1. GPCR/G Protein
    Metabolic Enzyme/Protease
  2. Glucocorticoid Receptor
    Cytochrome P450
  3. Dagrocorat hydrochloride

Dagrocorat hydrochloride (Synonyms: PF-00251802 hydrochloride)

Cat. No.: HY-16718A
Handling Instructions

Dagrocorat (PF-00251802) hydrochloride is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat hydrochloride is also a time-dependent reversible inhibitor of CYP3A (IC50=1.3 μM in human liver microsomes) and CYP2D6 (Ki=0.57 μM in human liver microsomes). Dagrocorat hydrochloride can be used for the research of rheumatoid arthritis.

For research use only. We do not sell to patients.

Dagrocorat hydrochloride Chemical Structure

Dagrocorat hydrochloride Chemical Structure

CAS No. : 1044535-61-6

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Description

Dagrocorat (PF-00251802) hydrochloride is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat hydrochloride is also a time-dependent reversible inhibitor of CYP3A (IC50=1.3 μM in human liver microsomes) and CYP2D6 (Ki=0.57 μM in human liver microsomes). Dagrocorat hydrochloride can be used for the research of rheumatoid arthritis[1].

IC50 & Target[1]

CYP3A

 

CYP2D6

 

In Vitro

Dagrocorat hydrochloride is metabolized by cytochrome P450 (CYP)3A to an N-oxide metabolite. Dagrocorat hydrochloride is a reversible inhibitor of several CYPs, such as CYP3A and CYP2D6[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

531.01

Formula

C₂₉H₃₀ClF₃N₂O₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Dagrocorat hydrochloride
Cat. No.:
HY-16718A
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