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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
70 Results for "
GLI
" in MedChemExpress (MCE) Product Catalog:
Products (70)
70 Results for "GLI" in MCE Product Catalog:
Cat. No.: HY-182641
CAS No.: 1401532-77-1
Synonyms: SAG-Cl (cis-isomer)
Target:
Research Areas:
SAG analog (cis-isomer) (SAG-Cl (cis-isomer)) (Compound 10b) is a Gli1 activator with an EC50 of 7.6 nM. SAG analog (cis-isomer) is non-toxic .
Cat. No.: HY-N9684
CAS No.: 39941-51-0
Cat. No.: HY-182721
CAS No.: 2380013-55-6
Pipinib is an ATP-competitive and selective phosphatidylinositol 4-kinase IIIb (PI4KB) inhibitor with an IC50 of 2.2 μM. Pipinib reduces intracellular PI4P levels. Pipinib inhibits GLI-mediated transcription, the expression of Hedgehog target genes, and blocks the trafficking of Smoothened to cilia. Pipinib can be used in the research of basal cell carcinoma and medulloblastoma .
Cat. No.: HY-W338819
CAS No.: 25122-41-2
Target:
Research Areas:
Clobetasol is a glucocorticoid and Smoothened agonist that can cross the blood-brain barrier. Clobetasol induces Smo-dependent activation of the Shh signaling pathway and nuclear translocation of Gli1. Clobetasol promotes remyelination and reduces myelin loss in lesions of neuromyelitis optica (NMO). Clobetasol may cause adrenal suppression, cushingoid appearance, and local adverse reactions including dysgeusia, xerostomia, and gastroesophageal burning. Clobetasol can be used in research related to neurodegenerative diseases, oral lichen planus, mucous membrane pemphigoid, and neuromyelitis optica .
Cat. No.: HY-L038
2,574 compounds
Stem cells, which are found in all multi-cellular organisms, can divide and differentiate into diverse special cell types and can self-renew to produce more stem cells. To be useful in therapy, stem cells must be converted into desired cell types as necessary which is called induced differentiation or directed differentiation. Understanding and using signaling pathways for differentiation is an important method in successful regenerative medicine. Small molecules or growth factors induce the conversion of stem cells into appropriate progenitor cells, which will later give rise to the desired cell type. There is a variety of signal molecules and molecular families that may affect the establishment of germ layers in vivo, such as fibroblast growth factors (FGFs); the wnt family or superfamily of transforming growth factors β (TGFβ) and bone morphogenetic proteins (BMP). Unfortunately, for now, a high cost of recombinant factors is likely to limit their use on a larger scale in medicine. The more promising technique focuses on the use of small molecules. These small molecules can be used for either activating or deactivating specific signaling pathways. They enhance reprogramming efficiency by creating cells that are compatible with the desired type of tissue. It is a cheaper and non-immunogenic method.
MCE Differentiation Inducing Compound Library contains a unique collection of 2,574 compounds that act on signaling pathways for differentiation. These compounds are potential stimulators for induced differentiation. This library is a useful tool for researching directed differentiation and regenerative medicine.
Cat. No.: HY-P76364
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GLIPR1; GLIPR 1; GLI Pathogenesis Related 1; CDNA FLJ50386, Highly Similar To GLIoma Pathogenesis-Related Protein 1; RTVP1; Related To Testis-Specific, Vespid, And Pathogenesis Proteins 1; GLIPR; Testes-Specific Vespid And Pathogenesis Protein 1; GLIoma P
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P70359
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GLIPR1; GLIPR 1; GLI Pathogenesis Related 1; CDNA FLJ50386, Highly Similar To GLIoma Pathogenesis-Related Protein 1; RTVP1; Related To Testis-Specific, Vespid, And Pathogenesis Proteins 1; GLIPR; Testes-Specific Vespid And Pathogenesis Protein 1; GLIoma P
Species:
Human
Source:
HEK293
Cat. No.: HY-L020
654 compounds
The developmental proteins Hedgehog, Notch and Wnt are key regulators of cell fate, proliferation, migration and differentiation in several tissues. Their related signaling pathways are frequently activated in tumors, and particularly in the rare subpopulation of cancer stem cells. The Wnt signaling pathway is a conserved pathway in animals. Deregulated Wnt signaling has catastrophic consequences for the developing embryo and it is now well appreciated that defective Wnt signaling is a causative factor for a number of pleiotropic human pathologies, including cancer. Hedgehog signaling pathway is linked to tumorigenesis and is aberrantly activated in a variety of cancers. The Notch signaling pathway is a highly conserved cell signaling system present in most animals. It plays an important role in cell-cell communication, and further regulates embryonic development.
MCE designs a unique collection of 654 Wnt/Hedgehog/Notch signaling pathway-related small molecules. Wnt/Hedgehog/Notch Compound Library serves as a useful tool for stem cell research and anti-cancer drug screening.
Cat. No.: HY-P703488
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ZBTB48; Telomeric Zinc Finger-Associated Protein; Prev. HKR3; Krueppel-Related Zinc Finger Protein 3; ZNF855; GLI-Kruppel Family Member HKR3; TZAP; Zinc Finger Protein 855; Telomere-Binding Protein And Transcriptional Activator ZBTB48; Pp9964; Zinc Finger And BTB Domain-Containing Protein 48; Zinc Finger And BTB Domain Containing 48; Telomere Zinc Finger-Associated Protein; ZBTB48; Telomeric Zinc Finger-Associated Protein; Prev. HKR3; Krueppel-Related Zinc Finger Protein 3; ZNF855; GLI-Kruppel Family Member HKR3; TZAP; Zinc Finger Protein 855; Telomere-Binding Protein And Transcriptional Activator ZBTB48; Pp9964; Zinc Finger And BTB Domain-Containing Protein 48; Zinc Finger And BTB Domain Containing 48; Telomere Zinc Finger-Associated Protein
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
