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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
87 Results for "
fragmentation
" in MedChemExpress (MCE) Product Catalog:
Products (87)
87 Results for "fragmentation" in MCE Product Catalog:
Cat. No.: HY-168164
CAS No.: 53484-50-7
Target:
Research Areas:
4-Methoxycinnamyl alcohol is an anticancer compound with cytotoxic activity against MCF-7, HeLa, and DU145 cancer cell lines with IC50 values of 14.24, 7.82, and 22.10 μg/mL, respectively. 4-Methoxycinnamyl alcohol showed the ability to induce cell necrosis, rather than apoptosis, after a 48-hour DNA fragmentation assay. 4-Methoxycinnamyl alcohol was isolated from Foeniculum vulgare .
Cat. No.: HY-168720
Apoptosis inducer 32 (Compound 7g) is an apoptosis inducer with a KD of 42 μM, showing anti-tumor activity. Apoptosis inducer 32 caused significant cellular morphological changes in MDA-MB-231 cells, including membrane bubbling, nuclear fragmentation, and apoptotic body formation. The IC50 of Apoptosis inducer 32 in MCF-7, MDA-MB-231, and HEK cells is 4.77, 6.56 and 337.8 μM respectively .
Cat. No.: HY-A0170R
CAS No.: 147059-72-1
Research Areas:
Trovafloxacin (Standard) is the analytical standard of Trovafloxacin. This product is intended for research and analytical applications. Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current. Trovafloxacin does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1 .
Cat. No.: HY-138111
CAS No.: 129411-62-7
Synonyms: p-Nitopheyl β-D-cellotetaoside
Cat. No.: HY-N8617
CAS No.: 135247-94-8
Cat. No.: HY-116692
CAS No.: 582314-48-5
Apoptosis inducer 34 (Compound 4) is a small molecule compound that induces apoptosis by directly activating the intrinsic apoptotic pathway. Apoptosis inducer 34 promotes Apaf-1 oligomerization to form mature apoptosomes, thereby activating caspase-9 and caspase-3. It significantly activates the apoptotic pathway in Jurkat cells by enhancing the cytochrome c-dependent apoptotic signaling pathway, inducing PARP cleavage and chromosomal DNA fragmentation. Furthermore, Apoptosis inducer 34 exhibits low toxicity to normal cells, demonstrating potential for selective targeting of cancer cells. Apoptosis inducer 34 is a promising candidate for studying cancer related to apoptotic pathways .
Cat. No.: HY-N3055
CAS No.: 31685-80-0
Cat. No.: HY-149523
Target:
Research Areas:
Anticancer agent 157 (compound 15) is a NO inhibitor (IC50=0.62 μg/mL) with anti-inflammatory and anticancer activities. Anticancer agent 157 can bind to iNOS (inducible NO synthase) and caspase 8, causing nuclear fragmentation and chromatin condensation, inducing apoptosis. Anticancer agent 157 inhibits HT29 colon cancer cells (IC50=2.45 μg/mL), Hep-G2 liver cancer cells (IC50=3.25 μg/mL), and B16-F10 murine melanoma cells (IC50=3.84 μg/mL) .
Cat. No.: HY-W271506
CAS No.: 10135-38-3
Synonyms: 3,3,5,5-Tetramethyl-1-pyrroline 1-oxide
Research Areas:
TMPO (3,3,5,5-Tetramethyl-1-pyrroline 1-oxide) is a spin trap targeting free radicals. TMPO is capable of scavenging superoxide, hydroxyl radicals and inhibits thymocyte apoptosis with EC50 values of 19.1 mM (MPS-induced) to 30.7 mM (Etoposide-induced) for inhibiting DNA fragmentation. TMPO reacts with intracellular free radicals to form stable nitroxide radical products, reducing oxidative stress (e.g., decreasing peroxide levels, maintaining glutathione content) and blocking oxidative events in the apoptotic pathway. TMPO is promising for research of apoptosis in immune cells like thymocytes .
Cat. No.: HY-W777393
CAS No.: 1189992-05-9
Synonyms: 7-Hydroxycoumarin-13C6; Hydrangin-13C6; NSC 19790-13C6
Cat. No.: HY-P700499
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DFFA; DNA fragmentation Factor, 45kDa, Alpha Polypeptide; DNA fragmentation Factor Subunit Alpha; DNA fragmentation Factor 45 KDa Subunit; DFF-45; Inhibitor Of CAD; DFF45; DNA fragmentation Factor, 45 KD, Alpha Polypeptide; ICAD; DNA fragmentation Factor,
Species:
Human
Source:
E. coli
Cat. No.: HY-P7814
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DFFA; DNA fragmentation Factor, 45kDa, Alpha Polypeptide; DNA fragmentation Factor Subunit Alpha; DNA fragmentation Factor 45 KDa Subunit; DFF-45; Inhibitor Of CAD; DFF45; DNA fragmentation Factor, 45 KD, Alpha Polypeptide; ICAD; DNA fragmentation Factor,
Species:
Human
Source:
E. coli
Cat. No.: HY-162397
Category:
Target:
Cat. No.: HY-169795
CAS No.: 175892-43-0
C8 D-threo Ceramide (d18:1/8:0) is a sphingolipid analog that can effectively induce apoptosis in U937 cells and cause fragmentation of nucleosomal DNA .
Cat. No.: HY-126473
CAS No.: 70010-76-3
Research Areas:
NE97220 is a biochemical reagent. NE97220 induces macrophage apoptosis and reduces their viability, leading to internucleosomal DNA fragmentation. NE97220 inhibits the growth of Trypanosoma brucei rhodesiense . NE97220 is used in research on human African trypanosomiasis and immune-related studies .
Cat. No.: HY-W714212
CAS No.: 33245-39-5
Research Areas:
Fluchloralin is a dinitroaniline herbicide that effectively controls annual gramineous and broadleaf weeds primarily by inhibiting tubulin synthesis and cell division . Fluchloralin exhibits cytotoxicity and genotoxicity, and promotes cell apoptosis by activating apoptotic signaling proteins, forming DNA ladder bands, inducing cell shrinkage and nuclear fragmentation .
Cat. No.: HY-117208
CAS No.: 748786-57-4
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TLSC702 is a human glyoxalase I (hGLO I) inhibitor with an IC50 of 2.0 μM. TLSC702 inhibits the activity of human glyoxalase I, thereby leading to the accumulation of methylglyoxal and its derived advanced glycation end products. TLSC702 inhibits tumor cell proliferation, induces apoptotic morphological changes, internucleosomal DNA fragmentation and PARP cleavage in tumor cells. TLSC702 can be used in research related to leukemia and lung cancer .
Cat. No.: HY-183877
CAS No.: 288254-44-4
Research Areas:
YO-2 is a plasmin inhibitor and TP53 upregulator with anti-tumor and apoptosis-inducing activities. YO-2 upregulates the expression of TP53 and the tumor-suppressive miR-103/107, downregulates LRP1, and induces cellular DNA fragmentation and caspase cascade activation. YO-2 effectively blocks the growth of melanoma. YO-2 has been widely used in studies related to melanoma and colon cancer .
Cat. No.: HY-P1380
CAS No.: 396834-58-5
Target:
Research Areas:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
