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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
136 Results for "
non-nucleoside reverse-transcriptase
" in MedChemExpress (MCE) Product Catalog:
Products (136)
136 Results for "non-nucleoside reverse-transcriptase" in MCE Product Catalog:
Cat. No.: HY-151933
CAS No.: 3038135-11-1
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HIV-1 inhibitor-49 is an orally active HIV-1 inhibitor, is a HEPT analog. HIV-1 inhibitor-49 possesses great pharmacokinetics profiles and potent non-nucleoside reverse transcriptase inhibitory activity (IC50=30 nM). HIV-1 inhibitor-49 exerts potential safety without acute toxicity in mouse model .
Cat. No.: HY-142073
CAS No.: 183904-53-2
Synonyms: DHCal A; NSC 678323
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(+)-Dihydrocalanolide A (DHCal A; NSC 678323) is an orally active nonnucleoside inhibitor of Reverse Transcriptase. (+)-Dihydrocalanolide A can be used to HIV infection research .
Cat. No.: HY-144113
CAS No.: 2761172-65-8
HIV-1 inhibitor-14 (compound 14b) is a highly potent and broad-spectrum HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor with an EC50 of 0.14 μM for HIV-1 RT. HIV-1 inhibitor-14 has inhibitory activity against HIV-1 WT and resistant strains with EC50s of 5.79 ~ 28.3 nM .
Cat. No.: HY-146746
CAS No.: 2649837-82-9
HIV-1 inhibitor-19 is a potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI). HIV-1 inhibitor-19 maintains its inhibitory activity against L100I, K103N and V106A/ F227L mutant strains with EC50s of 7.3 nM, 9.2 nM and 21.0 nM, respectively.
Cat. No.: HY-10574AR
CAS No.: 700361-47-3
Synonyms: TMC-278 hydrochloride (Standard); TMC278 hydrochloride (Standard); TMC 278 hydrochloride (Standard)
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Rilpivirine (hydrochloride) (Standard) is the analytical standard of Rilpivirine (hydrochloride). This product is intended for research and analytical applications. Rilpivirine (R278474) hydrochloride is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine hydrochloride has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine hydrochloride has a high genetic barrier to resistance development of HIV .
Cat. No.: HY-10574R
CAS No.: 500287-72-9
Synonyms: R278474 (Standard); TMC278 (Standard); DB08864 (Standard)
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Rilpivirine (Standard) is the analytical standard of Rilpivirine. This product is intended for research and analytical applications. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .
Cat. No.: HY-10574S1
Synonyms: R278474-13C6; TMC278-13C6; DB08864-13C6
Cat. No.: HY-146018
CAS No.: 2554622-28-3
HIV-1 inhibitor-23 (compound 12a) is a highly potent HIV-1 non-nucleoside reverse transcriptase inhibitor, with EC50s of 24.9 nM and 10.4 nM for HIV-1 WT and HIV-1 K103N, respectively. HIV-1 inhibitor-23 has low cytotoxicity (CC50 > 221 μM) and a favorable in vitro microsomal stability .
Cat. No.: HY-17396R
CAS No.: 101827-46-7
Synonyms: KP363 Hydrochloride (Standard)
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Rilpivirine (hydrochloride) (Standard) is the analytical standard of Rilpivirine (hydrochloride). This product is intended for research and analytical applications. Rilpivirine (R278474) hydrochloride is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine hydrochloride has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine hydrochloride has a high genetic barrier to resistance development of HIV .
Cat. No.: HY-182497
CAS No.: 177577-59-2
U 95133 is a non-nucleoside reverse transcriptase inhibitor. U 95133 exhibits activity against both wild-type and mutant HIV-1 reverse transcriptase. U 95133 can be used in studies related to HIV infection .
Cat. No.: HY-10570S3
CAS No.: 1189717-29-0
Synonyms: BI-RG 587-d5; NSC 641530-d5; NVP-d5
Cat. No.: HY-108930
CAS No.: 244268-79-9
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HI-207 is a non-nucleoside reverse transcriptase inhibitor. HI-207 has anti-HIV activity (PBMC/p24 inhibition assay: IC50 = 0.27 μM). HI-207 can be used for HIV infection research .
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Cat. No.: HY-111147
CAS No.: 914496-19-8
RDEA-427 is a pyrrolopyrimidine derivative and also a HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI). RDEA-427 acts on wild-type and NNRTI-resistant mutant HIV-1. RDEA-427 can be used in research related to HIV infection .
Cat. No.: HY-181090
HIV-1-IN-92 is a non-nucleoside inhibitor of HIV-1 reverse transcriptase with an IC50 of 0.11 μM against HIV-1 reverse transcriptase. HIV-1-IN-92 exhibits activity against both wild-type HIV-1 IIIB and mutant HIV-1 strains. HIV-1-IN-92 can be used in research related to acquired immunodeficiency syndrome (AIDS) .
Cat. No.: HY-187616
CAS No.: 163435-77-6
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R-95845 is a non-nucleoside HIV-1 reverse transcriptase (RT) inhibitor. R-95845 is specific to HIV-1 RT and acts as a functionally non-competitive inhibitor with respect to nucleotide incorporation. R-95845 binds to the non-nucleoside inhibitor binding pocket of HIV-1 RT in a butterfly-like conformation, forms hydrogen bonds with Tyr 188 and Val 189, and engages in hydrophobic interactions with surrounding residues. R-95845 can be used in studies related to HIV-1 infection and acquired immunodeficiency syndrome .
Cat. No.: HY-187625
CAS No.: 153312-20-0
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Tgg-II-23A is a non-nucleoside HIV-1 reverse transcriptase inhibitor, with an IC50 of 136 μM against HIV-1 NL4-3 reverse transcriptase . Tgg-II-23A exhibits antiviral activity against wild-type HIV-1, but shows reduced activity against TIBO R82150 (HY-19111)-resistant HIV-1 strains carrying reverse transcriptase mutations. Tgg-II-23A does not inhibit the replication of HIV-2. Tgg-II-23A can be used in studies related to HIV-1 infection .
Cat. No.: HY-189211
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NNRT-IN-17 is a non-nucleoside HIV-1 Reverse Transcriptase inhibitor with an IC50 of 0.095 μM. NNRT-IN-17 exerts its inhibitory effect by binding to the NNRTI binding pocket and adjacent sites, and exhibits antiviral activity against wild-type and multiple NNRTI-resistant mutant strains. NNRT-IN-17 can be used for the study of HIV-1 infection (AIDS) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
