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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
760 Results for "
smooth
" in MedChemExpress (MCE) Product Catalog:
Products (760)
760 Results for "smooth" in MCE Product Catalog:
Cat. No.: HY-19261
CAS No.: 169042-78-8
Target:
Research Areas:
T-0632 is a CCK A receptor antagonist that exhibits significant pharmacological properties in in vitro studies. T-0632 competitively inhibits the binding of [125I]CCK-8 to rat pancreatic CCK A receptors with a K_i value of 0.24 nM, which is significantly lower than the K_i value for guinea pig CCK B receptors. T-0632 has higher selectivity in inhibiting CCK-8-stimulated pancreatic enzyme release, with an IC_50 value of 5.0 nM, which is more advantageous than L-364,718 and loxiglumide. In rabbit gallbladder smooth muscle, the antagonistic effects of T-0632 and loxiglumide are reversible, while L-364,718 shows a persistent inhibitory effect. These results indicate that T-0632 is a highly potent, reversible and more selective CCK A receptor antagonist.
Cat. No.: HY-B0380S1
CAS No.: 2747915-18-8
Cat. No.: HY-B0380S2
Target:
Potassium Channel Cholinesterase (ChE) TRP Channel NOD-like Receptor (NLR) Amyloid-β Tau Protein JNK NF-κB IKK
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
Drofenine (Cycloadiphene; Hexahydroadiphenine) is an brain-penetrant antispasmodic agent. Drofenine is a Kv2.1 channel inhibitor with human IC50 of 9.53 μM. Drofenine is a butyrylcholinesterase (BChE) inhibitor with Ki of 0.003 mM, and is a TRPV3 activator. Drofenine blocks Kv2.1-dependent potassium efflux, inhibits Kv2.1/JNK/NF-κB and IkBa/NF-kB signaling, suppresses Kv2.1 mRNA/protein expression. Drofenine suppresses oligomeric Aβ-induced microglial NLRP3 inflammasome activation and neuronal Tau hyperphosphorylation, improves cognitive impairment, promotes neurite outgrowth. Drofenine induces calcium influx in keratinocytes and exert cytotoxicity against keratinocytes. Drofenine ameliorates diabetic peripheral neuropathy -like pathology. Drofenine can be used for the researches of Alzheimer's disease, diabetic peripheral neuropathy and smooth muscle spasm .
Cat. No.: HY-P11642
CAS No.: 131748-26-0
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Cat. No.: HY-P2786A
CAS No.: 741738-57-8
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Cat. No.: HY-U00134R
CAS No.: 2179-37-5
Synonyms: Bencyclane (Standard); Benzcyclan (Standard)
Target:
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Benzcyclane (Standard) is the analytical standard of Benzcyclane (HY-U00134). This product is intended for research and analytical applications. Benzcyclane (Bencyclane; Benzcyclan) is a vasodilator with serotonin receptor antagonism. Benzcyclane exerts atypical serotonin antagonistic effects in rabbit superior mesenteric arteries. Benzcyclane relaxes high K +-induced contractions in rabbit basilar arteries and superior mesenteric arteries, and selectively inhibits sympathetic nerve stimulation-induced contractions in rabbit pulmonary arteries. Benzcyclane exerts non-competitive norepinephrine antagonistic effects in rabbit superior mesenteric arteries, and slightly reduces the maximum contractile response induced by histamine. Benzcyclane relaxes smooth muscles, induces transient hypotension, inhibits thrombosis, and accelerates blood fibrinolytic activity. Benzcyclane increases cerebral glucose content/uptake, enhances hypoxia tolerance in mice, and increases cerebral blood supply in dogs. Benzcyclane is applicable to studies related to cerebral vascular circulation .
Cat. No.: HY-W010476R
CAS No.: 14667-55-1
Category:
Cat. No.: HY-W010476S
CAS No.: 85735-49-5
Research Areas:
2,3,5-Trimethylpyrazine-d9 is the deuterated-labeled 2,3,5-Trimethylpyrazine (HY-W010476). 2,3,5-Trimethylpyrazine is an activator of OR5K1 with an EC50 of 65.03 μM in Hana-3A cells. 2,3,5-Trimethylpyrazine inhibits ZEN biosynthetic gene expression, disrupts cell membrane phospholipid composition, and inhibits mycelial growth. 2,3,5-Trimethylpyrazine inhibits DNA synthesis in the chorioallantoic membrane without disrupting vascular pattern formation. 2,3,5-Trimethylpyrazine inhibits ciliary beating frequency, oocyte pickup, and infundibular smooth muscle contraction in hamster oviduct explants. 2,3,5-Trimethylpyrazine is useful for research related to plant fungal infections .
Cat. No.: HY-W010476S1
CAS No.: 1082582-30-6
Research Areas:
2,3,5-Trimethylpyrazine-d3 is the deuterated-labeled 2,3,5-Trimethylpyrazine (HY-W010476). 2,3,5-Trimethylpyrazine is an activator of OR5K1 with an EC50 of 65.03 μM in Hana-3A cells. 2,3,5-Trimethylpyrazine inhibits ZEN biosynthetic gene expression, disrupts cell membrane phospholipid composition, and inhibits mycelial growth. 2,3,5-Trimethylpyrazine inhibits DNA synthesis in the chorioallantoic membrane without disrupting vascular pattern formation. 2,3,5-Trimethylpyrazine inhibits ciliary beating frequency, oocyte pickup, and infundibular smooth muscle contraction in hamster oviduct explants. 2,3,5-Trimethylpyrazine is useful for research related to plant fungal infections .
Cat. No.: HY-W100287R
CAS No.: 4532-33-6
Cat. No.: HY-W153159R
CAS No.: 13062-76-5
Cat. No.: HY-W153897R
CAS No.: 370-98-9
Cat. No.: HY-W276164
CAS No.: 1120-04-3
Synonyms: Sodium stearyl sulfate
Cat. No.: HY-W724350
Research Areas:
2,3,5-Trimethylpyrazine-d10 is the deuterated-labeled 2,3,5-Trimethylpyrazine (HY-W010476). 2,3,5-Trimethylpyrazine is an activator of OR5K1 with an EC50 of 65.03 μM in Hana-3A cells. 2,3,5-Trimethylpyrazine inhibits ZEN biosynthetic gene expression, disrupts cell membrane phospholipid composition, and inhibits mycelial growth. 2,3,5-Trimethylpyrazine inhibits DNA synthesis in the chorioallantoic membrane without disrupting vascular pattern formation. 2,3,5-Trimethylpyrazine inhibits ciliary beating frequency, oocyte pickup, and infundibular smooth muscle contraction in hamster oviduct explants. 2,3,5-Trimethylpyrazine is useful for research related to plant fungal infections .
Target:
Research Areas:
Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology
17-HDHA is a DHA-derived specialized pro-resolving mediator (SPM). 17-HDHA inhibits NF-κB activation by activating PPARγ and upregulating IκBα, targets FPR2 and Bcl-6, and also acts as a precursor of RvD1 and PD1. 17-HDHA inhibits pulmonary artery smooth muscle cell proliferation, regulates the expression of adiponectin, GLUT-4 and inflammatory cytokines, suppresses IgE production by B cells and promotes antibody secretion. 17-HDHA reduces adipose tissue inflammation, improves insulin sensitivity and glucose tolerance, alleviates pathological processes associated with pulmonary hypertension, and enhances antibody responses and virus neutralizing activity against influenza HA. 17-HDHA can be used in research related to obesity-associated inflammation, insulin resistance, glucose intolerance, pulmonary hypertension and influenza virus infection .
Cat. No.: HY-50723S1
Target:
Isotope-Labeled Compounds Endogenous Metabolite Phosphodiesterase (PDE) Caspase Bcl-2 Family Apoptosis
Research Areas:
3-Methylxanthine-d3 is deuterated labeled 3-Methylxanthine (HY-50723). 3-Methylxanthine is a blood-brain barrier-permeable cyclic GMP phosphodiesterase inhibitor, with an IC50 of 920 μM against guinea pig cyclic GMP phosphodiesterase. 3-Methylxanthine relaxes the spontaneous tension of isolated guinea pig tracheal smooth muscle preparations. Through a DRD1-dependent pathway, 3-Methylxanthine upregulates the expression of γH2AX and activated caspase-3, downregulates the expression of Bcl-2, and enhances Cisplatin-induced apoptosis (apoptosis) in ovarian cancer cells both in vitro and in vivo. 3-Methylxanthine induces clonic convulsions in the central nervous system. 3-Methylxanthine is the major metabolite of Theophylline (HY-B0809). 3-Methylxanthine can be used in studies related to ovarian cancer and neurotoxic convulsions .
Cat. No.: HY-B0380AR
CAS No.: 34140-59-5
Target:
Reference Standards Opioid Receptor Apoptosis Potassium Channel NF-κB Akt IRAK JNK Toll-like Receptor (TLR) ERK Calcium Channel
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Trimebutine maleate (Standard) is the analytical standard of Trimebutine maleate (HY-B0380A). This product is intended for research and analytical applications. Trimebutine maleate is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine maleate inhibits L-type Ca 2+ channels and large-conductance calcium-activated potassium channels (BKCa channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine maleate also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine maleate also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine maleate also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS) .
Cat. No.: HY-B0380R
CAS No.: 39133-31-8
Target:
Opioid Receptor Toll-like Receptor (TLR) Calcium Channel Potassium Channel IRAK ERK JNK NF-κB Akt Apoptosis Reference Standards
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Trimebutine (Standard) is the analytical standard of Trimebutine (HY-B0380). This product is intended for research and analytical applications. Trimebutine is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine inhibits L-type Ca 2+ channels and large-conductance calcium-activated potassium channels (BKCa channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
