CME-carbodiimide
Based on 1 Customer Validation
CME-carbodiimide is a nucleic acid modification reagent. CME-carbodiimide reacts specifically with uracil and guanine residues of RNA, as well as guanine and thymine residues of denatured DNA; it does not react with native DNA. Modification of DNA by CME-carbodiimide inhibits phosphodiester bond cleavage or DNA hydrolysis mediated by pancreatic ribonuclease, snake venom phosphodiesterase and deoxyribonuclease.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 2491-17-0
- Formula: C21H33N3O4S
- Molecular Weight:423.57
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
CME-carbodiimide (10 mg/mL; up to 40 h) binds preferentially to denatured calf-thymus DNA, binding 40 moles per 100 moles of nucleotide in heat-denatured samples, while binding minimally to native calf-thymus DNA and increasing amounts to ultraviolet-irradiated calf-thymus DNA in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2491-17-0
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Appearance Solid
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Molecular Weight 423.57
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Formula C21H33N3O4S
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Color White to off-white
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SMILES
C[N+]1(CCN=C=NC2CCCCC2)CCOCC1.O=S(C3=CC=C(C)C=C3)([O-])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
DMSO : 100 mg/mL (236.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3609 mL | 11.8044 mL | 23.6088 mL | 59.0221 mL |
| 5 mM | 0.4722 mL | 2.3609 mL | 4.7218 mL | 11.8044 mL | |
| 10 mM | 0.2361 mL | 1.1804 mL | 2.3609 mL | 5.9022 mL | |
| 15 mM | 0.1574 mL | 0.7870 mL | 1.5739 mL | 3.9348 mL | |
| 20 mM | 0.1180 mL | 0.5902 mL | 1.1804 mL | 2.9511 mL | |
| 25 mM | 0.0944 mL | 0.4722 mL | 0.9444 mL | 2.3609 mL | |
| 30 mM | 0.0787 mL | 0.3935 mL | 0.7870 mL | 1.9674 mL | |
| 40 mM | 0.0590 mL | 0.2951 mL | 0.5902 mL | 1.4756 mL | |
| 50 mM | 0.0472 mL | 0.2361 mL | 0.4722 mL | 1.1804 mL | |
| 60 mM | 0.0393 mL | 0.1967 mL | 0.3935 mL | 0.9837 mL | |
| 80 mM | 0.0295 mL | 0.1476 mL | 0.2951 mL | 0.7378 mL | |
| 100 mM | 0.0236 mL | 0.1180 mL | 0.2361 mL | 0.5902 mL |
CME-carbodiimide Related Classifications
HY-W013741 Related Classifications
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