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Art. -Nr.: HY-182497

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U 95133

U 95133 is a non-nucleoside reverse transcriptase inhibitor. U 95133 exhibits activity against both wild-type and mutant HIV-1 reverse transcriptase. U 95133 can be used in studies related to HIV infection.

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CAS. Nr.: 177577-59-2
Formel: C₂₅H₃₄N₆O₃S
Molecular Weight:498.64

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

U 95133 Chemical Structure

CAS. Nr.: 177577-59-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle HIV Isoform-spezifische Produkte anzeigen :

In Vitro

U 95133 (compound 16) (0-100 μM) potently inhibits wild-type HIV-1 reverse transcriptase, with an IC₅₀ of 2.2 μM and an inhibition rate of 98% at a concentration of 100 μM^[1].
U 95133 potently inhibits HIV-1 replication in human peripheral blood mononuclear cells, with an ED₅₀ of <0.0001 μM^[1].
U 95133 (10 minutes) exhibits an IC₅₀ of 0.50 μM against wild-type HIV-1 reverse transcriptase, an IC₅₀ of 1.5 μM against HIV-1 reverse transcriptase ^P236L, and an IC₅₀ of 1.1 μM against HIV-1 reverse transcriptase ^Y181C^[1].
U 95133 (4 days) potently inhibits the replication of wild-type HIV-1_IIIB in MT4 cells with an IC₉₀ of 0.02 μM, and exhibits submicromolar activity against a variety of NNRTI-resistant HIV-1 variants^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

U 95133 (15 mg/kg; i.v.; p.o.) exhibits high intravenous clearance and low oral bioavailability in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 177577-59-2
Molecular Weight 498.64
Formel C₂₅H₃₄N₆O₃S
SMILES

O=C(N1CCC(CC1)N(C)C2=NC=CC=C2NC(C)(C)C)C3=CC4=C(N3)C=CC(NS(=O)(C)=O)=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Genin MJ, et al. Synthesis and bioactivity of novel bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs. J Med Chem. 1996;39(26):5267-5275. [Content Brief]

[2]. Olmsted R A, et al. (Alkylamino) piperidine bis (heteroaryl) piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes. Journal of virology, 1996, 70(6): 3698-3705.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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U 95133

Alle HIV Isoform-spezifische Produkte anzeigen