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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
63 Results for "
wee1
" in MedChemExpress (MCE) Product Catalog:
Products (63)
63 Results for "wee1" in MCE Product Catalog:
Cat. No.: HY-P701726
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: wee1; wee1 G2 Checkpoint Kinase; wee1-Like Protein Kinase; wee1A; wee1A Kinase; wee1hu; Non-Specific Protein-Tyrosine Kinase; wee1+ (S. Pombe) Homolog; wee1 Homolog (S. Pombe); Protein Kinase; wee1+ Homolog; wee1 Homolog
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701727
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: wee1; wee1 G2 Checkpoint Kinase; wee1-Like Protein Kinase; wee1A; wee1A Kinase; wee1hu; Non-Specific Protein-Tyrosine Kinase; wee1+ (S. Pombe) Homolog; wee1 Homolog (S. Pombe); Protein Kinase; wee1+ Homolog; wee1 Homolog
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705896
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: wee1; wee1 G2 Checkpoint Kinase; wee1-Like Protein Kinase; wee1A; wee1A Kinase; wee1hu; Non-Specific Protein-Tyrosine Kinase; wee1+ (S. Pombe) Homolog; wee1 Homolog (S. Pombe); Protein Kinase; wee1+ Homolog; wee1 Homolog
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-189307
Target:
Research Areas:
WEE1-IN-15 is an ATP-competitive, selective WEE1 kinase inhibitor (IC50: 42 nM). WEE1-IN-15 abolishes CDK1 phosphorylation. WEE1-IN-15 induces DNA damage and replication stress, and increases the S-phase cell population. WEE1-IN-15 shows selective anticancer effects on colorectal cancer organoids. WEE1-IN-15 can be used for research on colorectal cancer [1].
Cat. No.: HY-P706113
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: wee1; wee1 G2 Checkpoint Kinase; wee1-Like Protein Kinase; wee1A; wee1A Kinase; wee1hu; Non-Specific Protein-Tyrosine Kinase; wee1+ (S. Pombe) Homolog; wee1 Homolog (S. Pombe); Protein Kinase; wee1+ Homolog; wee1 Homolog
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-108343R
CAS No.: 622855-37-2
Target:
Research Areas:
WEE1-IN-4 (Standard) is the analytical standard of WEE1-IN-4 (HY-108343). This product is intended for research and analytical applications. WEE1-IN-4 (Compound 15) is a potent checkpoint Wee1 Kinase inhibitor with an IC50 of 0.011 μM. Wee1 inhibitors can abrogate the G2/M checkpoint [1].
Cat. No.: HY-183547
CAS No.: 3055032-68-0
WEE1/PKMYT1-IN-4 is a selective WEE1/PKMYT1 inhibitor, with IC50 values of 0.185 μM and 2.2 nM for human WEE1 and PKMYT1, respectively. WEE1/PKMYT1-IN-4 inhibits phosphorylation of CDK1 at T14 and Y15, disrupting the G2/M cell cycle checkpoint. WEE1/PKMYT1-IN-4 can be used for the research of colorectal cancer and amplified breast cancer [1].
Cat. No.: HY-13925A
CAS No.: 212391-63-4
PD0166285 dihydrochloride, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD0166285 dihydrochloride exhibits an IC50 of 3.433 μM for Chk1 [1].
Cat. No.: HY-P706186
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: wee1-like protein kinase; wee1A kinase
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P87147
Synonyms: DKFZp686I18166 antibody; EC 2.7.10.2 antibody; FLJ16446 antibody; MGC105683 antibody; OTTHUMP00000231338 antibody; OTTHUMP00000231339 antibody; wee 1 antibody; wee 1 homolog 1 (S. pombe) antibody; wee1 antibody; wee1 homolog (S. pombe) antibody; DKFZp686I18166 antibody; EC 2.7.10.2 antibody; FLJ16446 antibody; MGC105683 antibody; OTTHUMP00000231338 antibody; OTTHUMP00000231339 antibody; wee 1 antibody; wee 1 homolog 1 (S. pombe) antibody; wee1 antibody; wee1 homolog (S. pombe) antibody; wee1 homolog antibody; wee1 homolog S. pombe antibody; wee1 like protein kinase antibody; wee1 tyrosine kinase antibody; wee1+ homolog antibody; wee1+ S. pombe homolog antibody; wee1, S. pombe, homolog of antibody; wee1, somatic antibody; wee1-like protein kinase antibody; wee1_HUMAN antibody; wee1A antibody; wee1A kinase antibody; wee1hu antibody;
Cat. No.: HY-N0819R
CAS No.: 89412-79-3
Category:
Cat. No.: HY-P701729
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: wee2; wee2 Oocyte Meiosis Inhibiting Kinase; wee1B; wee1-Like Protein Kinase 1B; wee1-Like Protein Kinase 2; wee1B Kinase; wee1 Homolog 2; FLJ16107; wee1 Homolog 2 (S. Pombe); OZEMA5; OOMD5
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-187907
CAS No.: 3038330-83-2
Synonyms: SGR-3515
Surbinsertib (SGR-3515) is an orally active dual inhibitor of the Wee1 and Myt1 kinases. Surbinsertib is used in cancer research [1] .
Cat. No.: HY-208742
CAS No.: 2414418-56-5
Target:
PROTACs Wee1 Polo-like Kinase (PLK) Apoptosis Epigenetic Reader Domain Eukaryotic Initiation Factor (eIF) CDK
Research Areas:
ZNL-02-096 is a selective Wee1 PROTAC degrader. ZNL-02-096 binds to CRBN and Wee1 to form a ternary complex, inducing CRBN- and proteasome-dependent ubiquitination and proteasomal degradation of Wee1. ZNL-02-096 inhibits recombinant PLK1 with an IC50 of 102 nM, but does not induce its degradation in cells. ZNL-02-096 induces G2/M phase arrest, Apoptosis, transient integrated stress response, upregulation of ATF4, and phosphorylation of GCN2. ZNL-02-096 reduces Tyr15 phosphorylation of CDK1. ZNL-02-096 can be used in research related to ovarian cancer, acute lymphoblastic leukemia, triple-negative breast cancer, multiple myeloma, and pancreatic ductal adenocarcinoma [1] .
Cat. No.: HY-182433
CAS No.: 1847445-87-7
Target:
Research Areas:
CJM061 is a WEE1 kinase inhibitor with a target IC50 of 2.8 nM. CJM061 acts as a sensitizer and exhibits synergistic effects with Cisplatin (HY-17394) in medulloblastoma cells. CJM061 can be used for the research of medulloblastoma [1].
Cat. No.: HY-W1135319
Target:
Research Areas:
SB-405483 is a CRBN orthosteric ligand bindign enhancer. SB-405483 potentiates degradation of CRBN substrates including CK1α, Wee1, IKZF1/3. SB-405483 stabilizes CRBN and reduces CRBN autoubiquitination. SB-405483 can be used for the research of cancer, such as multiple myeloma and acute myeloid leukemia [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
