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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
123 Results for "
Integrase
" in MedChemExpress (MCE) Product Catalog:
Products (123)
123 Results for "Integrase" in MCE Product Catalog:
Cat. No.: HY-N0457AR
CAS No.: 70831-56-0
Synonyms: (-)-Chicoric acid (Standard); trans-Caffeoyltartaric acid (Standard)
Cat. No.: HY-182277
CAS No.: 1392118-63-6
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GSK-1264 is an HIV-1 integrase inhibitor. GSK-1264 binds to a site spanning the HIV-1 integrase catalytic core domain and C-terminal domain, mediates formation of an open polymer of HIV-1 integrase dimers via inhibitor-bridged contacts between adjacent dimers. GSK-1264 disrupts late-stage HIV replication by interfering with viral particle assembly. GSK-1264 stimulates inappropriate polymerization of HIV-1 integrase. GSK-1264 can be used for the research of HIV infection .
Cat. No.: HY-N20732
CAS No.: 871949-32-5
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Cat. No.: HY-187868
CAS No.: 2395803-51-5
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Fexategravir is a HIV integrase inhibitor. Fexategravir exhibits antiviral activity. Fexategravir can be used for the research of HIV infection .
Cat. No.: HY-123883
CAS No.: 865298-81-3
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MK-0536 is a highly potent HIV-1 integrase inhibitor that effectively suppresses the replication of wild-type viruses. MK-0536 retains significant antiviral activity against multiple key drug-resistant mutants such as Y143R and N155H, and shows no toxicity to uninfected cells. MK-0536 selectively blocks the strand transfer reaction of integrase by chelating magnesium ions at the active site and interacting with viral DNA and enzyme residues. MK-0536 is applicable to the study of HIV infection mechanisms .
Cat. No.: HY-N18192
CAS No.: 88524-65-6
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Cat. No.: HY-W781966
CAS No.: 1357289-37-2
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4-epi-Dolutegravir (compound H3) is the (4S, 12aS) diastereomer of Dolutegravir (HY-13238), and also a hydrolytic degradation product of a HIV integrase inhibitor .
Cat. No.: HY-185448
CAS No.: 1246741-36-5
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HIV RT-IN-1 is an inhibitor of HIV integrase and HIV reverse transcriptase-associated ribonuclease H. HIV RT-IN-1 is applicable to research related to HIV-1 infection .
Cat. No.: HY-108818R
CAS No.: 1638504-52-5
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XZ426 (Standard) is the analytical standard of XZ426 (HY-108818). This product is intended for research and analytical applications. XZ426 is a potent integrase strand transfer inhibitor with anti- HIV activity .
Cat. No.: HY-183926
CAS No.: 384361-09-5
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D719 is an HIV-1 integrase inhibitor. D719 binds to the hydrophobic pocket of HIV-1 integrase CCD dimer, disrupts interaction with LEDGF/P75, and prevents integrase nuclear translocation. D719 reduces HIV-1 p24 antigen production in acute infection of human T cells. D719 can be used for the research of HIV infection .
Cat. No.: HY-178833
CAS No.: 180740-99-2
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CNI-H0294 hydrochloride is a selective HIV-1 integrase inhibitor. CNI-H0294 hydrochloride is promising for research of HIV-associated central nervous system diseases .
Cat. No.: HY-135210
CAS No.: 223393-69-9
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V-165 is an inhibitor of HIV Integrase and HIV Reverse transcriptase, with an IC50 value of 3.8 μM against HIV integrase and an IC50 value of 4.8 μM against HIV reverse transcriptase. V-165 inhibits HIV-1 replication. V-165 can be used in studies related to immunodeficiency virus infections .
Cat. No.: HY-184318
CAS No.: 915407-80-6
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GS-9160 is a HIV-1 integrase strand transfer inhibitor with an IC50 of 28 nM. GS-9160 elevates the level of HIV-1 double long terminal repeat circles and reduces integration junctions. GS-9160 exhibits selective antiviral activity against HIV-1 in cells. GS-9160 can select for integrase mutants E92V and L74M, and shows synergistic activity with other HIV-1 inhibitors. GS-9160 can be used in studies related to HIV-1 infection .
Cat. No.: HY-182678
CAS No.: 251922-77-7
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L-731988 is an inhibitor targeting HIV-1 integrase. L-731988 inhibits HIV-1 replication by blocking integrase function. L-731988 exhibits ED50 values ranging from 0.5 μM to 3.14 μM against various HIV-1 isolates. L-731988 can be used for the research of human immunodeficiency virus type 1 (HIV-1) infection .
Cat. No.: HY-N17982
CAS No.: 879627-80-2
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Cat. No.: HY-184700
CAS No.: 3124729-94-5
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HIV-1-IN-94 is a dual inhibitor of HIV-1 integrase (INST) and reverse transcriptase RNase H, with IC50 values of 12 μM and 0.11 μM, respectively. HIV-1-IN-94 inhibits HIV-1 replication with low cytotoxicity. HIV-1-IN-94 can be used in studies related to HIV-1 infection .
Cat. No.: HY-N15438
CAS No.: 35815-07-7
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Cat. No.: HY-10353R
CAS No.: 518048-05-0
Synonyms: MK-0518 (Standard)
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Raltegravir (Standard) is the analytical standard of Raltegravir (HY-10353). This product is intended for research and analytical applications. Raltegravir is a potent integrase (IN) inhibitor, used to treat HIV infection.
Cat. No.: HY-W876243
CAS No.: 1244-78-6
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Averionol (Compound 26) is a flavonoid compound. Averionol has no significant inhibitory activity against HIV integrase. Averionol can be used in the development of anti-HIV agents .
Cat. No.: HY-50693
CAS No.: 900779-63-7
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5 CITEP is a potent HIV integrase inhibitor; its IC50s by multiple MIA and MPA are 2.3 ± 0.1 μM and 2.1 ± 0.1 μM, respectively.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
