496 Results for "

test

" in MedChemExpress (MCE) Product Catalog:
Products (496)

496 Results for "test" in MCE Product Catalog:

1
Dihexyl phthalate
Dihexyl phthalate
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1 Cited Publications
Cat. No.: HY-W011215
CAS No.: 84-75-3
Category:  

Natural Products Pyrus bretschneideri Rehder Rosaceae Plants

Target:  

Apoptosis Reactive Oxygen Species (ROS)

Dihexyl phthalate is an orally active phthalate ester (PAEs) widely used as a plasticizer, and it acts as an environmental endocrine disruptor. Dihexyl phthalate exhibits endocrine-disrupting and reproductive toxic properties, induces oxidative stress and inflammation, and ultimately causes apoptosis and damage to reproductive organs such as the testes. Dihexyl phthalate can be used in studies related to developmental toxicity, embryonic lethality, teratogenicity, and abnormal development of the male reproductive system .
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Artemitin
Artemitin
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1 Cited Publications
Cat. No.: HY-N3017
CAS No.: 479-90-3
Category:  

Flavonols other families Flavonoids Monophenols Phenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Antibiotic

Artemitin is a flavonoid neuroanesthetic agent with moderate cytotoxicity. Artemitint has selective inhibitory activity against Meth-A sarcoma cells with an ED50 of 5-10 μg/mL, and has no significant effect on LLC lung cancer cells. Artemitin exerts anticancer activity by affecting cell proliferation signaling pathways, and also has potential anti-inflammatory and neuroprotective effects. Artemitin exhibits a dose-dependent antinociceptive effect in the mouse hot plate test, with an ED50 of 1.6 μg/kg, and has analgesic activity .
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Amitifadine hydrochloride
Amitifadine hydrochloride
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1 Cited Publications
Cat. No.: HY-18332A
CAS No.: 410074-74-7
Synonyms: DOV-21947 hydrochloride; EB-1010 hydrochloride
Target:  

Serotonin Transporter Dopamine Transporter

Research Areas:  

Infection Neurological Disease

Amitifadine (DOV-21947; EB-1010) hydrochloride is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC50s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively.
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AMOZ
AMOZ
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1 Cited Publications
Cat. No.: HY-131146
CAS No.: 43056-63-9
Purity:  99.89%
Synonyms: 3-Amino-5-morpholinomethyl-2-oxazolidone
Target:  

Drug Metabolite

Research Areas:  

Infection

AMOZ is a carcinogenic metabolite of Furaltadone (HY-B1148A), which forms stable tissue residues by covalently binding to proteins as a hapten. AMOZ can be coupled with carrier proteins (such as BSA/OVA) to induce immune response and is released after acid hydrolysis. AMOZ residues can be detected by competitive ELISA method, and the detection limit in the monoclonal antibody 2E5.1 test is as low as 0.16 μg/kg (shrimp sample). AMOZ can be used as a typical marker to monitor drug residues in animal-derived foods in the field of food safety[1][2].
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Mambalgin 1 TFA
Mambalgin 1 TFA
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1 Cited Publications
Cat. No.: HY-P1441A
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC50 values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.
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TBHBA
TBHBA
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1 Cited Publications
Cat. No.: HY-15929
CAS No.: 14348-40-4
Synonyms: 2,4,6-Tribromo-3-hydroxybenzoic acid
TBHBA (2,4,6-Tribromo-3-hydroxybenzoic acid) is a chemical colorimetric agent and nanomaterial surface modifier. TBHBA can react with some oxidants (such as H2O2) to generate high-absorbance quinoneimine dyes, which enhance the sensitivity of HDL cholesterol enzymatic determination. TBHBA can be used as a bromine-containing coupling agent to modify the surface of silica nanoparticles through esterification reaction. Thereby, organic flame retardant groups are introduced to improve the thermal stability and flame retardant properties of nanocomposites. TBHBA can be used in clinical biochemical testing (such as serum lipoprotein analysis) and the preparation of flame-retardant polymer nanocomposites .
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Darutoside
Darutoside
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1 Cited Publications
Cat. No.: HY-N6028
CAS No.: 59219-65-7
Category:  

Terpenoids Diterpenoids Plants Compositae Disease Research Fields Tephrosia candida DC. Inflammation/Immunology

Target:  

COX NF-κB Interleukin Related TNF Receptor

Darutoside is an orally effective diterpene compound with significant anti-inflammatory, analgesic, wound healing promotion, and immunomodulatory activities. Darutoside reduces edema and pain responses by inhibiting the expression of COX-2 and the migration of inflammatory cells. It regulates macrophage polarization towards the M2 type by inhibiting the NF-κB pathway, alleviating inflammation and promoting wound healing. Through multi-target regulation of metabolic networks, Darutoside significantly alleviates acute gouty arthritis .
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Isotoosendanin
Isotoosendanin
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1 Cited Publications
Cat. No.: HY-N7694
CAS No.: 97871-44-8
Category:  

Triterpenes Terpenoids Melia toosendan Sieb. et Zucc. Plants Disease Research Fields Inflammation/Immunology Meliaceae

Target:  

TGF-β Receptor JAK STAT Apoptosis

Isotoosendanin is an orally active TGFβR1 inhibitor and abrogating its kinase activity (IC50 = 6732 nM). Isotoosendanin inhibits the JAK/STAT3 signaling pathway by directly targeting SHP-2, enhancing its stability, and reducing its ubiquitination. Isotoosendanin inhibits TGF-β-induced reduces the migration, invasion, and metastasis in triple-negative breast cancer (TNBC) cells. Isotoosendanin exhibits anti-tumor efficacy in TNBC xenograft models and A549 xenograft tumors. Isotoosendanin exhibits significant anti-inflammatory effects in acetic acid-induced vascular permeability and λ-carrageenan-induced hind paw edema tests. Isotoosendanin can be used for the study of non-small cell lung cancer (NSCLC), TNBC and inflammation .
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1,3,5-Trimethoxybenzene
1,3,5-Trimethoxybenzene
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1 Cited Publications
Cat. No.: HY-Y0678
CAS No.: 621-23-8
Synonyms: TRIMETHYL PHLOROGLUCINOL
Category:  

Natural Products Rosaceae Plants Rosa rugosa Thunb.

Target:  

Biochemical Assay Reagents

1,3,5-Trimethoxybenzene (TRIMETHYL PHLOROGLUCINOL) is an electrophilic substitution reaction substrate targeting free chlorine (Cl +) and free bromine (Br +). 1,3,5-Trimethoxybenzene has highly selective electrophilic addition characteristics. By capturing halogens, it undergoes specific substitution reactions to generate stable halogenated products. 1,3,5-Trimethoxybenzene can not only quench residual oxidants, but also quantify the halogen concentration by detecting the product without affecting the stability of redox-sensitive disinfection byproducts (DBPs). 1,3,5-Trimethoxybenzene is mainly used in water quality testing and quantitative analysis of free chlorine/bromine in water. At the same time, in phytochemistry, it is a key component of rose fragrance and participates in the study of pollination attraction mechanism .
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Chlorphenoxamine
Chlorphenoxamine
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1 Cited Publications
Cat. No.: HY-B1607
CAS No.: 77-38-3
Target:  

Histamine Receptor SARS-CoV Filovirus Parasite

Research Areas:  

Infection Neurological Disease Inflammation/Immunology

Chlorphenoxamine, an antihistamine and anticholinergic agent is a GPCR antagonist. Chlorphenoxamine inhibits multiple lethal viral diseases, such as SARS-CoV, MERS-CoV, EBOV and malaria. Chlorphenoxamine shows anti-filovirus activity against both EBOV and Marburg virus (MARV) with IC50s of 1.1 μM and 6.2 μM, respectively. Chlorphenoxamine is used for allergic conditions, urticaria, viral diseases and Parkinson’s disease .
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Xylenol orange tetrasodium salt, IND
Xylenol orange tetrasodium salt, IND
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1 Cited Publications
Cat. No.: HY-W110883
CAS No.: 3618-43-7
Xylenol orange tetrasodium salt, IND is commonly used as a colorimetric indicator for metal titration and possesses Zn 2+ chelating activity. Xylenol orange tetrasodium salt, IND binds Zn 2+ under physiological pH, and its Zn-XO complex allows visual differentiation between tartrate and malate ions. Xylenol orange tetrasodium salt, IND undergoes decolorization upon oxidation by hydrogen peroxide, undergoes a Co (II)-catalyzed pseudo-second-order reaction in a strong alkaline environment, and regulates the ferrous ion oxidation process mediated by peroxy radicals. Xylenol orange tetrasodium salt, IND forms colored ternary complexes with various anions, cations and iron-alanine, which is suitable for spectrophotometric quantification and can also be used for alanine irradiation dose detection. Xylenol orange tetrasodium salt, IND is applicable to EDTA metal titration analysis under acidic conditions .
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4,4'-Sulfonyldiphenol-d8
4,4'-Sulfonyldiphenol-d8
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1 Cited Publications
Cat. No.: HY-W011927S
CAS No.: 2483831-28-1
Synonyms: Bisphenol S (4,4'-Sulfonyldiphenol)-d8
4,4'-Sulfonyldiphenol-d8 (Bisphenol S (4,4'-Sulfonyldiphenol)-d8) is the deuterium labeled 4,4'-Sulfonyldiphenol (HY-W011927).4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC50 values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.
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Agar, microbiology tested, for cell culture (powder)
Agar, microbiology tested, for cell culture (powder)
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Cat. No.: HY-W134423
CAS No.: 9002-18-0
Agar, microbiology tested, for cell culture (powder) is a jelly like substance that contains agarose and agar gel. Agar, microbiology tested, for cell culture (powder) can be isolated from the cell walls of red algae species such as Gelidium and Gracilaria (Ogonori). The gelation and melting of Agar, microbiology tested, for cell culture (powder) is based on the hydrogen bridge (physical gels), so the gelation is reversible. Agar, microbiology tested, for cell culture (powder) is widely used in food additives, plant tissue culture, microorganisms culture media, fingerprint recognition, and medical fields .
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Deoxyribonucleic acid sodium salt from salmon testes
Deoxyribonucleic acid sodium salt from salmon testes
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Cat. No.: HY-172445
CAS No.: 438545-06-3
Synonyms: SS-DNA
Deoxyribonucleic acid sodium salt from salmon testes (SS-DNA) is a double-stranded deoxyribonucleic acid sodium salt extracted from salmon testes, which serves as an anti-adhesion agent and surface passivating agent for the surface of gold plasmonic sensors. Deoxyribonucleic acid sodium salt from salmon testes forms a nanoscale-thick film on the surface of gold plasmonic sensors, preventing non-specific adsorption of subsequent DNA analyte layers .
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Unifiram
Unifiram
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Cat. No.: HY-125931
CAS No.: 272786-64-8
Purity:  99.78%
Synonyms: DM232
Target:  

iGluR

Research Areas:  

Neurological Disease Inflammation/Immunology

Unifiram (DM232) is a AMPA receptor activator and cognitive enhancer. Unifiram activates the AMPA-mediated neurotransmission system. Unifiram reverses NBQX-induced amnesia in the passive avoidance test in mice. Unifiram reverses the antagonistic effect of kynurenic acid on NMDA-mediated [ 3H]NA release in rat hippocampal slices. Unifiram enhances excitatory synaptic transmission in the rat hippocampus in vitro. Unifiram can be used in studies related to amnesia and cognitive dysfunction, including age-related memory decline, neurodegenerative diseases such as Alzheimer's disease or Parkinson's disease, multiple sclerosis, schizophrenia, and attention deficit hyperactivity disorder .
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BES
BES
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Cat. No.: HY-D0867
CAS No.: 10191-18-1
BES is a secondary standard biochemical buffer with effective pH range of 6.4 to 7.8 (pKa: 7.15 at 20 °C). BES is used in the diagnostic testing area.
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L803-mts
L803-mts
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Cat. No.: HY-P1173
CAS No.: 706785-93-5
Synonyms: Myristoylated L 803; GSK-3β Inhibitor XIII
Target:  

GSK-3 Amyloid-β

Research Areas:  

Neurological Disease

L803-mts (Myristoylated L 803) is a selective and substrate-competitive GSK-3 peptide inhibitor (IC50: 40 μM). L803-mts also reduces Aβ deposits and ameliorates cognitive deficits in 5XFAD mice. L803-mts shows antidepressive effect in the forced swimming test .
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Z-Val-Val-Arg-AMC
Z-Val-Val-Arg-AMC
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Cat. No.: HY-137367
CAS No.: 124485-41-2
Purity:  99.77%
Target:  

Cathepsin

Research Areas:  

Infection

Z-Val-Val-Arg-AMC is a fluorescent peptide substrate that can be used to test the activity of cathepsins .
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HDAOS
HDAOS
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Cat. No.: HY-15918
CAS No.: 82692-88-4
HDAOS is a novel Trinder's reagent, which is a highly water-soluble aniline derivative. HDAOS is widely used in diagnostic tests and biochemical tests .
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Bentiromide
Bentiromide
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Cat. No.: HY-B1493
CAS No.: 37106-97-1
Target:  

Inhibitory Antibodies

Research Areas:  

Endocrinology

Bentiromide is a peptide that is broken down in the pancreas by chymotrypsin. The bentiromide test is an excellent means of confirming the diagnosis of pancreatic exocrine insufficiency by outpatient test of chymotrypsin function .
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