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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
108 Results for "
PL
" in MedChemExpress (MCE) Product Catalog:
Products (108)
108 Results for "PL" in MCE Product Catalog:
Cat. No.: HY-150786
PLP_Snyder530 is a potent papain-like protease (PL pro) inhibitor with an IC50 value of 6.4 μM. PLP_Snyder530 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. PLP_Snyder530 can be used for SARS-CoV-2 research .
Cat. No.: HY-150783
SARS-CoV-2-IN-24 (compound 7) is a potent papain-like protease (PL pro) inhibitor. SARS-CoV-2-IN-24 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. SARS-CoV-2-IN-24 can be used for SARS-CoV-2 research .
Cat. No.: HY-152589
CAS No.: 2761367-25-1
Antiviral agent 25 (compound 6g) is a new non-peptide analog covalent inhibitor of SARS-CoV-2 3CL pro. Antiviral agent 25 has a strong inhibitory effect on SARS-CoV-2 3CL pro and SARS-CoV-2 PL pro with IC50 values of 0.118 µM, 0.448 µM, respectively. Antiviral agent 25 has antiviral effect on SARS-CoV-2 with an EC50 value of 7.249 µM .
Cat. No.: HY-182718
CAS No.: 2374807-39-1
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AZD0011-PL is a human arginase 1/ 2 inhibitor with IC50 values of 0.01 μM and 0.02 μM. AZD0011-PL can be used for the researches of cancer, respiratory inflammatory disease .
Cat. No.: HY-124655
CAS No.: 1897406-94-8
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S1PL-IN-2 (Compound 28) is a potent sphingosine-1-phosphate lyase (S1PL) inhibitor with an IC50 of 120 nM. S1PL-IN-2 shows an IC50 of 230 nM on HEK293 cells. S1PL-IN-2 block the conversion of Vitamin B6 into the active pyridoxal-4-phosphate cofactor required for S1P lyase activity. S1PL-IN-2 can be used for the researches of inflammation and immunology, such as rheumatoid arthritis .
Cat. No.: HY-P992291
Cat. No.: HY-P10838A
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Cat. No.: HY-115851
CAS No.: 1206514-62-6
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Demethyl PL265 is an enduring dual ENKephalinase inhibitor (DENKi) that holds promise for pain relief.
Cat. No.: HY-183860
CAS No.: 2131171-67-8
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Pefabloc PL is a plasmin inhibitor with submicromolar-range inhibitory activity against the trypsin-like serine protease plasmin .
Cat. No.: HY-P77147
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CSH1; Chorionic Somatomammotropin Hormone 1 Isoform 1; Chorionic Somatomammotropin Hormone 1; Chorionic Somatomammotropin-1; PL; HCG1749481, Isoform CRA_k; PLacental Lactogen; HCG1749481, Isoform CRA_i; Choriomammotropin; HCG1749481, Isoform CRA_e; HCS-A
Species:
Human
Source:
HEK293
Cat. No.: HY-P7871
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CSH1; Chorionic Somatomammotropin Hormone 1 Isoform 1; Chorionic Somatomammotropin Hormone 1; Chorionic Somatomammotropin-1; PL; HCG1749481, Isoform CRA_k; PLacental Lactogen; HCG1749481, Isoform CRA_i; Choriomammotropin; HCG1749481, Isoform CRA_e; HCS-A
Species:
Human
Source:
HEK293
Cat. No.: HY-P81503A
Synonyms: Pancreatic lipase; PL; PNLIP; PNLIPD; PTL
Cat. No.: HY-RS17771
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Pnlip Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pnlip gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-182719
CAS No.: 2374807-41-5
AZD0011, a prodrug of AZD0011-PL (HY-182718), is an orally active arginase 1 inhibitor with an IC50 of 328 nM. AZD0011 undergoes in vivo hydrolysis to release an arginase inhibitor payload, inhibiting arginine hydrolysis, increases arginine levels in plasma and the tumor microenvironment. AZD0011 restores innate immune function and inhibits tumor growth. AZD0011 can be used for the research of cancer, such as fibrosarcoma .
Cat. No.: HY-181661
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YL1004 is a potent, selective and orally active noncovalent inhibitor of SARS-CoV-2 papain-like protease (PL pro). YL1004 shows an IC50 of 17.5 nM and a Ki of 2.3 nM against PL pro, with an in vitro anti-SARS-CoV-2 EC50 of 0.08 μM-1.37 μM. YL1004 suppresses the proteolytic activity of PL pro and blocks its deubiquitinating and deISGylating effects to restore host innate antiviral immune signaling. YL1004 inhibits the replication of wild-type, Delta, Omicron variants and nirmatrelvir-resistant strains of SARS-CoV-2. YL1004 can be used for the research of COVID-19 (SARS-CoV-2 infection) .
Cat. No.: HY-181262
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SARS-CoV-2 PLpro-IN-4 is a SARS-CoV-2 papain-like protease (PL Pro) inhibitor with an IC50 of 0.4 μM. SARS-CoV-2 PLpro-IN-4 binds to the S3 and S4 pockets of SARS-CoV-2 PL Pro, thereby functionally inhibiting its activity. SARS-CoV-2 PLpro-IN-4 exhibits antiviral activity and can be used in research on COVID-19 .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
