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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
95 Results for "
PLK3 PBD
" in MedChemExpress (MCE) Product Catalog:
Products (95)
95 Results for "PLK3 PBD" in MCE Product Catalog:
Cat. No.: HY-176495
Research Areas:
SG3683 is a DNA-targeted cytotoxic agent belonging to pyrrolobenzodiazepine (PBD) dimers. SG3683 exerts antitumor activity with an IC50 value of 0.74 nM in MDA-MB-436 cells. SG3683 is promising for research of cancers, such as breast cancer .
Cat. No.: HY-15160A
CAS No.: 1137868-96-2
Target:
Research Areas:
TAK-960 hydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM. TAK-960 hydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. TAK-960 hydrochloride inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts .
Cat. No.: HY-10197R
CAS No.: 19545-26-7
Synonyms: SL-2052 (Standard); KY-12420 (Standard)
Cat. No.: HY-12137R
CAS No.: 755038-65-4
Synonyms: BI 6727 (Standard)
Research Areas:
Volasertib (Standard) is the analytical standard of Volasertib. This product is intended for research and analytical applications. Volasertib (BI 6727) is an orally active, highly potent and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with an IC50 of 0.87 nM. Volasertib inhibits PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively. Volasertib induces mitotic arrest and apoptosis. Volasertib, a dihydropteridinone derivative, shows marked antitumor activity in multiple cancer models .
Cat. No.: HY-172364
Target:
Research Areas:
PLK1-IN-12 is a highly selective and orally active PLK1 inhibitor with an IC50 of 20 nM. PLK1-IN-12 shows more selective for PLK1 than PLK2 (IC50: >10000 nM) and PLK3 (IC50: 3953 nM). PLK1-IN-12 exhibits anticancer potency across a broad spectrum of cell lines. PLK1-IN-12 can be used in anti-leukemia research .
Cat. No.: HY-173212
CAS No.: 3038489-48-1
Target:
Research Areas:
PLK1-IN-13 is a selective and orally active PLK1 inhibitor (IC50: 0.27 nM). PLK1-IN-13 also inhibits PLK2 (IC50: 12.72 nM) and PLK3 (IC50: 4.12 nM). PLK1-IN-13 arrests cell at G2 phase, induces apoptosis and down-regulates the transcription of the proliferation-related oncogene c-MYC. PLK1-IN-13 inhibits tumor growth, and can be used for research of acute myeloid leukemia (AML) .
Cat. No.: HY-126678
CAS No.: 3026416-27-0
Synonyms: Dimethyl-PBD dimer
Target:
Research Areas:
Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication .
Cat. No.: HY-164730
Synonyms: ADCT-602; hLL2-Cys-PBD
Target:
Research Areas:
Epratuzumab Tesirine (ADCT-602) is a novel CD22-targeted ADC. Epratuzumab Tesirine contains a PBD dimer and a payload SG3249 .
Cat. No.: HY-183965
Target:
Research Areas:
PLK3-IN-1 is a selective Polo-like kinase 3 (PLK3) inhibitor with a human PLK3 IC50 of 5 nM. PLK3-IN-1 can be used for cancer research .
Cat. No.: HY-128952G
CAS No.: 1595275-62-9
Synonyms: SG3249 (GMP)
Cat. No.: HY-15160C
CAS No.: 2108449-45-0
Target:
Research Areas:
TAK-960 monohydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM. TAK-960 monohydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. TAK-960 monohydrochloride inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts .
Cat. No.: HY-24144
CAS No.: 1430738-34-3
Target:
Research Areas:
Tesirine intermediate-2 is the intermediate of Tesirine (HY-128952). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.
Cat. No.: HY-47820
CAS No.: 1430738-05-8
Target:
Research Areas:
Tesirine intermediate-1 is the intermediate of Tesirine (HY-128952). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.
Cat. No.: HY-141599
CAS No.: 1853239-04-9
Synonyms: ADCT 301
Research Areas:
Cat. No.: HY-161521
CAS No.: 2991469-21-5
Target:
Research Areas:
PLK1-IN-10 (Compound 4Bb) is an orally active PLK1 PBD (polo-box domain) inhibitor. PLK1-IN-10 blocks the interaction of PLK1 with the cell division regulator protein 1 (PRC1) and decreases the protein expression of the CDK1-Cyclin B1 complex. PLK1-IN-10 reacts with glutathione (GSH) to increase cellular oxidative stress, ultimately leading to cell death .
Cat. No.: HY-129265
CAS No.: 321695-37-8
Target:
Research Areas:
Poloxin-2 is a small molecule Plk1 PBD inhibitor that can effectively induce cell mitotic arrest with an EC50 of approximately 15 μM in HeLa cells. Poloxin-2HT was developed by conjugating a hydrophobic tag (HT) to Poloxin-2, a new application of inhibitors targeting protein-protein interactions. Poloxin-2HT significantly enhanced the effects on cell viability and apoptosis by selectively degrading Plk1 protein, and its effect was stronger than that of untagged Poloxin-2. These data validate hydrophobic tags as a new strategy for targeting and disrupting disease-associated proteins.
Cat. No.: HY-138241
CAS No.: 148185-52-8
Target:
Research Areas:
PBD-BODIPY is a probe for the spectrophotometric measurement of autoxidation reactions. Co-autoxidation of the PBD-BODIPY signal carrier and a hydrocarbon co-substrate can be quantified by monitoring loss of absorbance at 591 nm. PBD-BODIPY has been used to measure the activity of radical-trapping antioxidants in cell-free assays. It has also been used as a fluorescent probe for the detection of epoxidation activity.
Cat. No.: HY-P702889
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PLK3; Proliferation-Related Kinase; Prev. CNK; Polo-Like Kinase 3; FNK; PLK-3; PRK; Polo-Like Kinase 3 (Drosophila); Cytokine-Inducible Serine/Threonine-Protein Kinase; Cytokine-Inducible Kinase; Serine/Threonine-Protein Kinase PLK3; Polo Like Kinase 3; F
Species:
Human
Source:
E. coli
Cat. No.: HY-P705596
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PLK3; Proliferation-Related Kinase; Prev. CNK; Polo-Like Kinase 3; FNK; PLK-3; PRK; Polo-Like Kinase 3 (Drosophila); Cytokine-Inducible Serine/Threonine-Protein Kinase; Cytokine-Inducible Kinase; Serine/Threonine-Protein Kinase PLK3; Polo Like Kinase 3; F
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P2289
Synonyms: PBD-1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
