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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
202 Results for "
outer S5/S6 helices
" in MedChemExpress (MCE) Product Catalog:
Products (202)
202 Results for "outer S5/S6 helices" in MCE Product Catalog:
Cat. No.: HY-123803
CAS No.: 2213468-04-1
Target:
Research Areas:
PF-06807656 is a selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor. PF-06807656 has an IC50 of 61 nM against hROMK in patch-clamp assays. PF-06807656 exhibits high selectivity for inhibiting rat ROMK and is insensitive to N171D pore mutations. PF-06807656 may be used in cardiovascular disease research .
Cat. No.: HY-P72279
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: outer membrane porin F; outer membrane protein 1A; outer membrane protein B; outer membrane protein F; outer membrane protein IA; Porin OmpF; ompF; cmlB; coa; cry; tolF; JW0912; b0929
Species:
E.coli
Source:
E. coli
Cat. No.: HY-P705718
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: outer membrane protein Omp38; outer membrane protein OmpA; AbOmpA; outer membrane protein OmpAb; omp38; ompA
Species:
Others
Source:
E. coli
Cat. No.: HY-187529
CAS No.: 1144496-95-6
PUN-96956 is an inhibitor of the β-barrel assembly machine (BAM) complex. By inhibiting the folding of β-barrel outer membrane proteins (OMPs) and their insertion into the outer membrane, PUN-96956 disrupts outer membrane integrity and induces the cell envelope stress response. PUN-96956 can be used in studies of bacterial infections caused by ESKAPE pathogens, uropathogenic Escherichia coli, and Gram-positive bacteria .
Cat. No.: HY-P704055
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Major outer membrane porin, serovar C; ompA; omp1; omp1C; Major outer membrane porin; serovar C; MOMP
Species:
Others
Source:
E. coli
Target:
Research Areas:
Cat. No.: HY-N18794
CAS No.: 68553-81-1
Cat. No.: HY-168880
CAS No.: 2254335-06-1
Target:
Research Areas:
ROMK-IN-2 (compond 1) is a potent renal outer medullary potassium (ROMK) inhibitor .
Cat. No.: HY-403689
CAS No.: 1095275-70-9
Target:
Research Areas:
Cat. No.: HY-P70136
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CYB5B; Cytochrome B5 outer Mitochondrial Membrane Isoform; Cytochrome B5 Type B; outer Mitochondrial Membrane Cytochrome B5; CYB5-M; Type 2 Cyt-B5; Cytochrome B5 Type B (outer Mitochondrial Membrane); CYPB5M; OMB5; CYB5M
Species:
Human
Source:
HEK293
Cat. No.: HY-L0119V
3,253 compounds
Protein protein interactions (PPI) have pivotal roles in life processes. The studies showed that aberrant PPI are associated with various diseases. However, the design of modulators targeting PPI still faces tremendous challenges, such the difficult PPI interfaces for the drug design, lack of ligands reference, lack of guidance rules for the PPI modulators development and high-resolution PPI proteins structures.
The PPI Library comprises molecules of various sizes, frameworks, and shapes ranging from fragment-like entities to macrocyclic derivatives designed as secondary structure mimetics or as epitope mimetics. The designs cover β-turn / loop mimetics and α-helix mimetics. Since helices present at the interface in 62% of all protein-protein interactions. This library focused on designs including mimics with the substitution geometry of an a-helices, as well as designs that mimic the location of “hot-spot” side chains in helix-mediated PPIs.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
