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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
98 Results for "
Astrocyte
" in MedChemExpress (MCE) Product Catalog:
Products (98)
98 Results for "Astrocyte" in MCE Product Catalog:
Cat. No.: HY-180899
CAS No.: 2249043-42-1
Target:
Research Areas:
CHI3L1-IN-5 (Compound Z17) is a highly selective CHI3L1 inhibitor with a KD value of 6 μM. CHI3L1-IN-5 restores the clearance ability of astrocytes by rejuvenating lysosomal function and Aβ uptake. CHI3L1-IN-5 alleviates neuroinflammation by inhibiting the NF-κB pathway. CHI3L1-IN-5 can be used for research on Alzheimer's disease .
Cat. No.: HY-E72101
Research Areas:
Human CYP2E1, Reductase+b5 refers to a near-physiological recombinant microsomal system co-expressed in insect cells, which consists of human cytochrome P450 2E1, NADPH-P450 oxidoreductase (CPR), and cytochrome b5. Human CYP2E1 is a human cytochrome P450 subtype belonging to the CYP2 family, and also a major oxidase. Its expression is centered in human liver, and can be induced in the brain (neurons, astrocytes, cerebellar granule cells), lung and kidney .
Cat. No.: HY-117710A
CAS No.: 1531586-58-9
Research Areas:
AD-35 free base is an orally active, blood-brain barrier-permeable acetylcholinesterase inhibitor with an IC50 of 793 nM. AD-35 free base inhibits metal-induced amyloid-β aggregation and disassembles preformed amyloid-β aggregates. In rat models of cognitive impairment, AD-35 free base attenuates Aβ25-35-induced astrocyte activation, TNF-α and IL-1β release, inhibits ERK phosphorylation, and alleviates learning and memory deficits. AD-35 free base can be used for research on Alzheimer's disease .
Cat. No.: HY-P7182A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GDNF; ATF2; Glial Cell Derived Neurotrophic Factor; ATF; Astrocyte-Derived Trophic Factor; Glial Cell Line Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor; Glial Derived Neurotrophic Factor; HFB1-GDNF; HSCR3; ATF1; HGDNF
Species:
Human
Source:
E. coli
Cat. No.: HY-180916
Research Areas:
CAII-IN-11 (Compound A1) is a dual-target compound that contains a hCA II inhibitor (IC₅₀ = 2 nM) portion and a NO donor portion. CAII-IN-11 also has inhibitory activity against hCA IX, hCA XII, and hCA I, with IC50 values of 6, 3, and 152 nM respectively. CAII-IN-11 significantly increases the intracellular cGMP level in human trabecular meshwork cells. CAII-IN-11 reduces the apoptosis of retinal ganglion cells by reducing oxidative stress (ROS levels), inhibiting astrocytes and the NLRP3 inflammasome activation. CAII-IN-11 has hypotensive activity in rabbit models and can be used for the study of glaucoma .
Cat. No.: HY-182899
Research Areas:
DPAP is a p-ERK1/2 inhibitor with an IC50 of 7.85 μM against p-ERK1/2. DPAP inhibits the expression of p-MEK1/2 and disrupts the Ras-ERK signaling pathway. DPAP inhibits the expression of COX-2 in nerve cells. DPAP damages DNA and mitochondria, induces Apoptosis via the mitochondrial pathway, and upregulates PD-L1. DPAP inhibits melanoma metastasis and angiogenesis, and inactivates spinal microglia and astrocytes. DPAP exhibits anti-melanoma activity and can be combined with anti-PD-1 monoclonal antibodies to modify anti-tumor effects. DPAP is applicable for the research of melanoma .
Cat. No.: HY-P73075
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GDNF; ATF2; Glial Cell Derived Neurotrophic Factor; ATF; Astrocyte-Derived Trophic Factor; Glial Cell Line Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor; Glial Derived Neurotrophic Factor; HFB1-GDNF; HSCR3; ATF1; HGDNF
Species:
Rat
Source:
Sf9 insect cells
Cat. No.: HY-P75169
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GDNF; ATF2; Glial Cell Derived Neurotrophic Factor; ATF; Astrocyte-Derived Trophic Factor; Glial Cell Line Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor; Glial Derived Neurotrophic Factor; HFB1-GDNF; HSCR3; ATF1; HGDNF
Species:
Canine
Source:
HEK293
Cat. No.: HY-P700084AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GDNF; ATF2; Glial Cell Derived Neurotrophic Factor; ATF; Astrocyte-Derived Trophic Factor; Glial Cell Line Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor; Glial Derived Neurotrophic Factor; HFB1-GDNF; HSCR3; ATF1; HGDNF
Species:
Human
Source:
E. coli
Cat. No.: HY-P700179AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GDNF; ATF2; Glial Cell Derived Neurotrophic Factor; ATF; Astrocyte-Derived Trophic Factor; Glial Cell Line Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor; Glial Derived Neurotrophic Factor; HFB1-GDNF; HSCR3; ATF1; HGDNF
Species:
Mouse
Source:
E. coli
Cat. No.: HY-182601
CAS No.: 1639784-02-3
Target:
Research Areas:
MC-100093 is an orally active, blood-brain barrier-permeable GLT-1 expression upregulator . MC-100093 upregulates the expression of GLT-1 and xCT in rats, and alleviates sedative agent-induced GLT-1 downregulation, IL-6 upregulation and motor hyperactivity. MC-100093 upregulates GLT-1 expression and enhances glutamate uptake in astrocyte-neuron co-culture systems. MC-100093 reduces ethanol consumption and preference, and exerts gender-specific antidepressant-like effects . MC-100093 can be used in studies related to sedative agent overdose, mood disorders and alcohol use disorders .
Cat. No.: HY-119590
CAS No.: 31501-55-0
Synonyms: Lonchocarpine
Cat. No.: HY-155949
CAS No.: 931305-29-2
Research Areas:
Bt354 is an orally active STAT3 inhibitor with IC50 values of 4.6 μM (DU145), 6.5 μM (MDA-MB-435) and 7.2 μM (MDA-MB-231), respectively. Bt354 induces cell cycle arrest and apoptosis, and downregulates epithelial-mesenchymal transition-related genes. Bt354 exhibits anti-angiogenic and anti-inflammatory activities, attenuates the polarization of M1 microglia and A1 astrocytes, suppresses inflammasome-related signaling pathways, and alleviates mechanical hyperalgesia and thermal hyperalgesia. Bt354 can be used in research related to glioblastoma multiforme, triple-negative breast cancer, prostate cancer and neuropathic pain .
Cat. No.: HY-N21694
CAS No.: 303084-57-3
Cat. No.: HY-P704369
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GDNF; ATF2; Glial Cell Derived Neurotrophic Factor; ATF; Astrocyte-Derived Trophic Factor; Glial Cell Line Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor; Glial Derived Neurotrophic Factor; HFB1-GDNF; HSCR3; ATF1; HGDNF
Species:
Human
Source:
HEK293
Cat. No.: HY-183352
CAS No.: 3067571-93-8
Target:
Cholinesterase (ChE) Toll-like Receptor (TLR) p38 MAPK Interleukin Related Complement System
Research Areas:
BuChE-IN-23 is an orally active, blood-brain barrier permeable butyrylcholinesterase (eqBuChE) inhibitor with an IC50 of 15.59 μM and a Ki of 29.33 μM. BuChE-IN-23 exhibits an IC50 of 38.65 μM against hBuChE and shows selectivity for butyrylcholinesterase over acetylcholinesterase. BuChE-IN-23 inhibits LPS (HY-D1056)-induced nitric oxide production, attenuates hippocampal glial cell activation and neuroinflammation, suppresses the TLR4/p38 MAPK signaling pathway, and regulates the IL-1β/C3-mediated microglia-astrocyte inflammatory axis. BuChE-IN-23 can be used for the research of Alzheimer's disease .
Cat. No.: HY-N21887
CAS No.: 105214-48-0
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
