyropropionic can be used in studies related to angiogenesis and heart failure .
1
1 Cited Publications
ZY-444 is an anti-cancer agent, targeting pyruvate carboxylase (PC). ZY-444 suppresses the Wnt/β-catenin/Snail signaling pathway by blocking nuclear translocation of β-catenin. ZY-444 selectively inhibits proliferation, migration, and invasion and induces apoptosis in cancer cells. ZY-444 exhibits potent anti-tumor in cancer mouse models. ZY-444 can be used for the study of breast cancer, lung cancer (NSCLC), prostate cancer and iodine-refractory thyroid cancer .
1
Forschungsgebiete:
Sulisobenzone (Benzophenone-4) is a benzophenone-type UV filter. Sulisobenzone can act as a endocrine disrupting compound. Sulisobenzone disrupts energy metabolism, nucleotide synthesis, oxidative stress response, and endocrine function. Sulisobenzone thyroid hormone biosynthesis and induces oxidative stress .
1
1 Cited Publications
Art. -Nr.: HY-N6841
CAS. Nr.: 86831-53-0
1
1 Cited Publications
Target:
Forschungsgebiete:
CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation .
1
1
Target:
Forschungsgebiete:
Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Thyrotropin (TSH, Pretiron) is a thyroid-stimulating hormone produced by thyrotrope cells in the anterior pituitary gland. Thyrotropin regulates the endocrine function of the thyroid. Thyrotropin induces transcriptional regulation of TH-gatekeeper genes in tanycytes through the Tshr/Gαq/PKC pathway. Thyrotropin prevents Apoptosis. Thyrotropin has an association of low levels with increased bone remodeling, reduced bone mass and a high fracture risk in mice. Thyrotropin is promising for research of skeletal remodeling, hyperthyroidism .
1
1 Cited Publications
Art. -Nr.: HY-P99364
CAS. Nr.: 1024603-92-6
Synonyms: Anti-VEGFR1/FLT1 Reference Antibody; IMC-18F1
1
Target:
1
1 Cited Publications
Synonyms: Aminourea hydrochloride; Hydrazinecarboxamide hydrochloride
Target:
Forschungsgebiete:
Semicarbazide hydrochloride is an orally active urea derivative. Semicarbazide hydrochloride binds to copper or iron in cells. Semicarbazide hydrochloride inhibits the activity of soluble semicarbazide sensitive amine oxidase (SSAO). Semicarbazide hydrochloride damages cartilage, blood vessels, ovaries, testicles, and thyroid follicles .
1
1 Cited Publications
Art. -Nr.: HY-A0070AG
CAS. Nr.: 6893-02-3
Synonyms: Triiodothyronine (GMP); 3,3',5-Triiodo-L-thyronine (GMP); T3 (GMP)
1
1 Cited Publications
Art. -Nr.: HY-W008859
CAS. Nr.: 67-30-1
Synonyms: Tetraiodothyroacetic acid; 3,3',5,5'-Tetraiodothyroacetic acid
Category:
Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite Disease Research Fields Cancer
Target:
1
1 Cited Publications
Art. -Nr.: HY-P7803
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PKM; Tumor M2-PK; Prev. PKM2; P58; THBP1; thyroid Hormone-Binding Protein, Cytosolic; OIP3; Epididymis Secretory Protein Li 30; PK3; Pyruvate Kinase Isozymes M1/M2; Pyruvate Kinase Muscle Isozyme; OPA-Interacting Protein 3; Cytosolic thyroid Hormone-Bindi
Species:
Human
Source:
E. coli
1
1 Cited Publications
Art. -Nr.: HY-W017113
CAS. Nr.: 149-30-4
1
1 Cited Publications
Art. -Nr.: HY-P99165
CAS. Nr.: 1036734-93-6
Target:
Forschungsgebiete:
1
Target:
Forschungsgebiete:
Crolibulin (EPC2407) is a tubulin polymerization inhibitor, with potent apoptosis induction and cell growth inhibition. Crolibulin has anti-tumor activity. Crolibulin also has cardiovascular toxicity and neurotoxicity .
1
Forschungsgebiete:
Mitiperstat (AZD4831) is an effective oral inhibitor of myeloperoxidase (MPO). Mitiperstat inhibits MPO and thyroid peroxidase (TPO) with IC50s of 1.5 nM and 0.69 μM. Mitiperstat exhibits a weak inhibitory activity against CYP3A4 with an IC50 of 6 μM. Mitiperstat can reduce inflammation and improve microvascular function, and it can be used in studies related to heart failure, preserved or mildly reduced ejection fraction, non-alcoholic fatty liver disease, and chronic obstructive pulmonary disease .
1
Forschungsgebiete:
KB130015 (KB015) is an orally active and potent ThRα and ThRβ (thyroid hormone receptor) inhibitor, with IC50 values of 4.5 and 5.1 μM, respectively. KB130015 markedly slows the kinetics of inactivation of Na + channels. KB130015 activates hERG1 channels (EC50 = 12.2 μM) and large-conductance Ca 2+-activated K + (BKCa) channels formed by hSlo1 (α) subunits in HEK 293 cells. KB130015 has antiarrhythmic properties. KB130015 can be used for the study of cardiovascular disease .
1
1 Cited Publications
Art. -Nr.: HY-P71917
Reinheit: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: P4HB; Protein Disulfide Isomerase Family A, Member 1; Prev. ERBA2L; Cellular thyroid Hormone-Binding Protein; Prev. PO4DB; Prolyl 4-Hydroxylase, Beta Polypeptide; PDIA1; Collagen Prolyl 4-Hydroxylase Beta; PDI; Procollagen-Proline, 2-Oxoglutarate 4-Dioxyg
Species:
Human
Source:
E. coli
1
1 Cited Publications
Synonyms: Telobufotoxin; Telocinobufogenin
Category:
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
