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Cat. No.: HY-176495

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SG3683

SG3683 is a DNA-targeted cytotoxic agent belonging to pyrrolobenzodiazepine (PBD) dimers. SG3683 exerts antitumor activity with an IC₅₀ value of 0.74 nM in MDA-MB-436 cells. SG3683 is promising for research of cancers, such as breast cancer.

For research use only. We do not sell to patients.

Formula: C₆₂H₆₅N₇O₁₄
Molecular Weight:1132.22

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

SG3683 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

Chemical Information

Molecular Weight 1132.22
Formula C₆₂H₆₅N₇O₁₄
SMILES

O=C1C2=CC(OC)=C(OCC3=CC(COC4=C(C=C5C(N=C[C@@]6([H])N(C=C(C6)C)C5=O)=C4)OC)=CC(C#CCNC(CCOCCOCCOCCOCCNC(CC7=CC=C(N8C(C=CC8=O)=O)C=C7)=O)=O)=C3)C=C2N=C[C@@]9([H])N1C=C(C9)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li Q, et al. Improved Inhibition of Tumor Growth by Diabody-Drug Conjugates via Half-Life Extension. Bioconjug Chem. 2019 Apr 17;30(4):1232-1243. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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