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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
157 Results for "
fraction
" in MedChemExpress (MCE) Product Catalog:
Products (157)
157 Results for "fraction" in MCE Product Catalog:
Cat. No.: HY-187661
CAS No.: 42408-79-7
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Pirandamine free base is a selective serotonin (5-HT) (HY-B1473A) uptake inhibitor with an IC50 of 250 nM. It exerts antidepressant-like effects by enhancing central serotonergic function, does not inhibit norepinephrine (HY-13715) uptake, and exhibits no central anticholinergic or monoamine oxidase inhibitory activity. Pirandamine free base is used in the study of depression .
Cat. No.: HY-W040264
CAS No.: 911660-54-3
Synonyms: Lanostenol
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Triterpenes Capsicum annuum L. Terpenoids Other Diseases Plants Solanaceae Disease Research Fields
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Cat. No.: HY-10486
CAS No.: 361444-66-8
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JDTic is a blood-brain barrier-permeable κ-opioid receptor antagonist (Ki=0.02 nM) with favorable in vitro ADME properties. JDTic blocks agonist-mediated Gi and β-arrestin signaling pathways as well as analgesic effects by stabilizing the inactive conformation of hKOR and activating JNK. JDTic may also induce transient asymptomatic ventricular tachycardia. JDTic is widely applicable to studies related to depression, anxiety, stress-induced addictive behaviors, and nicotine withdrawal .
Cat. No.: HY-182948
CAS No.: 2089135-65-7
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Dichloro-all-trans-retinone is a selective retinaldehyde dehydrogenase (RALDH) inhibitor, with an IC50 of 434.7 nM and a Ki of 194.4 nM against chicken RALDH1; an IC50 of 55 nM and a Ki of 5.1 nM against chicken RALDH2; an IC50 of 191.32 nM and a Ki of 64.35 nM against human RALDH2; and an IC50 of 161.27 nM and a Ki of 6.74 nM against chicken RALDH3. Dichloro-all-trans-retinone inhibits the synthesis of all-trans retinoic acid (ATRA). Dichloro-all-trans-retinone is applicable to research related to form-deprivation-induced myopia .
Cat. No.: HY-B1803
CAS No.: 41094-88-6
Synonyms: ICI 136753
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Tracazolate (ICI 136753) is an orally active non-benzodiazepine anxiolytic. Tracazolate significantly enhances the binding of the radioligand 3H-flunitrazepam ( 3H-FLU) to brain tissue benzodiazepine receptors. Tracazolate enhances the binding of γ-aminobutyric acid (GABA) to its receptors. Tracazolate exhibits anticonvulsant activity. Tracazolate can be used in anxiety-related research .
Cat. No.: HY-116755
CAS No.: 55837-29-1
Synonyms: CR 605
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Tiropramide (CR 605) is a tyrosine derivative with antispastic properties. Tiropramide hydrochloride inhibits phosphodiesterase activity involved in cAMP catabolism in rabbit colon homogenates. Tiropramide relaxes smooth muscle in rabbit isolated colon. Tiropramide can be used for the research of irritable colon and biliary dyskinesia .
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N-Isopropylhydroxylamine is an alkylhydroxylamine and also a synthetic precursor of N-hydroxypropranolol. N-Isopropylhydroxylamine can be used in studies on the synthesis of metabolic derivatives of β-adrenergic receptor antagonists .
Cat. No.: HY-43934
CAS No.: 53567-47-8
Synonyms: CR 605 hydrochloride
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Tiropramide (CR 605) hydrochloride is a tyrosine derivative with antispastic properties. Tiropramide hydrochloride inhibits phosphodiesterase activity involved in cAMP catabolism in rabbit colon homogenates. Tiropramide hydrochloride relaxes smooth muscle in rabbit isolated colon. Tiropramide hydrochloride can be used for the research of irritable colon and biliary dyskinesia .
Cat. No.: HY-N21981
CAS No.: 87095-76-9
Category:
Simple Phenylpropanols Scrophulariaceae Phenylpropanoids Plants Bacopa monnieri (Linn.) Wettst. Zingiberaceae Curcuma comosa Roxb.
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Synonyms: AZD9977
Research Areas:
Balcinrenone (AZD9977) is an orally active mineralocorticoid receptor modulator. Balcinrenone regulates mineralocorticoid receptor activity, inhibits aldosterone-induced target gene expression, and suppresses the activities of renal Toll-like receptor 4, MyD88 and NF-κB. Balcinrenone alleviates renal extracellular matrix remodeling, inflammatory cell infiltration, and the expression of renal injury markers. Balcinrenone restores myocardial perfusion reserve, regulates potassium homeostasis, and induces fecal potassium excretion. Balcinrenone is applicable to research on metabolism-related chronic kidney disease and heart failure .
Cat. No.: HY-120274A
CAS No.: 1850385-65-7
Synonyms: (R)-AZD9977
Research Areas:
(R)-Balcinrenone ((R)-AZD9977) is an isomer of Balcinrenone (HY-120274). Balcinrenone is an orally active mineralocorticoid receptor modulator. Balcinrenone regulates mineralocorticoid receptor activity, inhibits aldosterone-induced target gene expression, and suppresses the activities of renal Toll-like receptor 4, MyD88 and NF-κB. Balcinrenone alleviates renal extracellular matrix remodeling, inflammatory cell infiltration, and the expression of renal injury markers. Balcinrenone restores myocardial perfusion reserve, regulates potassium homeostasis, and induces fecal potassium excretion. Balcinrenone is applicable to research on metabolism-related chronic kidney disease and heart failure .
Cat. No.: HY-45609
CAS No.: 150465-29-5
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Cat. No.: HY-NP0196I
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Rabbit IgG Fab fragment-AF488 is an AF488-labeled rabbit IgG Fab fragment .
Cat. No.: HY-W127317
CAS No.: 102850-29-3
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Cat. No.: HY-W788040
CAS No.: 1246355-68-9
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Inositol 1,3,4,5-tetraphosphate tetraammonium is an inositol tetraphosphate. Inositol 1,3,4,5-tetraphosphate tetraammonium is metabolically produced from Ins (1,4,5) P3 via 3-kinase, participates in intracellular signal transduction systems, and elevates intracellular calcium concentrations when present .
Cat. No.: HY-182566
CAS No.: 288246-59-3
ITI-367 is a HIV-1 inhibitor that targets the nuclear localization signal 1 (NLS-1) of HIV-1 matrix protein and the interaction between HIV-1 pre-integration complex (PIC) and importin-β. ITI-367 inhibits HIV-1 replication at the pre-integration stage, reduces the formation of 2-LTR circles, and sequesters viral DNA in the cytoplasm. ITI-367 can be used for the research of HIV infection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
