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Results for "

ABPP

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

1

Recombinant Proteins

13

Antibodies

2

Click Chemistry

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1018A
    Phenelzine sulfate
    5+ Cited Publications

    		 Monoamine Oxidase GABA Receptor Histone Demethylase Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .
    Phenelzine sulfate
  • HY-112862
    Arg-AMS
    1 Publications Verification

    		 Aminoacyl-tRNA Synthetase Infection
    Arg-AMS (compound 24) is a potent nanomolar inhibitor of arginyl tRNA synthetase, which displays tightly bound inhibitory characteristics for the A-domains in non-ribosomal peptide synthetases (NRPS) enzymes .
    Arg-AMS
  • HY-RS00863
    APP Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    APP Human Pre-designed siRNA Set A contains three designed siRNAs for APP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    APP Human Pre-designed siRNA Set A
    APP Human Pre-designed siRNA Set A
  • HY-126943
    SAHA-BPyne

    		Fluorescent Dye Others
    SAHA-BPyne is an activity-based protein profiling (ABPP) probe for detecting HDAC activity, which covalently labels the proximal proteins through a photoactivation. SAHA-BPyne inhibits HDAC activity in HeLa nuclear lysate with an IC50 of less than 5 μM .
    SAHA-BPyne
  • HY-111199
    JP83

    		FAAH Neurological Disease
    JP83 is an irreversible fatty acyl amide hydrolase (FAAH) inhibitor with an IC50 of 1.6 nM in competitive activity-based protein profiling (ABPP) experiments .
    JP83
  • HY-125384
    ARN14686

    		Fluorescent Dye Inflammation/Immunology
    ARN14686 is an activity-based protein profiling (ABPP) probe. ARN14686 inhibits hNAAA with high potency (IC50=0.006 μM). ARN14686 interacts with NAAA via covalent binding to the N-terminal cysteine. ARN14686 binds only to the catalytically active form of NAAA, and may serve therefore as an efficient activity-based probe .
    ARN14686
  • HY-RS00864
    App Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    App Mouse Pre-designed siRNA Set A contains three designed siRNAs for App gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    App Mouse Pre-designed siRNA Set A
    App Mouse Pre-designed siRNA Set A
  • HY-147209
    DC-TEAD3in03

    		YAP Metabolic Disease
    DC-TEAD3in03 is a subtype-selective and covalent TEAD3 inhibitor with an IC50 of 0.16 μM. DC-TEAD3in03 exhibits the inhibitory activity on TEAD1/2/4 reduced by more than 100 times. DC-TEAD3in03 has the IC50 for TEAD3 of 1.15 μM in the GAL4-TEAD reporter gene experiment in cells, and it does not interfere with the β-catenin pathway. DC-TEAD3in03 reduces the growth rate of the zebrafish tail fin. DC-TEAD3in03 can be used to study the proportional growth of appendages in vertebrates .
    DC-TEAD3in03
  • HY-179635
    GSTO1-IN-6

    		Glutathione S-transferase Interleukin Related Inflammation/Immunology
    GSTO1-IN-6 is an allosteric and covalent GSTO1 inhibitor with an IC50 of 457 nM. GSTO1-IN-6 markedly reduces Lipopolysaccharides (LPS) (HY-D1056)-induced IL-1β (IC50 of 1.9 μM) and IL-18 (IC50 of 10. μM) secretion in human monocyte-derived macrophages. GSTO1-IN-6 covalently modifies GSTO1-Cys32, inducing conformational changes and protein destabilization. GSTO1-IN-6 can be used for the research of inflammatory diseases .
    GSTO1-IN-6

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