10028 Results for "

pyroglutamate modification

" in MedChemExpress (MCE) Product Catalog:
Products (10028)

10028 Results for "pyroglutamate modification" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-W342604
CAS No.: 5699-41-2
Synonyms: NAP
N-Acetylputrescine is a polyamine metabolite that regulates cell proliferation and signal transduction mainly by participating in polyamine acetylation modification. N-Acetylputrescine may reduce the positive charge of polyamines, affect protein-nucleic acid interactions, and promote cell growth. The concentration changes of N-Acetylputrescine can help disease diagnosis (such as early screening and efficacy evaluation of lung cancer) and microbial cell wall structure research. N-Acetylputrescine can be used as a potential biomarker for the progression of squamous cell carcinoma of the lung (SCCL) and Parkinson's disease (PD) .
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1
1 Cited Publications
Cat. No.: HY-B0515B
CAS No.: 138844-81-2
Target:  

Apoptosis

Research Areas:  

Metabolic Disease Cancer

Ibandronate Sodium is an orally active, selective inhibitor of farnesyl pyrophosphate synthase (FPP synthase). Ibandronate Sodium can block the mevalonate pathway to inhibit the isoprenylation modification of small GTPases (such as RAS, RHO family proteins), induce tumor cell apoptosis and inhibit bone resorption. Ibandronate Sodium inhibits tumor cell proliferation (such as ER+ breast cancer cells), promotes the expression of the pro-apoptotic gene FAS, and can produce synergistic anti-tumor effects with anti-estrogen compounds. Ibandronate Sodium is used in the study of osteoporosis and bone metastatic tumors (such as breast cancer bone metastasis) .
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Cat. No.: HY-P99859
CAS No.: 1931944-80-7
Synonyms: LY3002813

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Donanemab (LY3002813) is a humanized IgG1 monoclonal antibody directed at an N-terminal pyroglutamate amyloid beta (Aβ) epitope. Donanemab has the potential for early Alzheimer's disease research .
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Cat. No.: HY-101885
CAS No.: 109276-34-8
Purity:  99.76%
Synonyms: Biotinamidocaproyl hydrazide; BACH; (+)-Biotinamidohexanoic Acid hydrazide; Biotin Aminocaproyl Hydrazide
Biotin LC hydrazide is a long chain protein modification reagent, which can transform periodate-oxidized glycoproteins.
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Cat. No.: HY-140651
Purity:  ≥93.0%
Research Areas:  

Cancer

Amine-PEG2000-thiol is a conjugate containing amino, PEG and thiol groups, used for drug delivery, material modification and chemical synthesis.
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Cat. No.: HY-166990
CAS No.: 99126-64-4
Synonyms: MeO-PEG5000-Mal
Methoxypolyethylene glycol maleimide 5000 (MeO-PEG-Mal) can serve as a PEGylation reagent for bioconjugation, playing a role in protein modification and drug delivery systems .
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Cat. No.: HY-32290
CAS No.: 54571-66-3
Methyl DL-pyroglutamate is a kind of biochemical reagent.
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Cat. No.: HY-32291
CAS No.: 4931-66-2
Synonyms: (S)-Methyl 5-oxopyrrolidine-2-carboxylate; L-Pyroglutamic acid methyl ester
Target:  

NO Synthase

Research Areas:  

Infection Inflammation/Immunology

Methyl L-pyroglutamate ((S)-Methyl 5-oxopyrrolidine-2-carboxylate) is a phenolic compound. Methyl L-pyroglutamate can be isolated from Portulaca oleracea L. Methyl L-pyroglutamate slightly inhibits NO production. Methyl L-pyroglutamate can be used in the research of inflammatory diseases .
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Cat. No.: HY-148389
CAS No.: 68141-38-8
Synonyms: Sialylglycoasparaginate
Research Areas:  

Others

Disialo-Asn (Sialylglycoasparaginate) is an asparagine oligosaccharide. Disialo-Asn can be used for nucleic acid modification .
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Cat. No.: HY-167837
CAS No.: 27696-41-9
Synonyms: 8-Hydroxyluteolin
Hypolaetin (8-Hydroxyluteolin) is a flavone compound found in the bryophyte Marchantia berteroana, featuring diverse glycoside modifications .
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Cat. No.: HY-138246
CAS No.: 1807530-14-8
Purity:  99.50%
Research Areas:  

Others

Pentynoic acid STP ester sodium is a click chemistry reagent containing a terminal propargyl group and a STP ester group. Pentynoic acid STP ester sodium is suitable for protein modification .
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Cat. No.: HY-W013741
CAS No.: 2491-17-0
CME-carbodiimide is a nucleic acid modification reagent. CME-carbodiimide reacts specifically with uracil and guanine residues of RNA, as well as guanine and thymine residues of denatured DNA; it does not react with native DNA. Modification of DNA by CME-carbodiimide inhibits phosphodiester bond cleavage or DNA hydrolysis mediated by pancreatic ribonuclease, snake venom phosphodiesterase and deoxyribonuclease .
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Cat. No.: HY-118093
CAS No.: 4631-12-3
Purity:  99.89%
Target:  

Drug Metabolite

Research Areas:  

Others

N-benzoyl-L-aspartic acid, a major metabolite of benzyl glucosinolate, can be used for modification of peptides or proteins .
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Cat. No.: HY-19804
CAS No.: 1863117-91-2
Synonyms: Photo lysine
Photo-lysine, a new lysine-based photo-reactive amino acid, captures proteins that bind lysine post-translational modifications.
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Cat. No.: HY-P4885
CAS No.: 161818-04-8
Synonyms: AβpE3-40
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Glp-Amyloid-β (3-40) Peptide (human) (AβpE3-40) is a minor amounts of pyroglutamate-modified Aβ isolated from from 24-month-old Amyloid precursor protein (APP) transgenic Mice .
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Cat. No.: HY-W114327
CAS No.: 113886-71-8
Target:  

DNA/RNA Synthesis

Research Areas:  

Others

N4-Acetyl-2'-O-methylcytidine (ac4Cm) is an RNA with dual acetylation and methoxidation modifications found in thermophilic archaea. N4-Acetyl-2'-O-methylcytidine has been implicated in the adaptability of archaea in extreme environments, enhancing RNA stability through dual modification .
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Cat. No.: HY-131481
CAS No.: 32860-54-1
Mnm5s2U, found in lysine and glutamate tRNA anticodon, has an wobble modification function in tRNA .
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Cat. No.: HY-138603
CAS No.: 146954-77-0
Purity:  99.85%
5'-O-DMT-N4-Bz-2'-F-dC is a nucleoside with protective and modification effects.
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Cat. No.: HY-P3174
CAS No.: 9075-21-2
Target:  

Aminopeptidase

Research Areas:  

Inflammation/Immunology

Pyroglutamate aminopeptidase I is a type of enzyme that cleaves the peptide bond of pyroglutamic acid linked to the N-terminal end of a protein, including some important anti-inflammatory proteins like immunoglobulin .
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Inactive ASO (in vivo) sodium
0 Images
CCTATAGGACTATCCAGGAA
Cat. No.: HY-153734
Purity:  92.18%
Inactive ASO (in vivo) sodium is an inactive Antisense Oligonucleotide. ASO is a class of oligonucleotide molecules, usually composed of 20-30 bases, used to interfere with or regulate gene expression. Inactive ASO (in vivo) sodium is not targeted in the rodent genome and can be used as a negative control for Tofersen. Inactive ASO (in vivo) sodium contains thiophosphate skeleton modification and MOE modification. Cytosine in Inactive ASO (in vivo) is 5' methylcytosine. See References for the location of chemical modifications
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