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A4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (2) Akt (1) Aldose Reductase (1) Aminopeptidase (23) Amyloid-β (3) Androgen Receptor (1) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (14) Apoptosis (5) Arf Family GTPase (1) Bacterial (16) Bcl-2 Family (1) Biochemical Assay Reagents (25) BMX Kinase (1) c-Myc (1) Cadherin (1) Calcium Channel (1) Carboxylesterase (CES) (1) CDK (1) Chloride Channel (1) Cholinesterase (ChE) (1) COX (1) CXCR (1) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (8) Dengue Virus (1) Drug Derivative (4) Drug Intermediate (1) Drug Metabolite (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (7) Enolase (2) Environmental Pollutants (2) Ephrin Receptor (1) Epigenetic Reader Domain (1) Fluorescent Dye (2) Formyl Peptide Receptor (FPR) (1) Fungal (1) GABA Receptor (1) Glutathione S-transferase (1) Glycosidase (1) Glycosyltransferase (1) Herbicide (1) Histamine Receptor (1) Histone Demethylase (1) IFNAR (1) Influenza Virus (1) Insecticide (1) Interleukin Related (3) Isotope-Labeled Compounds (6) JNK (1) Leukotriene Receptor (4) Liposome (2) Lipoxygenase (2) LXR (1) Mas-related G-protein-coupled Receptor (MRGPR) (1) MHC (1) Microtubule/Tubulin (7) MOFs (2) Neurokinin Receptor (8) Neuropeptide Y Receptor (1) NF-κB (1) Opioid Receptor (1) P-glycoprotein (2) Parasite (5) PD-1/PD-L1 (1) Phosphodiesterase (PDE) (2) Proteasome (1) Protoporphyrinogen IX oxidase (1) Reference Standards (10) SARS-CoV (1) Small Interfering RNA (siRNA) (73) STAT (2) Trk Receptor (1) UGT (1) VEGFR (1)
By Research Areas:	Cancer (47) Cardiovascular Disease (4) Endocrinology (3) Infection (28) Inflammation/Immunology (36) Metabolic Disease (26) Neurological Disease (19)
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Oligonucleotides:	Pegylated Lipids (2) Rat Pre-designed siRNA Sets (17) Mouse Pre-designed siRNA Sets (16) Human Pre-designed siRNA Sets (40) siRNAs (73)

232

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0134

Bestatin Maximum Cited Publications 11 Publications Verification Ubenimex	Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects .

HY-N2146

Combretastatin A4 4 Publications Verification CRC 87-09	Microtubule/Tubulin	Cancer
Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with K_d of 0.4 μM.

HY-15858

AP-III-a4 Maximum Cited Publications 16 Publications Verification ENOblock	Enolase Apoptosis	Metabolic Disease Cancer
AP-III-a4 (ENOblock) is a nonsubstrate analogue enolase inhibitor with an IC₅₀ of 0.576 uM. AP-III-a4 can be used for the research of cancer and diabetic .

HY-N8440

Gibberellin A4	NF-κB	Infection
Gibberellin A4 is a type of bioactive gibberellin. Gibberellin A4 promotes flowering in apple trees. Gibberellin A4 also exhibits anti-NF-κB and antioxidant activities. Gibberellin A4 can be used in the research of periodontal diseases .

HY-B0134A

Bestatin hydrochloride Maximum Cited Publications 11 Publications Verification Ubenimex hydrochloride	Antibiotic Bacterial Aminopeptidase	Infection Cancer
Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

HY-17449

Fosbretabulin disodium CA 4DP; CA 4P; Combretastatin A4 disodium phosphate	Microtubule/Tubulin Apoptosis	Cancer
Fosbretabulin disodium (CA 4DP) is a tubulin destabilizing agent. Fosbretabulin disodium is the Combretastatin A4 proagent that selectively targets endothelial cells, induces regression of nascent tumour neovessels, reduces tumour blood flow and causes central tumour necrosis .

HY-113509

Lipoxin A4 1 Publications Verification LXA4	Interleukin Related Endogenous Metabolite	Inflammation/Immunology
Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties . Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways . Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC₅₀ value of 25.74 nM .

HY-B0778

Milbemycin oxime 1 Publications Verification	Antibiotic Parasite	Infection
Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .

HY-15858A

AP-III-a4 hydrochloride Maximum Cited Publications 16 Publications Verification ENOblock hydrochloride	Enolase Apoptosis	Metabolic Disease Cancer
AP-III-a4 (ENOblock) hydrochloride is a nonsubstrate analogue enolase inhibitor with an IC₅₀ of 0.576 uM. AP-III-a4 hydrochloride can be used for the research of cancer and diabetic .

HY-137298

LYS006 LTA4H-IN-1	Aminopeptidase	Inflammation/Immunology
LTA4H-IN-1 is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) extracted from patent WO2015092740A1, example 29, has an IC₅₀ of 2 nM. LTA4H-IN-1 can be used for the research of inflammatory and autoimmune disorders .

HY-P990363

Anti-CDH17/Cadherin-17 Antibody (PTA001_A4) PTA001_A4	Cadherin	Cancer
The Anti-CDH17/Cadherin-17 Antibody (PTA001_A4) is a humanized antibody expressed in CHO cells, targeting CDH17/Cadherin-17. The Anti-CDH17/Cadherin-17 Antibody (PTA001_A4) features an IgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 149.12 kDa. The isotype control for the Anti-CDH17/Cadherin-17 Antibody (PTA001_A4) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-17625

Acebilustat 1 Publications Verification CTX-4430	Aminopeptidase	Inflammation/Immunology
Acebilustat (CTX-4430) is a leukotriene A4 hydrolase inhibitor, used for an oral antiinflammatory agent.

HY-124071

ACT-389949	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
ACT-389949 is a first-in-class, potent and selective and agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC₅₀ of 3 nM for FPR2/ALX internalization into monocytes. ACT-389949 has potential for the treatment of inflammatory disorders .

HY-N4146

Proanthocyanidin A4	Others	Inflammation/Immunology
Proanthocyanidin A4 is a polyphenol found in a variety of plants. Proanthocyanidin A4 possesses anti-inflammatory effects .

HY-126906

Milbemycin A4	Environmental Pollutants Antibiotic P-glycoprotein	Cancer
Milbemycin A4 inhibits P-glycoprotein activity, and reverses multidrug resistance of tumor cells. Milbemycins are a family of macrolide antibiotics with insecticidal and acaricidal activity sup>[2].

HY-124129

10074-A4	c-Myc	Cancer
10074-A4 is a c-Myc inhibitor. 10074-A4 could bind to c-Myc_370-409 at different sites along the peptide chain. 10074-A4 has anticancer effects .

HY-113509B

15(R)-Lipoxin A4 15-epi-LXA4	STAT COX Lipoxygenase JNK Endogenous Metabolite	Neurological Disease Inflammation/Immunology
15 (R)-Lipoxin A4 (15-epi-LXA4) is a specialized pro-resolving mediator and an acetylated derivative of COX2. 15 (R)-Lipoxin A4 is present in neurons. 15 (R)-Lipoxin A4 induces the SPM synthases ALOX12 and ALOX15, as well as the pro-resolving receptor ALX. 15 (R)-Lipoxin A4 inhibits protein kinases, including JNK1/2/3, Lyn, STAT-3 and STAT-6. 15 (R)-Lipoxin A4 enhances the release of pro-resolving mediators. 15 (R)-Lipoxin A4 alleviates the pro-inflammatory phenotype of tendon-derived stromal cells. 15 (R)-Lipoxin A4 promotes the resolution of neuroinflammation. 15 (R)-Lipoxin A4 is applicable to research related to achilles tendinitis, achilles tendon rupture and Alzheimer’s disease .

HY-100450

BML-111 1 Publications Verification	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Inflammation/Immunology Cancer
BML-111, a lipoxin A₄ analog, is a lipoxin A₄ receptor agonist. BML-111 represses the activity of angiotensin converting enzyme (ACE) and increases the activity of angiotensinconverting enzyme 2 (ACE2). BML-111 has antiangiogenic, antitumor and anti-inflammatory properties .

HY-N8440S1

Gibberellin A4-d2	Isotope-Labeled Compounds	Infection
Gibberellin A4-d2 is the deuterium labeled Gibberellin A4 (HY-N8440) .

HY-103226

SC-57461A 2 Publications Verification	Aminopeptidase	Inflammation/Immunology
SC-57461A is a potent, orally active, nonpeptide, and selective inhibitor of Leukotriene A4 (LTA4) hydrolase with IC₅₀s of 2.5 nM, 3 nM, and 23 nM for recombinant human, mouse, and rat LTA4 hydrolase, respectively .

HY-139351

Gibberellins A4/A7 GA4+7	Environmental Pollutants Endogenous Metabolite	Others
Gibberellins A4/A7 induces stimulation of tracheid production in the terminal shoot of intact plants is mediated through an increase in the IAA level in the cambial region .

HY-P990011

Sabirnetug ACU-193	Amyloid-β	Neurological Disease
Sabirnetug is a humanized IgG2κ antibody targeting the Amyloid-β A4 precursor protein.

HY-U00452

PL553	Fluorescent Dye	Inflammation/Immunology
PL553 is a specific and high-affinity fluorigenic substrate of Leukotriene A4 hydrolase, with a λ_max of 210 nm and λ_em of 410 nm.

HY-10825

DG051 1 Publications Verification	Aminopeptidase	Metabolic Disease
DG051 is a potent leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis in the enzyme assay with an IC₅₀=47 nM.

HY-B0134AS

Bestatin-d7 hydrochloride Ubenimex-d7 hydrochloride	Isotope-Labeled Compounds Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin-d₇ (hydrochloride) is deuterium labeled Bestatin (hydrochloride). Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

HY-126906R

Milbemycin A4 (Standard)	Reference Standards Antibiotic P-glycoprotein	Cancer
Milbemycin A4 (Standard) is the analytical standard of Milbemycin A4. This product is intended for research and analytical applications. Milbemycin A4 inhibits P-glycoprotein activity, and reverses multidrug resistance of tumor cells. Milbemycins are a family of macrolide antibiotics with insecticidal and acaricidal activity sup> .

HY-E70047

alpha-1,4-Galactosyltransferase (LgtC) A4GALT	Glycosyltransferase	Metabolic Disease
alpha-1,4-Galactosyltransferase (LgtC) (A4GALT) is a glycosphingolipid-specific glycosyltransferase. alpha-1,4-Galactosyltransferase (LgtC) transfers a galactose to the alpha-1,4 position of lactosylceramide to form globotriaosylceramide. alpha-1,4-Galactosyltransferase (LgtC) can be used for the synthesis of P1 blood group antigens .

HY-112621

Leukotriene A4 methyl ester LTA4 methyl ester	Biochemical Assay Reagents	Inflammation/Immunology
Leukotriene A4 methyl ester (LTA4 methyl ester) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively. LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells. Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis. LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.

HY-15855

Fosbretabulin tromethamine	Microtubule/Tubulin	Cancer
Fosbretabulin (tromethamine), also known as combretastatin A4 phosphate (CA4P), is a vascular disrupting agent evaluated for its efficacy against anaplastic thyroid carcinoma (ATC). It targets tumor neovasculature, causing acute and reversible reductions in tumor blood flow and central necrosis .

HY-157937

VISTA-IN-3	IFNAR	Cancer
VISTA-IN-3 (Compound A4) is a potent VISTA small molecule inhibitor with a K_D value of 0.49 μM. VISTA-IN-3 can induce the release of IFN-γ cytokines. VISTA-IN-3 synergistically enhances anti-cancer activity with PD-L1 antibody .

HY-W097753

4-MDM 4-Methoxydiphenylmethane	Aminopeptidase	Others
4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the Leukotriene A₄ Hydrolase (LTA₄H) aminopeptidase enzyme activity. 4-MDM reduces the neutrophil recruitment in the lung by enhancing the degradation of proline-glycine-proline by *LTA₄H, thereby reducing inflammation, and does not affect the epoxy-hydrolase activity of LTA₄H*. 4-MDM can be used for research on lung diseases .

HY-14815

Fosbretabulin Combretastatin A4 phosphate	Apoptosis Microtubule/Tubulin	Cancer
Fosbretabulin (Combretastatin A4 phosphate) is a vascular disruptor with antitumor activity against atypical thyroid carcinoma (ATC) cell lines and xenografts. Fosbretabulin inhibits tumor growth by inhibiting microtubule polymerization, inducing apoptosis, and suppressing angiogenesis in tumors .

HY-N2146R

Combretastatin A4 (Standard) CRC 87-09 (Standard)	Reference Standards Microtubule/Tubulin	Cancer
Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.

HY-146506

isoCA-4	Microtubule/Tubulin	Cancer
isoCA-4, a Combretastatin A4 derivative, is a tubulin polymerization inhibitor. isoCA-4 has anti-proliferative activities .

HY-163336

14,15-Leukotriene A4 methyl ester 14,15-LTA4 methyl ester	Drug Derivative	Inflammation/Immunology
14,15-Leukotriene A4 methyl ester (14,15-LTA4 methyl ester) is the methyl esterified form of Leukotriene A4, which can be used for the study of biological effects of leukotrienes .

HY-N4146R

Proanthocyanidin A4 (Standard)	Reference Standards Others	Inflammation/Immunology
Proanthocyanidin A4 (Standard) is the analytical standard of Proanthocyanidin A4. This product is intended for research and analytical applications. Proanthocyanidin A4 is a polyphenol found in a variety of plants. Proanthocyanidin A4 possesses anti-inflammatory effects .

HY-138074

Milbemycin A4 oxime 5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime	Parasite	Infection
Milbemycin A4 oxime (5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime) is a derivative of Milbemycin A4 (HY-126906) and a component of Milbemycin oxime (HY-B0778), both of which have insecticidal and nematicidal activities. Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae in naturally infected dogs with D. immitis and inhibits the growth of clinical isolates of Candida glabrata (MIC₈₀=16-32 μg/mL). Milbemycin A4 oxime (2.5 μg/mL) blocks the efflux of Fluconazole (HY-B0101) from clinical isolates of Candida glabrata. Milbemycin A4 oxime enhances doxorubicin-induced cell growth inhibition and increases the intracellular accumulation of doxorubicin and P-glycoprotein substrate Rhodamine 123 (HY-D0816) in doxorubicin-resistant but not sensitive MCF-7 breast cancer cells in a concentration-dependent manner.

HY-N14467

Pneumocandin A4	Antibiotic Bacterial	Infection
Pneumocandin A4 is a lipopeptide antibiotic. Pneumocandin A4 has a strong anti-Candida effect. Pneumocandin A4 has the effect of inhibiting the synthesis of 1,3 early-glucan in vitro, with an IC₅₀ of 0.07-0.5 μg/mL .

HY-158532

A4 glycan A4 N-linked oligosaccharide	Biochemical Assay Reagents	Others
A4 glycan (A4 N-linked oligosaccharide) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-N14449

Salfredin A4	Aldose Reductase	Metabolic Disease
Salfredin A4 is an aldose reductase inhibitor .

HY-N8333

Lepimectin A4	Insecticide	Others
Lepimectin A4, a macrocyclic lactone, is a component of the insecticide Lepimectin .

HY-138023

Leucomycin A4	Antibiotic Bacterial	Infection
Leucomycin A4 is a macrolide antibiotic that can be extracted from S. kitasatoensis. Leucomycin A4 inhibits a variety of bacteria, including S. aureus, B. subtilis, C. diphtheriae, N. gonorrhoeae, and H. influenzae (MICs = 0.15, 1.25, 0.15, 0.6, and 0.15 µg/ml, respectively) .

HY-N14865

Midecamycin A4	Bacterial	Infection
Midecamycin A4 is a macrolide compound with strong anti-Gram-positive bacteria and weak anti-Gram-negative bacteria, mycobacteria and fungi activity .

HY-158541

A4 glycan, 2-AB labelled A4 N-linked oligosaccharide, 2-AB labelled	Fluorescent Dye Biochemical Assay Reagents	Others
A4 glycan, 2-AB labelled (A4 N-linked oligosaccharide, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158540

A4 glycan, 2-AA labelled A4 N-linked oligosaccharide, 2-AA labelled	Biochemical Assay Reagents	Others
A4 glycan, 2-AA labelled (A4 N-linked oligosaccharide, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-126722

Lipoxin A4 methyl ester	Biochemical Assay Reagents	Inflammation/Immunology
Lipoxin A4 methyl ester is a stable synthetic analog of lipoxin with anti-inflammatory properties that can be extracted from arachidonic acid .

HY-113509A

6-epi-Lipoxin A4 6-epi-LXA4	Drug Derivative	Others
6-epi-Lipoxin A4 is an active compound.

HY-113509S

Lipoxin A4-d5 LXA4-d₅	Interleukin Related Endogenous Metabolite	Inflammation/Immunology
Lipoxin A4-d₅ is the deuterium labeled Lipoxin A4. Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties . Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways . Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC₅₀ value of 25.74 nM .

HY-126874

Tyropeptin A-4 TP-101	Proteasome	Others
Tyropeptin A-4 (TP-101) is a potent proteasome inhibitor with the ability to inhibit mammalian 20S proteasome activity. Tyropeptin A-4 exerts its inhibitory effect by binding to the site responsible for trypsin-like activity. Tyropeptin A-4 derivative TP-104 has a 20-fold increase in inhibitory activity over Tyropeptin A. TP-110 specifically inhibits trypsin-like activity without affecting PGPH and trypsin-like activity .

HY-139623

A4B17	Androgen Receptor	Cancer
A4B17 is an androgen receptor N-terminal inhibitor for researching androgen-responsive prostate cancer.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0134

Bestatin Maximum Cited Publications 11 Publications Verification Ubenimex	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Aminopeptidase Bacterial Antibiotic
Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects .

HY-N2146

Combretastatin A4 4 Publications Verification CRC 87-09	Structural Classification Monophenols other families Stilbenes Classification of Application Fields Phenols Plants Disease Research Fields Source Classification Cancer	Microtubule/Tubulin
Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with K_d of 0.4 μM.

HY-N8440

Gibberellin A4	Infection Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Gibberellins Phytohormone Endogenous metabolite Disease Research Fields Source Classification Agricultural Research	NF-κB
Gibberellin A4 is a type of bioactive gibberellin. Gibberellin A4 promotes flowering in apple trees. Gibberellin A4 also exhibits anti-NF-κB and antioxidant activities. Gibberellin A4 can be used in the research of periodontal diseases .

HY-B0134A

Bestatin hydrochloride Maximum Cited Publications 11 Publications Verification Ubenimex hydrochloride	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Antibiotic Bacterial Aminopeptidase
Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

HY-17449

Fosbretabulin disodium CA 4DP; CA 4P; Combretastatin A4 disodium phosphate	other families Stilbenes Classification of Application Fields Plants Disease Research Fields Cancer Source Classification	Microtubule/Tubulin Apoptosis
Fosbretabulin disodium (CA 4DP) is a tubulin destabilizing agent. Fosbretabulin disodium is the Combretastatin A4 proagent that selectively targets endothelial cells, induces regression of nascent tumour neovessels, reduces tumour blood flow and causes central tumour necrosis .

HY-113509

Lipoxin A4 1 Publications Verification LXA4	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Interleukin Related Endogenous Metabolite
Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties . Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways . Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC₅₀ value of 25.74 nM .

HY-B0778

Milbemycin oxime 1 Publications Verification	Infection Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Antibiotic Parasite
Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .

HY-N4146

Proanthocyanidin A4	Classification of Application Fields Vitis vinifera cv. Zalema Plants Vitaceae Flavonoids Functional Molecules Research of Health Products Phenols Polyphenols Biflavones Inflammation/Immunology Disease Research Fields Source Classification	Others
Proanthocyanidin A4 is a polyphenol found in a variety of plants. Proanthocyanidin A4 possesses anti-inflammatory effects .

HY-113509B

15(R)-Lipoxin A4 15-epi-LXA4	Structural Classification Natural Products Source Classification	STAT COX Lipoxygenase JNK Endogenous Metabolite
15 (R)-Lipoxin A4 (15-epi-LXA4) is a specialized pro-resolving mediator and an acetylated derivative of COX2. 15 (R)-Lipoxin A4 is present in neurons. 15 (R)-Lipoxin A4 induces the SPM synthases ALOX12 and ALOX15, as well as the pro-resolving receptor ALX. 15 (R)-Lipoxin A4 inhibits protein kinases, including JNK1/2/3, Lyn, STAT-3 and STAT-6. 15 (R)-Lipoxin A4 enhances the release of pro-resolving mediators. 15 (R)-Lipoxin A4 alleviates the pro-inflammatory phenotype of tendon-derived stromal cells. 15 (R)-Lipoxin A4 promotes the resolution of neuroinflammation. 15 (R)-Lipoxin A4 is applicable to research related to achilles tendinitis, achilles tendon rupture and Alzheimer’s disease .

HY-N2146R

Combretastatin A4 (Standard) CRC 87-09 (Standard)	Structural Classification Monophenols other families Stilbenes Phenols Plants Source Classification	Reference Standards Microtubule/Tubulin
Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.

HY-N4146R

Proanthocyanidin A4 (Standard)	Structural Classification Flavonoids Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae Biflavones Source Classification	Reference Standards Others
Proanthocyanidin A4 (Standard) is the analytical standard of Proanthocyanidin A4. This product is intended for research and analytical applications. Proanthocyanidin A4 is a polyphenol found in a variety of plants. Proanthocyanidin A4 possesses anti-inflammatory effects .

HY-N14467

Pneumocandin A4	Monophenols Microorganisms Antibiotics Phenols Source Classification	Antibiotic Bacterial
Pneumocandin A4 is a lipopeptide antibiotic. Pneumocandin A4 has a strong anti-Candida effect. Pneumocandin A4 has the effect of inhibiting the synthesis of 1,3 early-glucan in vitro, with an IC₅₀ of 0.07-0.5 μg/mL .

HY-N14449

Salfredin A4	Natural Products Microorganisms Source Classification	Aldose Reductase
Salfredin A4 is an aldose reductase inhibitor .

HY-138023

Leucomycin A4	Microorganisms Antibiotics Source Classification	Antibiotic Bacterial
Leucomycin A4 is a macrolide antibiotic that can be extracted from S. kitasatoensis. Leucomycin A4 inhibits a variety of bacteria, including S. aureus, B. subtilis, C. diphtheriae, N. gonorrhoeae, and H. influenzae (MICs = 0.15, 1.25, 0.15, 0.6, and 0.15 µg/ml, respectively) .

HY-N14865

Midecamycin A4	Microorganisms Macrolide Antibiotics Antibiotics Source Classification	Bacterial
Midecamycin A4 is a macrolide compound with strong anti-Gram-positive bacteria and weak anti-Gram-negative bacteria, mycobacteria and fungi activity .

HY-125770

5(S)-HPETE 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
5(S)-HPETE is a 5-lipoxygenase substrate and Arachidonic acid (HY-109590) metabolite. 5(S)-HPETE forms via 5-LOX-catalyzed hydroperoxidation of arachidonic acid. 5(S)-HPETE undergoes 5-LOX-catalyzed epoxidation (dehydration) to form leukotriene A4. 5(S)-HPETE can be used for the research of asthma, rheumatoid arthritis .

HY-B0134R

Bestatin (Standard) Ubenimex (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Reference Standards Aminopeptidase Bacterial Antibiotic
Bestatin (Standard) is the analytical standard of Bestatin. This product is intended for research and analytical applications. Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects .

HY-N9666

Chromomycin A4	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic Bacterial
Chromomycin A4, a major byproduct of Chromomycin A3 (HY-W040129)'s manufacture, is an antibiotic produced by Streptomyces griseus No. 7. Chromomycin A4 exhibits cancerostatic and antitumor activity. Chromomycin A4 shows strong growth inhibition against Gram-positive bacteria and and activity against tuberculous bacilli. Chromomycin A4 can be used for the research of bacterial infection .

HY-N13468

Sibiricose A4	Simple Phenylpropanols Polygalaceae Phenylpropanoids Plants Polygala tenuifolia Willd. Source Classification	Others
Sibiricose A4 is a natural product .

HY-N17607

Foliasalacin A4	Structural Classification Salacia chinensis L. Celastraceae Plants Steroids Source Classification	Drug Derivative
Foliasalacin A4 (Compound 4) is a dammarane-type triterpene isolated from the leaves of Salacia chinensis .

HY-N14177

Cyathin A4	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Cyathin A4 has weak activity against Gram-positive bacteria, negative bacteria, actinomycetes and dermatophytes, and has anti-ischemia effect (improving cerebral ischemia in rat model) .

HY-B0134B

Bestatin trifluoroacetate Ubenimex trifluoroacetate	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Aminopeptidase Bacterial Antibiotic
Bestatin trifluoroacetate is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

HY-B0134AR

Bestatin hydrochloride (Standard) Ubenimex hydrochloride (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Reference Standards Aminopeptidase Bacterial Antibiotic
Bestatin (hydrochloride) (Standard) is the analytical standard of Bestatin (hydrochloride). This product is intended for research and analytical applications. Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

HY-B0778R

Milbemycin oxime (Standard)	Structural Classification Natural Products Microorganisms Source Classification	Reference Standards Antibiotic Parasite
Milbemycin oxime (Standard) is the analytical standard of Milbemycin oxime. This product is intended for research and analytical applications. Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .

HY-N8426

4'-O-Methylnyasol Ellisinin A	Natural Products Liliaceae Anemarrhena asphodeloides Bunge Plants Source Classification	Histamine Receptor
4'-O-Methylnyasol is an inhibitor of β-hexosaminidase. 4'-O-Methylnyasol inhibits β-hexosaminidase release from rat basophilic leukemia-2H3 cells with an IC₅₀ of 52.67 μM .

HY-138146

4-Dehydrowithaferin A 4-oxo Withaferin A	Quinones Classification of Application Fields Benzene Quinones Withania somnifera Solanaceae Plants Disease Research Fields Source Classification Cancer	Drug Derivative
4-Dehydrowithaferin A is the analogue of withaferin A. Withaferin A is a withanolide isolated from Withania somnifera. 4-Dehydrowithaferin A has the potential for the research of multiple myeloma .

HY-N17494

Crispene E	Structural Classification Terpenoids Diterpenoids Plants Tinospora crispa (L.) Hook. f. et Thoms Menispermaceae Source Classification	STAT Bcl-2 Family CDK
Crispene E is a STAT3 inhibitor with an IC₅₀ of 10.27 μM against STAT3 dimerization. Crispene E exerts specific cytotoxicity against STAT3-dependent MDA-MB-231 breast cancer cells. Crispene E is applicable to research related to breast cancer .

Cat. No.	Product Name	Chemical Structure

HY-N8440S1

Gibberellin A4-d2
Gibberellin A4-d2 is the deuterium labeled Gibberellin A4 (HY-N8440) .

HY-B0134AS

Bestatin-d7 hydrochloride
Bestatin-d₇ (hydrochloride) is deuterium labeled Bestatin (hydrochloride). Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

HY-113509S

Lipoxin A4-d5

Lipoxin A4-d₅ is the deuterium labeled Lipoxin A4. Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties . Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways . Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC₅₀ value of 25.74 nM .

HY-137083S

Trifluoperazine N-glucuronide-d3
Trifluoperazine N-glucuronide-d₃ is deuterium labeled Trifluoperazine N-Glucuronide. Trifluoperazine N-Glucuronide (UGT1A4), as one of the human UGT1A isoforms, is expressed in the liver. Trifluoperazine N-Glucuronide catalyzes the imipramine and trifluoperazine Nglucuronide formation .

HY-B0134S1

Bestatin-d10
Bestatin-d₁₀ (Ubenimex-d₁₀) is deuterium labeled Bestatin. Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects .

HY-W068988S

3a,4,7,7a-Tetrahydro-1H-isoindole-1,3(2H)-dione-d6
3a,4,7,7a-Tetrahydro-1H-isoindole-1,3(2H)-dione-d₆ (1,2,3,6-Tetrahydrophthalimide-d₆) is the deuterium labeled 3a,4,7,7a-Tetrahydro-1H-isoindole-1,3(2H)-dione (HY-W068988).

HY-W015597S

rel-3a,4,7,7a-Tetrahydro-1H-isoindole-1,3(2H)-dione-d6
rel-3a,4,7,7a-Tetrahydro-1H-isoindole-1,3(2H)-dione-d₆ is the deuterium labeled rel-3a,4,7,7a-Tetrahydro-1H-isoindole-1,3(2H)-dione .

HY-W004291S

Methyl arachidate-d39
Methyl arachidate-d39 is the deuterated Methyl arachidate. Methyl arachidate, a natural compound, is a?leukotriene A4 hydrolase?(LTA4H)?inhibitor

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