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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
98 Results for "
Astrocyte
" in MedChemExpress (MCE) Product Catalog:
Products (98)
98 Results for "Astrocyte" in MCE Product Catalog:
Art. -Nr.: HY-14994R
CAS. Nr.: 1216720-69-2
Forschungsgebiete:
SCH79797 (dihydrochloride) (Standard) is the analytical standard of SCH79797 (dihydrochloride). This product is intended for research and analytical applications. SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 dihydrochloride inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 dihydrochloride also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes .
Art. -Nr.: HY-172586
CAS. Nr.: 1574354-24-7
Forschungsgebiete:
GSK-3α/β-IN-1 is GSK-3α/β inhibitor with IC50 s of 0.265 μM and 0.255 μM for GSK-3α and GSK-3β, respectively. GSK-3α/β-IN-1 also inhibits PKA with an IC50 of 0.188 μM. GSK-3α/β-IN-1 potently inhibits cell viability of three Glioblastoma (GBM) cell lines (IC50 : 3-6 μM, 72 h) with no toxicity to human astrocytes and good metabolic stability. GSK-3α/β-IN-1 has potential CNS activity in all-human blood-brain barrier (BBB) model of GBM .
Art. -Nr.: HY-P7605
Reinheit: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MANF; Arginine-Rich, Mutated In Early Stage Tumors; Prev. ARMET; Protein ARMET; ARP; DDDS; Mesencephalic Astrocyte-Derived Neurotrophic Factor; Mesencephalic Astrocyte Derived Neurotrophic Factor; Arginine-Rich Protein
Species:
Human
Source:
HEK293
Art. -Nr.: HY-P77296
Reinheit: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MANF; Arginine-Rich, Mutated In Early Stage Tumors; Prev. ARMET; Protein ARMET; ARP; DDDS; Mesencephalic Astrocyte-Derived Neurotrophic Factor; Mesencephalic Astrocyte Derived Neurotrophic Factor; Arginine-Rich Protein
Species:
Mouse
Source:
HEK293
Art. -Nr.: HY-P76731
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MANF; Arginine-Rich, Mutated In Early Stage Tumors; Prev. ARMET; Protein ARMET; ARP; DDDS; Mesencephalic Astrocyte-Derived Neurotrophic Factor; Mesencephalic Astrocyte Derived Neurotrophic Factor; Arginine-Rich Protein
Species:
Human
Source:
HEK293
Art. -Nr.: HY-101878R
CAS. Nr.: 60311-02-6
Synonyms: Sulforhodamine 101 (Standard); SR101 (Standard)
Art. -Nr.: HY-189217
CAS. Nr.: 3051563-45-9
Target:
Forschungsgebiete:
PARP7-IN-27 is a blood-brain barrier-permeable and selective PARP7 inhibitor with an IC50 of 22.8 nM. PARP7-IN-27 alleviates neuroinflammation and astrocyte activation, mitigates autophagy-related alterations, reduces the levels of ischemia-associated pro-inflammatory factors, and maintains the expression of synaptic markers. PARP7-IN-27 can be used in studies related to ischemic stroke .
Art. -Nr.: HY-183588
CAS. Nr.: 2117631-52-2
Target:
Forschungsgebiete:
HCM-01 is an Excitatory amino acid transporter 2 (EAAT2) activator with oral effectiveness and blood-brain barrier penetration.HCM-01 binds to the allosteric site of EAAT2, increases EAAT2 expression in astrocytes, enhances glutamate-handling capacity, and modulates glutamate homeostasis.HCM-01 acts as an antioxidant, improves oxidative/antioxidative balance and increases total antioxidant capacity. HCM-01 can be used for the research of Alzheimer's disease .
Art. -Nr.: HY-184919
CAS. Nr.: 3056058-96-6
Target:
Forschungsgebiete:
LMP2-IN-1 is an orally bioavailable, brain-permeable macrocyclic peptide epoxyketone, acts as a selective and irreversible inhibitor of LMP2 (IC50 = 87 nM). LMP2-IN-1 rapidly distributes to the brain and forms an irreversible LMP2:AR-01 adduct. LMP2-IN-1 improves memory function and rescues reactive astrocytes in 5xFAD mouse models of Alzheimer's disease (AD) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
