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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
TCN
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "TCN" in MCE Product Catalog:
23
23 Cited Publications
Synonyms: API-2; NSC 154020; TCN
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Triciribine is a DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively.
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1 Cited Publications
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TCN 201 is a potent, selective and non-competitive antagonist of GluN1/GluN2A NMDA receptor, with a pIC50 of 6.8. TCN 201 is selective for GluN1/GluN2A NMDA receptor over GluN1/GluN2B NMDA receptor (pIC50<4.3) .
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TC-N 1752 is a potent and orally active inhibitor of Nav1.7, with IC50s of 0.17 μM, 0.3 μM, 0.4 μM, 1.1 μM and 2.2 μM at hNav1.7, hNav1.3, hNav1.4, hNaV1.5 and rNav1.8, respectively. TC-N 1752 also inhibits tetrodotoxin-sensitive sodium channels. TC-N 1752 shows analgesic efficacy in the Formalin model of pain .
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TCN238 is an orally bioavailable mGlu4 receptor positive allosteric modulator (PAM) with an EC50 of 1 μM .
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TCN 213 is a selective, surmountable, glycine-dependentlly GluN1/GluN2A NMDAR antagonist with IC50s of 0.55, 3.5, 40 μM in the presence of 75, 750, 7500 nM glycine, respectively. TCN 213 can be used to monitor, pharmacologically, the switch in NMDAR expression in developing cortical neurones .
Cat. No.: HY-10250
CAS No.: 61966-08-3
Synonyms: TCN-P
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Triciribine phosphate (TCN-P) inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate also inhibits IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity .
Cat. No.: HY-107405S
Cat. No.: HY-18679
CAS No.: 1314140-00-5
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TC-N 22A is a potent, selective, orally active and brain-permeable mGlu4 PAM with an EC50 of 9 nM in human mGlu4-expressing BHK cells. TC-N 22A is less active (EC50>10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo .
Cat. No.: HY-RS14318
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TCN1 Human Pre-designed siRNA Set A contains three designed siRNAs for TCN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS14319
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TCN2 Human Pre-designed siRNA Set A contains three designed siRNAs for TCN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19166
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Tcn2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tcn2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-10250S1
Synonyms: TCN-P-d3
Cat. No.: HY-10250A
Purity: 99.82%
Synonyms: TCN-P sodium
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Triciribine phosphate sodium inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate sodium also inhibits IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity .
Cat. No.: HY-107405R
CAS No.: 1211866-85-1
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TC-N 1752 (Standard) is the analytical standard of TC-N 1752 (HY-107405). This product is intended for research and analytical applications. TC-N 1752 is a potent and orally active inhibitor of Nav1.7, with IC50s of 0.17 μM, 0.3 μM, 0.4 μM, 1.1 μM and 2.2 μM at hNav1.7, hNav1.3, hNav1.4, hNaV1.5 and rNav1.8, respectively. TC-N 1752 also inhibits tetrodotoxin-sensitive sodium channels. TC-N 1752 shows analgesic efficacy in the Formalin model of pain .
Cat. No.: HY-RS25655
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Tcn2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tcn2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P76102A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Transcobalamin-2; TC-2; TCII; TCN2
Cat. No.: HY-P700085AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Gastric intrinsic factor; GIF; IF; Intrinsic factor; IFMH; INF; TCN3
Cat. No.: HY-P71789
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Haptocorin; Haptocorrin; HC; Transcobalamin 1; Vitamin B12 binding protein; Vitamin B12 binding protein R binder family
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
