Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
Apical Sodium-Dependent Bile Acid Transporter
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "Apical Sodium-Dependent Bile Acid Transporter" in MCE Product Catalog:
13
Research Areas:
Linerixibat (GSK2330672) is a highly potent, nonabsorbable and orally active apical sodium-dependent bile acid transporter (ASBT) inhibitor with an IC50 of 42 nM human ASBT. Linerixibat can be used as lipid-lowering agent. Linerixibat has the potential for type 2 diabetes and Primary Biliary Cholangitis treatment .
9
9 Cited Publications
Cat. No.: HY-104081
CAS No.: 11041-12-6
Synonyms: Cholestyramine resin; Colestyramine
Research Areas:
Cholestyramine (Cholestyramine resin) is an orally active bile acid sequestrant. Cholestyramine upregulates the expression of intestinal Apical sodium-dependent bile acid transporter and hepatic Cholesterol 7α-hydroxylase. Cholestyramine induces the expression of intestinal and hepatic cholesterol synthesis genes as well as hepatic lipogenesis genes, and promotes bile acid- and neutral sterol-mediated reverse cholesterol transport. Cholestyramine reduces intestinal cholesterol absorption and induces cholesterol efflux. Cholestyramine is applicable to research related to coronary artery disease, atherosclerotic cardiovascular disease and atherosclerosis .
4
Research Areas:
Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .
Cat. No.: HY-101190
CAS No.: 1025216-57-2
Synonyms: SHP626; LUM002
Research Areas:
Volixibat (SHP626) is a highly selective, minimally absorbed, and competitive apical sodium-dependent bile acid transporter (ASBT) inhibitor. Volixibat has potential for treatment for non-alcoholic steatohepatitis (NASH) .
Cat. No.: HY-148795
CAS No.: 2460667-52-9
Research Areas:
Ritivixibat is an apical sodium-dependent bile acid transporter (ASBT/IBAT) inhibitor. Ritivixibat blocks ASBT/IBAT function, thereby reducing bile acid reabsorption, regulating bile acid homeostasis and alleviating liver injury. Ritivixibat protects cholangiocytes from damage caused by cytotoxic bile acids. Ritivixibat is applicable to research related to primary sclerosing cholangitis .
Cat. No.: HY-109120R
CAS No.: 501692-44-0
Synonyms: A4250 (Standard)
Research Areas:
Odevixibat (Standard) is the analytical standard of Odevixibat. This product is intended for research and analytical applications. Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .
Cat. No.: HY-109120S
Synonyms: A4250-d5
Cat. No.: HY-109120S1
Synonyms: A4250-13C6
Cat. No.: HY-130301
CAS No.: 142974-51-4
Synonyms: S 0960
Research Areas:
Gallensre (S 0960) is an apical sodium-dependent bile acid transporter inhibitor (IC50 = 5.8 μmol/L). Gallensre inhibits bile salt reabsorption in a rat model. Gallensre can be used to study metabolic diseases such as bile acid cycling .
Cat. No.: HY-101190A
Synonyms: (3R,4S,5S)-SHP626; (3R,4S,5S)-LUM002
Target:
Research Areas:
(3R,4S,5S)-Volixibat ((3R,4S,5S)-SHP626) is an isomer of Volixibat (HY-101190). Volixibat is a highly selective, minimally absorbed, and competitive apical sodium-dependent bile acid transporter (ASBT) inhibitor. (3R,4S,5S)-Volixibat may be used in research on non-alcoholic steatohepatitis (NASH) .
Cat. No.: HY-P705614
Purity: Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: SLC10A2; Na+/Taurocholate Cotransporting Polypeptide 2; Prev. ASBT; Ileal Sodium/Bile Acid CoTransporter; Prev. ISBT; Ileal Bile Acid Transporter; NTCP2; Solute Carrier Family 10 (Sodium/Bile Acid CoTransporter Family), Member 2; IBAT; Ileal Apical Sodium
Species:
Human
Source:
HEK293
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
