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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
261 Results for "
microsomes
" in MedChemExpress (MCE) Product Catalog:
Products (261)
261 Results for "microsomes" in MCE Product Catalog:
Cat. No.: HY-CE01710
CAS No.: 87935-97-5
Synonyms: Coenzyme A,S-(9Z)-9-tetradecenoate
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Myristoleoyl-CoA (Coenzyme A,S-(9Z)-9-tetradecenoate) is a monounsaturated fatty acyl-CoA derivative. Myristoleoyl-CoA is produced via the Δ9-desaturase-catalyzed desaturation of myristoyl-CoA in chicken liver microsomes .
Cat. No.: HY-B0476S1
CAS No.: 72156-72-0
Cat. No.: HY-146084
CAS No.: 2476490-18-1
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PCSK9 modulator-3 is a PCSK9 modulator that reduces the secretion level of PCSK9 protein in HepG2 cells. PCSK9 modulator-3 exhibits metabolic stability in liver microsomes of mice and rats. PCSK9 modulator-3 can be used for the study of hyperlipidemia .
Cat. No.: HY-120398
CAS No.: 1253919-92-4
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CH5447240 is an agonist for parathyroid hormone receptor 1 (PTHR1), that inhibits human PTHR1 with an EC50 of 12 μM. CH5447240 exhibits good metabolic stability in human liver microsomes. CH5447240 increases serum calcium levels in rats. CH5447240 can be used in research about hypoparathyroidism .
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YM17E is an inhibitor of acyl CoA:cholesterol acyltransferase (ACAT), with IC50 of 44 nM in rabbit liver microsomes in vitro.
Cat. No.: HY-121345
CAS No.: 67910-07-0
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Cat. No.: HY-16718A
CAS No.: 1044535-61-6
Synonyms: PF-00251802 hydrochloride
Research Areas:
Dagrocorat (PF-00251802) hydrochloride is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat hydrochloride is also a time-dependent reversible inhibitor of CYP3A (IC50=1.3 μM in human liver microsomes) and CYP2D6 (Ki=0.57 μM in human liver microsomes). Dagrocorat hydrochloride can be used for the research of rheumatoid arthritis .
Cat. No.: HY-W154117
CAS No.: 16086-14-9
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2,2-Dichloro-1,1-ethanediol is a metabolite of the insecticides Dichlorvos (HY-B1312) and Trichlorphon, is mutagenic in the Salmonella/microsome test.
Cat. No.: HY-126665A
CAS No.: 1799421-49-0
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DMEA-PNU-159682 (molecule D12) dichloroacetate is an ADC cytotoxin molecule including metabolites of nemorubicin (MMDX) from liver microsomes and a potent ADCs cytotoxin PNU-159682 .
Cat. No.: HY-172565
Synonyms: SCH 56592 D-glucuronide
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Posaconazole D-glucuronide (SCH 56592 D-glucuronide) is a glucuronide metabolite of the antifungal agent Posaconazole (HY-17373). Posaconazole D-glucuronide can be formed in human liver microsomes catalyzed by UGT1A4 .
Cat. No.: HY-P10331
CAS No.: 2757292-12-7
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JG-23 is a 4-chloro modified analog with ability to promote t-tau degradation. JG-23 exhibits good metabolic stability with a long T1/2 value (36 min) in mouse liver microsome assays .
Cat. No.: HY-N13388
CAS No.: 27939-38-4
Synonyms: UGT1A6
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Cat. No.: HY-172147
CAS No.: 2761347-44-6
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SSTR4 agonist 5 (Compound 5) is the orally active agonist for somatostatin receptor 4 (SSTR4) with an EC50 of 0.228 nM. SSTR4 agonist 5 exhibits good stability in human/rat liver microsomes. SSTR4 agonist 5 inhibits mechanical hyperalgesia in rat models .
Cat. No.: HY-142931
CAS No.: 2662761-76-2
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ATM-IN-1 is a potent inhibitor of ATM. ATM is located mainly in the nucleus and microsomes and is involved in cell cycle progression and in the cell cycle checkpoint response to DNA damage. ATM-IN-1 has the potential for the research of cancer and neurology diseases (extracted from patent WO2021139814A1, compound 3) .
Cat. No.: HY-W741611
CAS No.: 67588-18-5
Synonyms: NSC 289346
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Dehydro warfarin is a metabolite of (±)-warfarin. It is formed from (±)-warfarin by rat liver microsomes.
Cat. No.: HY-134423
CAS No.: 193402-48-1
Synonyms: Stearoyl-CoA lithium
Cat. No.: HY-175078
CAS No.: 1350373-35-1
Synonyms: 19(20)-DHDP; (±)19,20-DiHDoPE
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(±)19(20)-DiHDPA is one of the major metabolites produces when docosahexaenoic acid is incubated with NADPH-supplemented rat liver microsomes .
Cat. No.: HY-113777
CAS No.: 90780-46-4
Synonyms: 22-Hydroxy Docosahexaenoic acid; 22-OH DHA
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22-HDHA (22-Hydroxy Docosahexaenoic acid) is an oxidation product of docosahexaenoic acid. In vitro, it is formed upon incubation of rat liver microsomes with DHA and NADPH and also by the human cytochrome P450 (CYP) isoform CYP4F3B in BTI-TN-5B1-4 microsomes. Serum levels of 22-HDHA increase following dietary DHA supplementation in humans.
Cat. No.: HY-16442
CAS No.: 160341-09-3
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S-3483, a Chlorogenic acid (HY-N0055) derivative, is a reversible, linear competitive glucose-6-phosphatase (Glc-6-Pase) system inhibitor. S-3483 inhibits Glc-6-Pase with a Ki 129 nM in rat liver microsomes. S-3483 specifically inhibits Glc-6-P transporter of renal and liver microsomes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
