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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
93 Results for "
Atx
" in MedChemExpress (MCE) Product Catalog:
Products (93)
93 Results for "Atx" in MCE Product Catalog:
Cat. No.: HY-W725737
CAS No.: 944313-05-7
Target:
Research Areas:
BrP-LPA is a LPA antagonist/ATX inhibitor. BrP-LPA shows pan-antagonist activity towards LPA1-4 GPCRs. BrP-LPA decreases blood vessel density. BrP-LPA dose-dependently inhibits Lysophosphatidic acid-induced head-dip counts. BrP-LPA exhibits anticancer activity against breast cancer, colon cancer, and lung cancer. BrP-LPA inhibits anxiety-like behavior .
Cat. No.: HY-167201
CAS No.: 633278-53-2
Synonyms: 2ccPA18:1
Target:
Research Areas:
2ccPA (2ccPA18:1) is a metabolically stabilized carba analog of cyclic phosphatidic acid (cPA). 2ccPA inhibits autotaxin (ATX)‑mediated lysophosphatidic acid (LPA) production, suppresses extracellular matrix biosynthesis and elevates intracellular cAMP in fibrogenic skin fibroblasts. 2ccPA protects oligodendrocytes from mitochondrial‑driven apoptosis, suppresses neuroinflammation and demyelination, modulates microglial polarization and promotes rapid‑platelet/fibrin‑dependent hemostasis and subsequent fibrinolytic transition following brain injury .
Cat. No.: HY-179580
CAS No.: 3047548-70-6
Target:
Research Areas:
EL244 is a dua Autotaxin (ATX) (IC50 = 50 nM) inhibitor and PPARγ (IC50 = 1.3 μM; Kd = 1.3 μM) agonist. EL244 demonstrates low cytotoxicity in human HepG2 cells (EC50 = 81.2 μM) with minimal inhibition of the cardiac hERG potassium channel (12% at 25 μM). EL244 significantly reduces pulmonary Lysophosphatidic Acid (LPA) levels, attenuates fibrosis, and restores respiratory function with limited systemic absorption in vivo. EL244 can be used for idiopathic pulmonary fibrosis and interstitial lung disease (ILD) research .
Cat. No.: HY-P701460
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AtxN3L; Ataxin-3-Like Protein; Ataxin 3 Like; Putative Ataxin-3-Like Protein; MJDL; Ataxin 3-Like; Machado-Joseph Disease Protein 1-Like; Atx3L
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P810436
Synonyms: 61E3.4, Atx, hSMG-1, hSMG1, KIAA0421, Lambda interacting protein, Lambda-interacting protein, Lambda/iota protein kinase C interacting protein, Lambda/iota protein kinase C-interacting protein, LIP
Cat. No.: HY-P701461
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AtxN3L; Ataxin-3-Like Protein; Ataxin 3 Like; Putative Ataxin-3-Like Protein; MJDL; Ataxin 3-Like; Machado-Joseph Disease Protein 1-Like; Atx3L
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P75733
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ENPP2; LysoPLD; Prev. PDNP2; Phosphodiesterase I/Nucleotide Pyrophosphatase 2; Autotaxin; Plasma Lysophospholipase D; Atx; Alternative Protein ENPP2; Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2; Autotaxin-T; Extracellular Lysophosphol
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P703781
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ENPP2; LysoPLD; Prev. PDNP2; Phosphodiesterase I/Nucleotide Pyrophosphatase 2; Autotaxin; Plasma Lysophospholipase D; Atx; Alternative Protein ENPP2; Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2; Autotaxin-T; Extracellular Lysophosphol
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P79153
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Botulinum neurotoxin type A2; BoNT/A; BoNTA2; Bontoxilysin-A; BOTOX; Botulinum neurotoxin A2 light chain (LC); EC:3.4.24.69; Botulinum neurotoxin A2 heavy chain (HC); botA; Atx; bna; bonT; bont/a2; CLM_0897
Species:
Others
Source:
P. pastoris
Cat. No.: HY-P79456
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AtxN3; MJD1; Prev. SCA3; Olivopontocerebellar Ataxia 3; Prev. MJD; Ubiquitinyl Hydrolase 1; Atx3; Ataxin 3 Variant An; JOS; Ataxin 3 Variant H; Spinocerebellar Ataxia Type 3 Protein; Ataxin 3 Variant E; Machado-Joseph Disease Protein 1; Josephin; Ataxin-3
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
