1. Search Result
Search Result
Results for "

Alisol A

" in MedChemExpress (MCE) Product Catalog:

19

Inhibitors & Agonists

19

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0853
    Alisol A
    5 Publications Verification

    AMPK Acetyl-CoA Carboxylase PPAR MMP Interleukin Related Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Alisol A is an orally active tetracyclic triterpenoid compound of the prototerpane type. Alisol A can be extracted from the rhizome of Alisma orientale. Alisol A activates AMPK/ACC/SREBP-1c, SIRT1, PPARα, inhibits MMP-2/-9, decreases inflammatory cytokine expression (IL-1β, IL-6, IL-8). Alisol A has anti-tumor activity against breast cancer and colorectal cancer. Alisol A has anti-obesity and anti-atherosclerotic activities. Alisol A can be used in the research of hepatitis B, breast cancer, colorectal cancer, atherosclerosis, and obesity .
    Alisol A
  • HY-N0805
    Alisol B 23-acetate
    3 Publications Verification

    23-Acetylalismol B; 23-O-AcetylAlisol B; Alisol B monoacetate

    Apoptosis Reactive Oxygen Species (ROS) CDK MMP PARP FXR Syk Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
    Alisol B 23-acetate is an orally active prototerpane-type triterpenoid. Alisol B 23-acetate can be isolated from Alisma orientalis. Alisol B 23-acetate induces Apoptosis, promotes ROS generation, downregulates CDK4/6, MMP-2/9, upregulates cleaved PARP, activates FXR and inhibits Syk. Alisol B 23-acetate has anti-inflammatory and hepatoprotective activities. Alisol B 23-acetate protects the kidney from ischemia-reperfusion injury. Alisol B 23-acetate has anticancer activity against ovarian cancer, colon cancer, lung cancer, and gastric cancer. Alisol B 23-acetate can be used in the study of atherosclerosis and allergic asthma .
    Alisol B 23-acetate
  • HY-N6570

    Others Others
    Alisol C is a triterpenoid that can be found in the tuber of Alisma orientale (Sam.) Juzep .
    Alisol C
  • HY-N0805A
    Alisol B
    1 Publications Verification

    Epoxide Hydrolase CaMK Autophagy Apoptosis Metabolic Disease Inflammation/Immunology Cancer
    Alisol B is a triterpene with diverse biological activities. Alisol B binds human soluble epoxide hydrolase (sEH) with a Ki of 5.97 μM and reduces sEH activity. Alisol B inhibits RANKL-induced JNK phosphorylation, NFATc1 and c-Fos expression, osteoclast formation, mature osteoclast pit-forming and actin ring activity, and SERCA pump activity. Alisol B induces calcium mobilization, CaMKK-AMPK-mTOR pathway activation, autophagic flux, autophagosome formation, G1 phase cell cycle arrest, endoplasmic reticulum stress, unfolded protein responses, and cancer cell apoptosis. Alisol B can be used for the research of hypercalcemia, osteoporosis, rheumatoid arthritis, periodontitis, acute kidney injury, and breast cancer .
    Alisol B
  • HY-N0853A
    Alisol A 24-acetate
    1 Publications Verification

    Alisol A 24-monoacetate; Alisol A monoacetate

    AMPK Carnitine Palmitoyltransferase (CPT) Acyltransferase Fatty Acid Synthase (FASN) Acetyl-CoA Carboxylase Bcl-2 Family PPAR Nuclear Factor of activated T Cells (NFAT) PI3K Akt PKA ERK Apoptosis Autophagy Cardiovascular Disease Infection Neurological Disease Metabolic Disease Endocrinology
    Alisol A 24-acetate (Alisol A monoacetate) is an orally active derivative of protostane-type tetracyclic triterpenoid. Alisol A 24-acetate upregulates the expression of adiponectin, AMPKα, CPT1, and ACOX1; downregulates the expression of SREBP-1c, ACC, FAS, Bcl-2, Bcl-xl, PPAR-γ, perilipin A, and NFATc1; inhibits the activity of PI3K/Akt/mTOR and HMGR; and activates the PKA and ERK signaling pathways. Alisol A 24-acetate regulates cell apoptosis (apoptosis), autophagy (Autophagy, hepatic lipid accumulation, inflammatory response, neuroprotection, MRSA membrane integrity, and osteoclast differentiation. Alisol A 24-acetate can be used in research related to non-alcoholic fatty liver disease, nephrotoxicity, obesity, global cerebral ischemia-reperfusion injury, bacterial infection, and osteoporosis .
    Alisol A 24-acetate
  • HY-N0856

    23-O-AcetylAlisol C; Alisol C monoacetate

    Others Cardiovascular Disease
    Alisol C 23-acetate, a natural product extracted from Alisma orinentale, can significantly and strongly inhibit DTH response after oral administration.
    Alisol C 23-acetate
  • HY-113046R
    5-Methyltetrahydrofolic acid (Standard)
    1 Publications Verification

    5-Methyl THF (Standard); 5-MTHF (Standard)

    Reference Standards Endogenous Metabolite Cardiovascular Disease Metabolic Disease
    Alisol C 23-acetate (Standard) is the analytical standard of Alisol C 23-acetate. This product is intended for research and analytical applications. Alisol C 23-acetate is a natural product extracted from Alisma orientale, which can significantly reduce delayed-type hypersensitivity reactions.
    5-Methyltetrahydrofolic acid (Standard)
  • HY-N0854
    Alisol F
    1 Publications Verification

    HBV ERK JNK p38 MAPK STAT NF-κB TNF Receptor Interleukin Related NO Synthase COX Metabolic Disease Cancer
    Alisol F is a protostane-type triterpenoid with anti-inflammatory and anti-hepatitis B virus activities. Alisol F inhibits LPS (HY-D1056)-induced phosphorylation of ERK, JNK, p38, STAT3 and NF-κB (p65), suppresses the production of NO, IL-6, TNF-α and IL-1β, and also downregulates the levels of iNOS and COX-2. Alisol F reduces the serum alanine aminotransferase and aspartate aminotransferase levels in mice with acute liver injury and ameliorates their liver pathological damage .
    Alisol F
  • HY-N0855

    Alisol-G; 25-AnhydroAlisol A

    Carboxylesterase (CES) Bacterial HBV Infection Cancer
    Alisol G (25-Anhydroalisol A) is a human carboxylesterase 2 (hCES2) inhibitor with an IC50 of 3.85 μM. Alisol G exhibits cytotoxic activity against human cancer cells, antibacterial activity against Gram-positive strains, and anti-hepatitis B virus activity. Alisol G can be used in research related to lung cancer, breast cancer, prostate cancer, bacterial infections, and HBV infections .
    Alisol G
  • HY-N0853AR

    Alisol A 24-monoacetate (Standard); Alisol A monoacetate (Standard)

    Reference Standards Others Others
    Alisol A 24-acetate (Standard) is the analytical standard of Alisol A 24-acetate. This product is intended for research and analytical applications.
    Alisol A 24-acetate (Standard)
  • HY-N0853R

    Reference Standards AMPK Acetyl-CoA Carboxylase PPAR MMP Interleukin Related Infection Cardiovascular Disease Metabolic Disease Cancer
    Alisol A (Standard) is the analytical standard of Alisol A (HY-N0853). This product is intended for research and analytical applications. Alisol A is an orally active tetracyclic triterpenoid compound of the prototerpane type. Alisol A can be extracted from the rhizome of Alisma orientale. Alisol A activates AMPK/ACC/SREBP-1c, SIRT1, PPARα, inhibits MMP-2/-9, decreases inflammatory cytokine expression (IL-1β, IL-6, IL-8). Alisol A has anti-tumor activity against breast cancer and colorectal cancer. Alisol A has anti-obesity and anti-atherosclerotic activities. Alisol A can be used in the research of hepatitis B, breast cancer, colorectal cancer, atherosclerosis, and obesity .
    Alisol A (Standard)
  • HY-129162

    Others Others
    Alisol A 23-acetate is a natural product that can be isolated from Rhizoma Alismatis .
    Alisol A 23-acetate
  • HY-N0805R

    23-Acetylalismol B (Standard); 23-O-AcetylAlisol B (Standard); Alisol B monoacetate (Standard)

    Reference Standards Apoptosis Reactive Oxygen Species (ROS) CDK MMP PARP FXR Syk Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
    Alisol B 23-acetate (Standard) is the analytical standard of Alisol B 23-acetate (HY-N0805). This product is intended for research and analytical applications. Alisol B 23-acetate is an orally active prototerpane-type triterpenoid. Alisol B 23-acetate can be isolated from Alisma orientalis. Alisol B 23-acetate induces Apoptosis, promotes ROS generation, downregulates CDK4/6, MMP-2/9, upregulates cleaved PARP, activates FXR and inhibits Syk. Alisol B 23-acetate has anti-inflammatory and hepatoprotective activities. Alisol B 23-acetate protects the kidney from ischemia-reperfusion injury. Alisol B 23-acetate has anticancer activity against ovarian cancer, colon cancer, lung cancer, and gastric cancer. Alisol B 23-acetate can be used in the study of atherosclerosis and allergic asthma .
    Alisol B 23-acetate (Standard)
  • HY-N0856R

    23-O-AcetylAlisol C (Standard); Alisol C monoacetate (Standard)

    Reference Standards Others Cardiovascular Disease
    Alisol C 23-acetate (Standard) is the analytical standard of Alisol C 23-acetate. This product is intended for research and analytical applications. Alisol C 23-acetate is a natural product extracted from Alisma orientale, which can significantly reduce delayed-type hypersensitivity reactions.
    Alisol C 23-acetate (Standard)
  • HY-N0805AR

    Reference Standards Epoxide Hydrolase CaMK Autophagy Apoptosis Metabolic Disease Inflammation/Immunology Cancer
    Alisol B (Standard) is the analytical standard of Alisol B (HY-N0805A). This product is intended for research and analytical applications. Alisol B is a triterpene with diverse biological activities. Alisol B binds human soluble epoxide hydrolase (sEH) with a Ki of 5.97 μM and reduces sEH activity. Alisol B inhibits RANKL-induced JNK phosphorylation, NFATc1 and c-Fos expression, osteoclast formation, mature osteoclast pit-forming and actin ring activity, and SERCA pump activity. Alisol B induces calcium mobilization, CaMKK-AMPK-mTOR pathway activation, autophagic flux, autophagosome formation, G1 phase cell cycle arrest, endoplasmic reticulum stress, unfolded protein responses, and cancer cell apoptosis. Alisol B can be used for the research of hypercalcemia, osteoporosis, rheumatoid arthritis, periodontitis, acute kidney injury, and breast cancer.
    Alisol B (Standard)
  • HY-107315

    HBV Apoptosis Infection Cancer
    Alisol F 24-acetate is a triterpene compound that can be isolated from the rhizomes of Alisma orientalis. Alisol F 24-acetate inhibits the secretion of HBV surface antigen HBsAg and HBeAg with IC50 values of 7.7 µM and 5.1 µM. Alisol F 24-acetate has proapoptotic activity and can be used for cancer research .
    Alisol F 24-acetate
  • HY-126365

    Apoptosis Caspase PI3K Akt Others
    Alisol B acetate is a Triterpenoids product that can be isolated from the tubers of Alisma plantago-aquatica Linn. .
    Alisol B acetate
  • HY-N8635

    Others Others
    Alisol E 23-acetate is a Triterpenoids product that can be isolated from the tubers of Alisma plantago-aquatica Linn. .
    Alisol E 23-acetate
  • HY-129161

    Others Others
    Alisol O is a Triterpenoids product that can be isolated from the tubers of Alisma plantago-aquatica Linn. .
    Alisol O

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

 

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

 

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: