Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
59 Results for "
B-form dsDNA
" in MedChemExpress (MCE) Product Catalog:
Products (59)
59 Results for "B-form dsDNA" in MCE Product Catalog:
Category:
Cat. No.: HY-E70608
Target:
Research Areas:
PcrA spirase is an ATP-driven 3′ to 5′ helicase responsible for unwinding double-stranded DNA (dsDNA). PcrA spirase binds to dsDNA and unwinds it into two single-stranded DNAs (ssDNA).
Cat. No.: HY-E70607
Target:
Research Areas:
MutS protein, thermophilic bacteria is a DNA mismatch-binding protein that can be used to detect mismatched double-stranded DNA (dsDNA) .
Cat. No.: HY-D3374
CAS No.: 169454-15-3
Cat. No.: HY-D3404
CAS No.: 169454-13-1
Cat. No.: HY-D3414
CAS No.: 169454-17-5
Target:
Research Areas:
BODi-3 is an orange fluorescent dye. As a cell-impermeable nucleic acid stain, BODi-3 exhibits no fluorescence in the absence of nucleic acids, but shows multiple fluorescence enhancement upon binding to dsDNA. BODi-3 can be used for nucleus imaging, bacterial and sperm labeling, nucleic acid detection and amplification, and as a temperature sensor.
Cat. No.: HY-185129
Target:
Research Areas:
Headpiece is a short, covalently linked double-stranded DNA (dsDNA). It is designed as the starting point of DNA-Encoded Libraries (DELs) synthesis. In each chemical synthesis step, the compounds are encoded by enzymatically ligating the respective DNA tags to the Headpiece. Finally, a closing primer containing the distal primer-binding site for PCR amplification is added to complete the library synthesis/encoding.
Cat. No.: HY-165400
CAS No.: 143413-84-7
Cat. No.: HY-101879R
CAS No.: 65-61-2
Cat. No.: HY-E71081
Target:
Research Areas:
(E,E)-Germacrene B synthase (EC 4.2.3.71) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ( (E,E)-Germacrene-B-forming) .
Cat. No.: HY-P992101
CAS No.: 3057276-00-0
Synonyms: AUR-200
Target:
Research Areas:
Cat. No.: HY-114180R
CAS No.: 2262452-06-0
Synonyms: RU320521 (Standard)
Research Areas:
RU.521 (Standard) is the analytical standard of RU.521 (HY-114180). This product is intended for research and analytical applications. RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC50 of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS) .
Cat. No.: HY-E71107
Target:
Research Areas:
(S)-2-Hydroxy-acid oxidase (EC 1.1.3.15) is a flavoprotein (FMN) . Exists as two major isoenzymes; the A form preferentially oxidizes short-chain aliphatic hydroxy acids; the B form preferentially oxidizes long-chain and aromatic hydroxy acids.
Cat. No.: HY-147129
CAS No.: 2369750-66-1
Target:
Research Areas:
cGAS-IN-9 is a cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) inhibitor, with IC50 values of 27.5 nM and 5.15 μM against human and murine cGAS, respectively. cGAS-IN-9 shows weak inhibitory activity against human soluble adenylate cyclase, with an IC50 of 26.4 μM. cGAS-IN-9 inhibits dsDNA-induced expression of IFNB1 and CXCL10, as well as activation of the NF-κB pathway, in human immune cells. cGAS-IN-9 can be used in research related to cGAS-dependent inflammatory diseases .
Cat. No.: HY-184004
Research Areas:
NUCC-0231068 is a MNK1 and MNK2 inhibitor with IC50 values of 8 nM and 7 nM, respectively. NUCC-0231068 inhibits the phosphorylation of eukaryotic translation initiation factor 4E (eIF4E) at Ser209, with an IC50 of 23 nM in its purified form and 17 nM in its D2B form. NUCC-0231068 can be used in studies related to glioblastoma .
Cat. No.: HY-182769
CAS No.: 3066979-01-6
Target:
Research Areas:
TRβ agonist-4 is an orally bioavailable, liver-targeted selective agonist of hTHR-β (EC50=6.0 nM), with a 105.3-fold selectivity over THR-α. TRβ agonist-4 exists in multiple crystal forms, including Form A, Form B, Form C, Form D, Form E, as well as an amorphous form. TRβ agonist-4 can be used for research related to non-alcoholic steatohepatitis (NASH) .
Cat. No.: HY-181740
GCB-27b is an immunostimulant that binds to CD1d. GCB-27b forms a stable and long-lasting complex with CD1d, which is presented to the TCR of NKT cells to drive immune responses. GCB-27b induces a Th1-skewed immune response in *Mus musculus*, resulting in high expression of IFN?γ with restricted IL-4 levels. GCB-27b is applicable to research related to lung metastasis of melanoma .
Cat. No.: HY-189635
Target:
Research Areas:
NS3-IN-2 is a dual-target inhibitor targeting both NS2B‑NS3pro and NS3hel of West Nile virus (WNV). NS3-IN-2 inhibits the enzymatic activity of NS2B‑NS3pro toward polypeptide substrates in a non-competitive manner; for NS3hel, the compound exhibits a non-competitive inhibition mode with respect to ATP and competitive inhibition with respect to the dsDNA substrate. In biochemical assays, NS3-IN-2 has an IC50 = 4.4 μM against NS2B‑NS3pro and an IC50 = 24.0 μM against NS3hel helicase activity. NS3-IN-2 reduces WNV viral replication and exhibits cytotoxicity in hepatoma cells. NS3-IN-2 can be used for research on West Nile virus infection .
Cat. No.: HY-181085
Target:
Research Areas:
RD0448 is a potent inhibitor of DYRK1A, DYRK1B, and DYRK2. RD0448 selectively targets the non-native (folded intermediate) state of DYRK1A and DYRK1B. The binding site of RD0448 is hidden in the native state of DYRK1A and DYRK1B, and as a stabilizing binder, it binds tightly to both DYRK1A and DYRK1B, forming a stable complex with slow dissociation kinetics. In contrast, RD0448 targets the native state of DYRK2 without selectivity between its native and non-native states, acting as a weak binder with weaker binding affinity to DYRK2 and forming a rapidly dissociating complex .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
