8 Results for "

β-Muricholic acid

" in MedChemExpress (MCE) Product Catalog:
Products (8)

8 Results for "β-Muricholic acid" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-133707
CAS No.: 2393-59-1
Purity:  99.91%
β-Muricholic acid is a potent and orally active biliary cholesterol-desaturating agent. β-Muricholic acid prevents cholesterol gallstones. β-Muricholic acid inhibits lipid accumulation. β-Muricholic acid has the potential for the research of nonalcoholic fatty liver disease (NAFLD) .
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6
6 Publications Verification
Cat. No.: HY-135103
CAS No.: 145022-92-0
Purity:  98.60%
Synonyms: T-βMCA sodium
Target:  

FXR

Research Areas:  

Cancer

Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM .
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6
6 Publications Verification
Cat. No.: HY-N9933
CAS No.: 25696-60-0
Synonyms: TβMCA
Tauro-β-muricholic acid (TβMCA) is an orally active trihydroxylated bile acid and a competitive, reversible FXR antagonist (IC50=40 μM). Tauro-β-muricholic acid inhibits bile acid-induced hepatocyte apoptosis by maintaining mitochondrial membrane potential, while simultaneously inhibiting intestinal FXR signaling, affecting bile acid synthesis, hepatic lipid metabolism, and insulin sensitivity. Accumulation of tauro-β-muricholic acid disrupts metabolic homeostasis, promoting cancer stem cell proliferation and tumor progression. The mechanisms of tauro-β-muricholic acid involve two aspects: first, inhibiting the translocation of the pro-apoptotic protein Bax to mitochondria and maintaining mitochondrial membrane potential (MMP); and second, blocking the FXR signaling pathway to regulate bile acid metabolism, reduce serum ceramide production, and downregulate the hepatic SREBP1C/CIDEA pathway. Tauro-β-muricholic acid possesses anti-hepatocyte apoptosis, bile acid homeostasis regulation, and liver fat accumulation reduction properties, and also functions as a biomarker, making it useful in the study of diseases such as bile acid metabolism disorders, non-alcoholic fatty liver disease, colorectal cancer, and liver fibrosis .
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Cat. No.: HY-133707R
CAS No.: 2393-59-1
Deracoxib (Standard) is the analytical standard of Deracoxib. This product is intended for research and analytical applications. 0
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Cat. No.: HY-133707S1
β-Muricholic acid-d4 is the deuterium labeled β-Muricholic acid .
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Cat. No.: HY-133707S
CAS No.: 2725726-62-3
β-Muricholic acid-d5 is the deuterium labeled β-Muricholic acid .
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Cat. No.: HY-135103S
Tauro-β-muricholic acid-d4 (sodium) is the deuterium labeled Tauro-β-muricholic acid sodium. Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM .
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Cat. No.: HY-N9933S
Synonyms: T-βMCA-d4-1 sodium
Tauro-β-muricholic acid-d4-1 (T-βMCA-d4-1) sodium is the deuterium labeled Tauro-β-muricholic acid (HY-N9933) .
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