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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
108 Results for "
NEK
" in MedChemExpress (MCE) Product Catalog:
Products (108)
108 Results for "NEK" in MCE Product Catalog:
Cat. No.: HY-136747
CAS No.: 560103-80-2
Synonyms: Nec2/Hec1 inhibitor
Target:
Research Areas:
N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide is a derivative of INH1 with anticancer activity. It is cytotoxic to MDA-MB-231, MDA-MB-488, HeLa, and K562 cells (IC50s=1.1, 3.4, 1.6, and 1.2 μM, respectively).
Cat. No.: HY-N0373R
CAS No.: 58749-23-8
Cat. No.: HY-208735
CAS No.: 3120512-57-1
Target:
Research Areas:
NEK7 degrader-5 is a NEK7 degrader. NEK7 degrader-5 inhibits the release of proinflammatory cytokines IL-1β and IL-18. NEK7 degrader-5 can be used for the research of inflammatory and tumor diseases .
Cat. No.: HY-185311
CAS No.: 3119435-52-5
Research Areas:
NEK7 degrader-3 is an orally active and brain-penetrant NEK7 molecular glue degrader with a DC50 of 33.1 nM. NEK7 degrader-3 mediates interaction between NEK7 and E3 ligase cereblon, promoting proteasomal degradation of NEK7 and attenuating NLRP3 inflammasome-mediated inflammatory responses. NEK7 degrader-3 inhibits caspase-1 activity, cytokine release of IL-1β, IL-1α, and IL-18, and pyroptosis-related plasma membrane permeabilization. NEK7 degrader-3 shows antiinflammatory activity in an LPS (HY-D1056)-induced neuroinflammation mouse model. NEK7 degrader-3 can be used for the research of neuroinflammation .
Cat. No.: HY-RS17220
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Nek7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nek7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17589
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Nek6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nek6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS21388
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Nek8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nek8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS21389
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Nek9 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nek9 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24049
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Nek6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nek6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS26814
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Nek3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nek3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS27907
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Research Areas:
Nek8 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nek8 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P702740
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: NEK7; Never In Mitosis A-Related Kinase 7; NIMA Related Kinase 7; NimA-Related Protein Kinase 7; NIMA (Never In Mitosis Gene A)-Related Kinase 7; NEK6-Subfamily Protein Kinase; Serine/Threonine-Protein Kinase NEK7
Species:
Human
Source:
E. coli
Cat. No.: HY-P701253
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NEK7; Never In Mitosis A-Related Kinase 7; NIMA Related Kinase 7; NimA-Related Protein Kinase 7; NIMA (Never In Mitosis Gene A)-Related Kinase 7; NEK6-Subfamily Protein Kinase; Serine/Threonine-Protein Kinase NEK7
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
